Photo of Lisa J Wood, Ph.D., R.N.

Lisa J Wood Ph.D., R.N.

  • (503) 494-3859

    Portland Campus

    • Associate Professor School of Nursing

The long-range goal of our research is to effectively treat and manage the most common symptom experienced by cancer patients undergoing chemotherapy, radiation therapy or both; fatigue. To date the molecular mechanisms underlying the initiation and perpetuation of CTRF are not well established, and, the precise role of inflammatory cytokines, if any, in CTRF remains unclear. Our research program utilizes a pre-clinical and clinical approach to examine the relationship between cancer treatment, inflammatory cytokines and CTRF. This “bench to bedside” approach to understanding the cause of CTRF arises from a unique interdisciplinary collaboration among molecular, behavioral, and clinical investigators all working at various points within the spectrum of cancer research at our institution and hence, represents a major innovation in cancer symptom research.This research is funded by the following grants:

(Wood/ Hill, MPI) 7/1/11-6/30/13
Department of Defense Breast Cancer Research Program, Collaborative Idea Award
Cytokine response to subclinical cytomegalovirus reactivation as a cause of severe fatigue in women undergoing chemotherapy for breast cancer.

(Wood, PI) 9/28/10-6/30/15
5R01NR012479-02, The National Institute for Nursing Research, Mechanisms of Cancer Treatment Related Symptoms.

(Winters-Stone/Wood, MPI) 2/1/12-8/31/13
1R21CA164661-01, National Cancer Institute
Influence of physical exercise on inflammatory biomarkers and adiposity in cancer survivors.


  • Ph.D., University of Glasgow, Glasgow United Kingdom 1995
  • B.S.N., Johns Hopkins University School of Nursing, Baltimore Maryland United States 2000


  • "Effects of Fluoxetine on Poststroke Dysphagia : A Clinical Retrospective Study." Journal of Stroke and Cerebrovascular Diseases  In: , Vol. 27, No. 11, 01.11.2018, p. 3320-3327.
  • "Impaired cognitive performance in endothelial nitric oxide synthase knockout mice after ischemic stroke." American Journal of Physical Medicine and Rehabilitation  In: , Vol. 97, No. 7, 01.07.2018, p. 492-499.
  • "The effects of resistance exercise on biomarkers of breast cancer prognosis : A pooled analysis of three randomized trials." Cancer Epidemiology Biomarkers and Prevention  In: , Vol. 27, No. 2, 01.02.2018, p. 146-153.
  • "The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke." Translational Stroke Research  In: , 01.01.2018.
  • "Development and evaluation of a six-day training program in supportive oncology research." Palliative and Supportive Care  In: , 28.12.2017, p. 1-6.
  • "Dexamethasone exacerbates cytotoxic chemotherapy induced lethargy and weight loss in female tumor free mice." Cancer Biology and Therapy  In: , 08.12.2017, p. 1-10.
  • "Lysosomal Proteolysis Is Associated with Exercise-Induced Improvement of Mitochondrial Quality Control in Aged Hippocampus." Journals of Gerontology - Series A Biological Sciences and Medical Sciences  In: , Vol. 72, No. 10, 01.10.2017, p. 1342-1351.
  • "Auricular point acupressure to manage aromatase inhibitor-induced arthralgia in postmenopausal breast cancer survivors : A pilot study." Oncology Nursing Forum  In: , Vol. 44, No. 4, 01.07.2017, p. 476-487.
  • "Lung inflammation caused by inhaled toxicants : A review." International Journal of COPD  In: , Vol. 11, No. 1, 23.06.2016, p. 1391-1401.
  • "Localized External Beam Radiation Therapy (EBRT) to the Pelvis Induces Systemic IL-1Beta and TNF-Alpha Production : Role of the TNF-Alpha Signaling in EBRT-Induced Fatigue." Radiation Research  In: , Vol. 185, No. 1, 01.01.2016, p. 4-12.
  • "Relationship between fatigue, sleep quality and inflammatory cytokines during external beam radiation therapy for prostate cancer : A prospective study." Radiotherapy and Oncology  In: , Vol. 118, No. 1, 01.01.2016, p. 105-111.
  • "Induction of IL-6 by Cytotoxic Chemotherapy Is Associated With Loss of Lean Body and Fat Mass in Tumor-free Female Mice." Biological Research for Nursing  In: , Vol. 17, No. 5, 08.10.2015, p. 549-557.
  • "Increased Th17/Treg Ratio in Poststroke Fatigue." Mediators of Inflammation  In: , Vol. 2015, 931398, 2015.
  • "Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia." Journal of Neuroimmunology  In: , Vol. 277, No. 1-2, 15.12.2014, p. 160-167.
  • "Proinflammatory cytokines and DHEA-S in women with fibromyalgia : Impact of psychological distress and menopausal status." Journal of Pain Research  In: , Vol. 7, 04.12.2014, p. 707-716.
  • "Preliminary differences in peripheral immune markers and brain metabolites between fatigued and non-fatigued breast cancer survivors : a pilot study." Brain Imaging and Behavior  In: , Vol. 8, No. 4, 23.11.2014, p. 506-516.
  • "Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs : Synergistic effects of doxorubicin and vincristine." Cancer Biology and Therapy  In: , Vol. 15, No. 10, 01.10.2014, p. 1395-1403.
  • "A role for orexin in cytotoxic chemotherapy-induced fatigue." Brain, Behavior, and Immunity  In: , Vol. 37, 03.2014, p. 84-94.
  • "The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS) : A study using cytokine receptor-deficient mice." Brain, Behavior, and Immunity  In: , Vol. 38, 2014, p. 66-76.
  • "Inflammation and neural signaling : Etiologic mechanisms of the cancer treatment-related symptom cluster." Current Opinion in Supportive and Palliative Care  In: , Vol. 7, No. 1, 03.2013, p. 54-59.
  • "Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of Doxorubicin." Cancer Biology and Therapy  In: , Vol. 14, No. 1, 01.2013, p. 56-63.
  • "Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome." Cancer Biology and Therapy  In: , Vol. 11, No. 12, 15.06.2011, p. 1008-1016.
  • "An epidermotypic model of interface dermatitis reveals individual functions of fas ligand and gamma interferon in hypergranulosis, cytoid body formation, and gene expression." American Journal of Dermatopathology  In: , Vol. 33, No. 3, 05.2011, p. 244-250.
  • "A specific need for CRKL in p210BCR-ABL - Induced transformation of mouse hematopoietic progenitors." Cancer Research  In: , Vol. 70, No. 18, 15.09.2010, p. 7325-7335.
  • "CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms." Blood  In: , Vol. 115, No. 25, 24.06.2010, p. 5232-5240.
  • "Atypical depression is more common than melancholic in fibromyalgia : An observational cohort study." BMC Musculoskeletal Disorders  In: , Vol. 11, 120, 2010.
  • "Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer." Molecular Cancer Research  In: , Vol. 7, No. 11, 11.2009, p. 1803-1812.
  • "Does muscle-derived interleukin-6 mediate some of the beneficial effects of exercise on cancer treatment-related fatigue." Oncology Nursing Forum  In: , Vol. 36, No. 5, 09.2009, p. 519-524.
  • "Inhibition of p38 MAPK suppresses inflammatory cytokine induction by etoposide, 5-fluorouracil, and doxorubicin without affecting tumoricidal activity." PLoS One  In: , Vol. 3, No. 6, e2355, 04.06.2008.
  • "HMGA2 participates in transformation in human lung cancer." Molecular Cancer Research  In: , Vol. 6, No. 5, 01.05.2008, p. 743-750.

Additional information

Edit profile