Photo of Louis Jeffrey Picker, M.D.

Louis Jeffrey Picker M.D.

    • Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Louis Picker graduated from UCLA with a B.S. in bacteriology in 1978 and took his M.D. degree at the University of California at San Francisco in 1982. After residency training in pathology at Beth Israel Hospital, Boston, and postdoctoral training in immunology at Stanford University Medical Center, he was appointed assistant professor and then associate professor of pathology at the University of Texas Southwestern Medical Center at Dallas. In 1999 he came to OHSU and ONPRC as professor of pathology/molecular microbiology and immunology in the OHSU School of Medicine and head of the Division of Pathobiology and Immunology.

Areas of interest

  • Human and primate T cell biology
  • Immunologic Memory
  • Vaccine Development

Education

  • B.S., UCLA, Los Angeles California United States 1978
  • M.D., UCSF, San Francisco California United States 1982

Publications

Selected publications

  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB,Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A, Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ,Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi:10.1371/journal.ppat.1006014.[PMID: 27829026]

  • Ranasinghe S, Lamothe PA, Soghoian DZ, Kazer SW, Cole MB,Shalek AK, Yosef N, Jones RB, Donaghey F, Nwonu C, Jani P, Clayton GM, CrawfordF, White J, Montoya A, Power K, Allen TM, Streeck H, Kaufmann DE, Picker LJ,Kappler JW, Walker BD; Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit ClonalExpansion. Immunity.2016 Oct 18;45(4):917-930. doi:10.1016/j.immuni.2016.09.015. [PMID: 27760342]

  • Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS,Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G,Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, PickerLJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB; MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates. Mucosal Immunol. 2016 Oct 19.doi: 10.1038/mi.2016.91. [PMID: 2775902]

  • Theiler J, Yoon H, Yusim K, Picker LJ, Fruh K, Korber B. Epigraph:A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and a Pan-Filo virus Vaccine. Sci Rep. 2016 Oct 5;6:33987. doi: 10.1038/srep33987.[PMID: 27703185]

  • Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S,Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM,Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K. Natural KillerCell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. PLoS Pathog.2016 Aug 31;12(8):e1005868. doi: 10.1371/journal.ppat.1005868.[PMID: 27580123]

Publications

  • "Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding." Nature Communications  In: , Vol. 9, No. 1, 3137, 01.12.2018.
  • "Corrigendum to ‘Unusual antigen presentation offers new insight into HIV vaccine design’ [Curr Opin Immunol 46 (2017) 75–81] (Current Opinion in Immunology (2017) 46 (75–81), (S0952791516301583) (10.1016/j.coi.2017.04.009))." Current opinion in immunology  In: , Vol. 53, 01.08.2018.
  • "Potent immune modulation by medi6383, an engineered human ox40 ligand igg4p fc fusion protein." Molecular Cancer Therapeutics  In: , Vol. 17, No. 5, 01.05.2018, p. 1024-1038.
  • "Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine." Nature Medicine  In: , Vol. 24, No. 2, 01.02.2018, p. 130-143.
  • "The Role of MHC-E in T Cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques." Journal of Immunology  In: , Vol. 200, No. 1, 01.01.2018, p. 49-60.
  • "Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice." Scientific Reports  In: , Vol. 7, No. 1, 937, 01.12.2017.
  • "CD8+ T cell programming by cytomegalovirus vectors : applications in prophylactic and therapeutic vaccination." Current Opinion in Immunology  In: , Vol. 47, 01.08.2017, p. 52-56.
  • "Unusual antigen presentation offers new insight into HIV vaccine design." Current Opinion in Immunology  In: , Vol. 46, 01.06.2017, p. 75-81.
  • "MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates." Mucosal Immunology  In: , Vol. 10, No. 3, 01.05.2017, p. 802-813.
  • "Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques." PLoS Pathogens  In: , Vol. 12, No. 11, e1006014, 01.11.2016.
  • "Antiviral CD8 T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion." Immunity  In: , Vol. 45, No. 4, 18.10.2016, p. 917-930.
  • "Epigraph : A vaccine design tool applied to an HIV therapeutic vaccine and a pan-filovirus vaccine." Scientific Reports  In: , Vol. 6, 33987, 05.10.2016.
  • "Effect of anti-IL-15 administration on T Cell and NK cell homeostasis in rhesus macaques." Journal of Immunology  In: , Vol. 197, No. 4, 15.08.2016, p. 1183-1198.
  • "Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus." PLoS Pathogens  In: , Vol. 12, No. 8, e1005868, 01.08.2016.
  • "In situ staining and laser capture microdissection of lymph node residing SIV Gag-specific CD8 T cells - A tool to interrogate a functional immune response ex vivo." PLoS One  In: , Vol. 11, No. 3, e0149907, 01.03.2016.
  • "Broadly targeted CD8 T cell responses restricted by major histocompatibility complex E." Science  In: , Vol. 351, No. 6274, 12.02.2016, p. 714-720.
  • "A new perspective of the structural complexity of HCMV-specific T-cell responses." Mechanisms of Ageing and Development  In: , 06.11.2015.
  • "Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques." Journal of Immunology  In: , Vol. 195, No. 9, 01.11.2015, p. 4292-4305.
  • "HIV : Seeking ultimate victory." Nature  In: , Vol. 517, No. 7534, 15.01.2015, p. 281-282.
  • "B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers." Nature Medicine  In: , Vol. 21, No. 2, 2015, p. 132-139.
  • "Vaccine-induced linear epitope-specific antibodies to simian immunodeficiency virus SIVmac239 envelope are distinct from those induced to the human immunodeficiency virus type 1 envelope in nonhuman primates." Journal of Virology  In: , Vol. 89, No. 16, 2015, p. 8643-8650.
  • "Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance." Journal of Virology  In: , Vol. 89, No. 2, 2015, p. 1195-1204.
  • "Erratum : Immune clearance of highly pathogenic SIV infection (Nature (2013) 502 (100-104) DOI:10.1038/nature12519))." Nature  In: , Vol. 514, No. 7524, 30.10.2014, p. 654.
  • "Heterogeneity of CD4+ and CD8+ T-cell responses to cytomegalovirus in HIV-infected and HIV-uninfected men who have sex with men." Journal of Infectious Diseases  In: , Vol. 210, No. 3, 01.08.2014, p. 400-404.
  • "Novel vaccine vectors for HIV.1." Nature Reviews Microbiology  In: , Vol. 12, No. 11, 01.01.2014, p. 765-771.
  • "Cytomegalovirus pp65 limits dissemination but is dispensable for persistence." Journal of Clinical Investigation  In: , Vol. 124, No. 5, 2014, p. 1928-1944.
  • "Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events." Journal of Virology  In: , Vol. 88, No. 14, 2014, p. 8077-8090.
  • "Are effector memory T cells the key to an effective HIV/AIDS vaccine?" EMBO Reports  In: , Vol. 15, No. 8, 2014, p. 820-821.
  • "Development of replication-competent viral vectors for HIV vaccine delivery." Current Opinion in HIV and AIDS  In: , Vol. 8, No. 5, 09.2013, p. 402-411.
  • "CD4+ T-Cell Depletion In Hiv Infection : Mechanisms Of Immunological Failure." Immunological Reviews  In: , Vol. 254, No. 1, 07.2013, p. 54-64.

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