Photo of Justin S. Cetas, M.D., Ph.D.

Justin S. Cetas M.D., Ph.D.

  • (503) 494-4314
    • Associate Professor of Neurological Surgery, Division of Skull Base and Cerebrovascular School of Medicine
    • Residency Program Director Neurological Surgery School of Medicine

The major focus of Dr. Cetas's laboratory is to understand the effects of subarachnoid hemorrhage on the brainstem and central nervous system and their subsequent role in determining long-term outcomes.

Delayed vasospasm is a common and devastating consequence of subarachnoid hemorrhage (SAH) that is poorly understood with few effective treatments. The aim of Dr. Cetas's laboratory research is to identify a novel biomarker for predicting a patient's risk for developing delayed vasospasm and subsequent neurological deficits, as well as a new potential therapeutic target for the medical prevention of delayed vasospasm. Specifically, preliminary data both in animal models and patients of SAH suggest that a group of potent vasodilator metabolites of arachidonic acid (called epoxyeicosatrienoic acids or simply EETs) are linked to the development of vasospasm and may predict its development after SAH. The reasearchers propose to test the hypothesis that EETs levels after SAH correlate with the development of delayed vasospasm and that polymorphisms in the gene EPHX2 (which regulates the metabolism of EETs) correlate with an individual’s EETs response. They anticipate that individuals whose EETs levels are elevated after SAH will not go on to develop vasospasm. Furthermore, they predict that those individuals who do not elevate their EETs levels after SAH will have a higher frequency of polymorphisms in the EPHX2 gene.

 

 

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Education

  • B.A., St. John’s College, Santa Fe New Mexico 1993
  • Ph.D., University of Arizona, Tuscon Arizona 2000
  • M.D., University of Arizona, Tucson Arizona 2002
  • Residency:

    • Neurological surgery, Oregon Health & Science University, 2009
  • Fellowship:

    • Skull base surgery, Oregon Health & Science University, 2010
  • Certifications:

    • American Board of Neurological Surgery: certified

Memberships and associations

  • American Academy of Neurological Surgeons

Publications

  • "Destructive procedures for control of cancer pain" Journal of Neurosurgery January 2011
  • "Protective Role of P450 Epoxyeicosanoids in Subarachnoid Hemorrhage" Neurocritical Care  2015
  • "Purinergic actions on neurons that modulate nociception in the rostral ventromedial medulla" Neuroscience June 8 2007
  • "Thalamocortical afferents of Lorente de No" Brain Research May 29 1999
  • "Destructive procedures for the treatment of nonmalignant pain" Journal of Neurosurgery September 2008
  • "Brainstem Opioidergic System Is Involved in Early Response to Experimental SAH" Translational Stroke Research  2015
  • "Intracisternal Administration of Tissue Plasminogen Activator Improves Cerebrospinal Fluid Flow and Cortical Perfusion After Subarachnoid Hemorrhage in Mice" Translational Stroke Research  2014
  • "Genetic variation in soluble epoxide hydrolase" Journal of Neurosurgery December 1 2014
  • "Optochiasmatic cavernous hemangioma" British Journal of Neurosurgery June 2010
  • "Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients" Journal of Neurophysiology February 2010
  • "Functional subregions in primary auditory cortex defined by thalamocortical terminal arbors" Journal of Neuroscience January 1 2003
  • "Newborn with sebaceous nevus of Jadassohn presenting as exophytic scalp lesion" Pediatric Neurosurgery January 2008
  • "Response" Journal of Neurosurgery September 2008
  • "Purinergic receptor immunoreactivity in the rostral ventromedial medulla" Neuroscience January 23 2009
  • "Bilateral deep brain stimulation targeting ventralis intermedius nucleus to treat a professional musician's task-specific tremor" Movement Disorders November 2013
  • "Frequency organization and cellular lamination in the medial geniculate body of the rabbit" Hearing Research  2001
  • "Levodopa-responsive parkinsonism after aneurysmal subarachnoid hemorrhage" Neurocritical Care October 2010
  • "Delayed intracranial hypertension after cranial vault remodeling for nonsyndromic single-suture synostosis" Journal of neurosurgery. Pediatrics June 2013
  • "Response" Journal of Neurosurgery January 2011
  • "Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation after Subarachnoid Hemorrhage" Stroke July 4 2015
  • "Steroid psychosis" Journal of Neuro-Oncology September 2012
  • "A possible neural basis for stress-induced hyperalgesia" Pain April 2009
  • "Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage" Neuroscience October 6 2009
  • "Dendritic orientation and laminar architecture in the rabbit auditory thalamus" Journal of Comparative Neurology April 7 2003
  • "Preoperative identification of the facial nerve in patients with large cerebellopontine angle tumors using high-density diffusion tensor imaging" Journal of Neurosurgery April 2012
  • "The deleterious effects of methamphetamine use on initial presentation and clinical outcomes in aneurysmal subarachnoid hemorrhage" Journal of Neurosurgery October 2012
  • "Cell types and response properties of neurons in the ventral division of the medial geniculate body of the rabbit" Journal of Comparative Neurology March 25 2002
  • "Response" Journal of Neurosurgery April 2012
  • "Patient-specific cranial nerve identification using a discrete deformable contour model for skull base neurosurgery planning and simulation"   2016
  • "Dual Endoscopic Endonasal Transsphenoidal and Precaruncular Transorbital Approaches for Clipping of the Cavernous Carotid Artery" Journal of Neurological Surgery, Part B: Skull Base March 22 2016

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