Photo of Jonah B. Sacha, Ph.D.

Jonah B. Sacha Ph.D.

  • (503) 418-2774
    • Associate Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Sacha graduated cum laude from the University of Missouri-Columbia in 2003 with a B.A. in German and B.S. in Biology.  After receiving his Ph.D. in Medical Microbiology & Immunology from the University of Wisconsin-Madison in 2007, he joined the faculty at UW-Madison where he researched the characteristics of effective retrovirus-specific CD8+ and CD4+ T cells.  In 2011, he joined the Oregon Health & Science University and has appointments in both the Vaccine & Gene Therapy Institute and Oregon National Primate Research Center.

Areas of interest

  • T cell Biology
  • Retroviruses
  • Vaccine development

Education

  • B.S., University of Missouri, Columbia Missouri United States 2003
  • Ph.D., University of Wisconsin, Madison Wisconsin United States 2007

Honors and awards

  • 2013 - Creative and Novel Ideas in HIV Research Award
  • 2011 - AIDS Vaccine Conference Scholarship Award
  • 2011 - Young Investigator Editor for AIDS Research & Human Retroviruses
  • 2008 - Nonhuman Primate Symposium Young Investigator Scholarship
  • 2008 - University of Wisconsin-Madison Vilas Travel Scholarship
  • 2007 - Keystone Symposia: HIV Vaccines Young Investigator Scholarship
  • 2003 - National Science Foundation REU Graduate Fellowship
  • 2003 - Bachelor of Science with Departmental Honors
  • 2003 - Bachelor of Science with Honors, cum laude
  • 2003 - Bachelor of Arts with Honors, cum laude
  • 1997 - Rotary International Youth Ambassador to Germany
  • 1997 - Bright Flight Undergraduate Scholarship (maintained all years at University of Missouri)

Memberships and associations

  • Member, American Society of Microbiology
  • Member, Society for Leukocyte Biology
  • Member, International AIDS Society
  • Member, American Society of Hematology

Publications

  • "Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding." Nature Communications  In: , Vol. 9, No. 1, 3137, 01.12.2018.
  • "Erratum : Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding (Nature communications (2018) 9 1 (3137))." Nature communications  In: , Vol. 9, No. 1, 13.11.2018.
  • "The Role of MHC-E in T Cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques." Journal of Immunology  In: , Vol. 200, No. 1, 01.01.2018, p. 49-60.
  • "Combination adenovirus and protein vaccines prevent infection or reduce viral burden after heterologous clade C simian-human immunodeficiency virus mucosal challenge." Journal of Virology  In: , Vol. 92, No. 2, e01092-17, 01.01.2018.
  • "Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes." Nature Communications  In: , Vol. 8, No. 1, 1418, 01.12.2017.
  • "Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques /631/326/596/1550 /631/326/596/2555 /631/326/596/2557 article." Nature Communications  In: , Vol. 8, No. 1, 2146, 01.12.2017.
  • "Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers." Retrovirology  In: , Vol. 14, No. 1, 41, 22.08.2017.
  • "Erratum : Addendum: Immune clearance of highly pathogenic SIV infection (Nature (2013) 502 7469 (100-104))." Nature  In: , Vol. 547, No. 7661, 06.07.2017, p. 123-124.
  • "MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates." Mucosal Immunology  In: , Vol. 10, No. 3, 01.05.2017, p. 802-813.
  • "Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication." PLoS Pathogens  In: , Vol. 12, No. 12, e1006048, 07.12.2016.
  • "Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques." PLoS Pathogens  In: , Vol. 12, No. 11, e1006014, 01.11.2016.
  • "Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus." PLoS Pathogens  In: , Vol. 12, No. 8, e1005868, 01.08.2016.
  • "Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation." PLoS Pathogens  In: , Vol. 12, No. 6, e1005677, 01.06.2016.
  • "Achieving potent autologous neutralizing antibody responses against tier 2 HIV-1 viruses by strategic selection of envelope immunogens." Journal of Immunology  In: , Vol. 196, No. 7, 01.04.2016, p. 3064-3078.
  • "Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques." Nature Medicine  In: , Vol. 22, No. 4, 01.04.2016, p. 362-368.
  • "Strategies to target non-T-cell HIV reservoirs." Current Opinion in HIV and AIDS  In: , 25.03.2016.
  • "Broadly targeted CD8 T cell responses restricted by major histocompatibility complex E." Science  In: , Vol. 351, No. 6274, 12.02.2016, p. 714-720.
  • "Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease." Retrovirology  In: , 15.01.2016.
  • "Comparison of the superagonist complex, ALT-803, to IL15 as cancer immunotherapeutics in animal models." Cancer immunology research  In: , Vol. 4, No. 1, 01.01.2016, p. 49-60.
  • "TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection." PLoS Pathogens  In: , Vol. 12, No. 1, e1005349, 2016.
  • "Acute viral escape selectively impairs nef-mediated major histocompatibility complex class i downmodulation and increases susceptibility to antiviral t cells." Journal of Virology  In: , Vol. 90, No. 4, 2016, p. 2119-2126.
  • "Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection." Journal of Virology  In: , Vol. 89, No. 15, 2015, p. 7521-7535.
  • "Expansion of dysfunctional Tim-3 - Expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques." Journal of Immunology  In: , Vol. 193, No. 11, 01.12.2014, p. 5576-5583.
  • "Erratum : Immune clearance of highly pathogenic SIV infection (Nature (2013) 502 (100-104) DOI:10.1038/nature12519))." Nature  In: , Vol. 514, No. 7524, 30.10.2014, p. 654.
  • "Cutting edge : An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells." Journal of Immunology  In: , Vol. 193, No. 4, 15.08.2014, p. 1544-1548.
  • "Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication." PLoS One  In: , Vol. 9, No. 3, e92012, 20.03.2014.
  • "Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection." Retrovirology  In: , Vol. 11, No. 1, 10, 28.01.2014.
  • "Technical advance : Liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease." Journal of Leukocyte Biology  In: , Vol. 96, No. 3, 2014, p. 491-501.
  • "Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus." Journal of Virology  In: , Vol. 88, No. 6, 2014, p. 3598-3604.
  • "T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence." PLoS Pathogens  In: , Vol. 10, No. 5, e1004123, 2014.

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