Photo of Jonathan R. Lindner, M.D.

Jonathan R. Lindner M.D.

  • (503) 494-9191
    • Professor of Medicine, Division of Cardiovascular Medicine School of Medicine
    • Professor Oregon National Primate Research Center
    • M. Lowell Edwards Professor of Cardiology Medicine, Division of Cardiovascular Medicine School of Medicine
    • Director, Cardiovascular Imaging, Knight OHSU Knight Cardiovascular Institute School of Medicine
    • Chief, Division of Cardiometabolic Health Oregon National Primate Research Center
    • Biomedical Engineering Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Lindner is a Professor of Medicine at Oregon Health & Science University where he is the Director of Cardiovascular Imaging and holds the M. Lowell Edwards Professorship of Cardiology. He is also the Chief of the Division of Cardiometabolic Health at the Oregon National Primate Research Center.  He received his medical degree and residency training in internal medicine at the University of Texas Southwestern Medical School, and received his cardiovascular training at the University of Virginia.  Dr. Lindner has expertise in the fields of cardiovascular imaging and microvascular physiology; and is currently the principal investigator on several R01 grants from the National Institutes of Health and a grant from the NASA National Space and Biomedical Research Institute.  His research laboratory has pioneered the use of contrast ultrasound for non-invasive molecular imaging of disease and the evaluation of microvascular function/dysfunction.  Specific areas of research include: (a) application of molecular imaging techniques for early detection of atherosclerosis and evaluation of new therapies for atherosclerosis; (b) molecular imaging of angiogenesis and stem cell therapy; (c) molecular imaging for early diagnosis of myocardial ischemic injury and inflammation; (d) microvascular dysfunction and endothelial abnormalities in atherosclerosis, insulin resistance, and sickle cell disease; (e) development of new methods for detecting and treating peripheral arterial disease, and (f) novel approaches for therapeutic ultrasound. Dr. Lindner is the President Elect for the American Society of Echocardiography and also serves as an Associate Editor for the Journal of the American Society of Echocardiography.  He is on the Board of Directors and serves as the Vice-chair for the Exam Writing Committee for the National Board of Echocardiography.

Areas of interest

  • Non-invasive cardiovascular imaging
  • Molecular imaging
  • Atherosclerosis and ischemic heart disease
  • Microvascular function and dysfunction

Education

  • M.D., University of Texas Southwestern 1990
  • Residency:

    • University of Texas Southwestern Medical School, Dallas, Texas
  • Fellowship:

    • Cardiovascular medicine, University of Virginia, Charlottesville, Virginia
  • Certifications:

    • American Board of Internal Medicine, internal medicine (1993)
    • Echocardiography – National Board of Echocardiography

Honors and awards

  • Fellow, American College of Cardiology
  • Fellow, American Society of Echocardiography
  • Elected Member of the American Society of Clinical Investigation
  • Elected Member of the Association of University Cardiologists
  • American Society of Echocardiography, Richard J. Popp Excellence in Teaching Award

Memberships and associations

  • President Elect, American Society of Echocardiography
  • Board of Directors, National Board of Echocardiography
  • Vice-chair, Writing Committee, National Board of Echocardiography
  • NIH MEDI study section
  • NIH/NHLBI Data Safety Monitoring Board for Gene and Cell Therapy Trials
  • Association of University Cardiologists
  • American Society of Clinical Investigation

Publications

  • Belcik, JT, et al. Augmentation of muscle blood flow by ultrasound cavitation is mediated by ATP purinergic signaling. Circulation 2017.

  • Mott B, et al. J Am Coll Cardiol Cardiovasc Imag 2016;9:937-46

  • Xie A, et al. Influence of DNA-microbubble coupling on contrast ultrasound-mediated gene transfection in muscle and liver. J Am Soc Echocardiogr 2016;29:812-818.

  • Shim CY, et al. Molecular Imaging of platelet-endothelial interactions and endothelial Von Willebrand factor in early and mid-stage atherosclerosis. Circ Cardiovasc Imaging 2015;8:e002765.

  • Chadderdon SM, et al. Skeletal muscle capillary responses to endothelial-derived vasoactive pathways modulate obesity-related insulin resistance. Diabetes 2016;65:2249-57.

  • Liu Y, et al. Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis: effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging 2013;6:74-82.

  • Davidson BP, et al. Detection of antecedent myocardial ischemia with multi-selectin molecular imaging. J Am Coll Cardiol 2012;60:1690-1697.

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