John Butler

  • Current Program Year: MS4
  • Graduate Alum, Biomedical Engineering Graduate Program, School of Medicine
  • M.D./Ph.D. Program Students, School of Medicine

Biography

Dissertation Title: Extracellular vesicles trafficking enforces microenvironmental dysregulation in Acute Myeloid Leukemia (2020) 

John Butler, PhD, MLS(ASCP) is a certified Clinical Laboratory Scientist, with experience working in both Transfusion Medicine and Molecular Diagnostics prior to medical school. In 2015, John joined the MD/PhD program at OHSU to study medicine with additional training in cancer biology. As a member of the Kurre Lab/Marks Lab, John's dissertation research focued on how Acute Myelogenous Leukemia (AML) alters the bone marrow microenvironment to supress hematopoiesis and evade the immune system by inhibiting the activation of CD8+ T-cells. Following graduation, John plans to continue his training in the field of Radiation Oncology. His current hobbies include knowing things, learning things, and taking tests on things. He used to have other hobbies, but since starting his doctoral training, he can't seem to remember what they were. 

Education and training

    • B.S., 2013, University of Rhode Island
    • Ph.D., 2020, Oregon Health & Science University
  • Certifications

    • MLS(ASCP) | Rhode Island School Of Medical Technology, Providence, RI (2013)

Memberships and associations:

  • American Society for Radiation Oncology (ASTRO)
  • American Society of Hematology (ASH)

Areas of interest

  • Oncology
  • Tumor Immunology
  • Live-cell and super resolution fluorescence microscopy
  • Radiation Therapy

Honors and awards

  • NRSA F30 Fellowship Award (2019-2022), National Cancer Institute, NIH
  • Elected senior AOA (2021), Alpha Omega Alpha Medical Honors Society
  • Medical Scientist Training Program (MSTP) Trainee Award (2016-2017), NIH
  • Tartar Trust Grant Award (2018), OHSU
  • Bradley Sack Travel Award (2019), OHSU
  • Friends of Doernbecher Research Grant Award (2018-2019), Doernbecher Foundation
  • Global Research Education and Training Course Instructor (2019-present), OHSU Global/Mae Fuh Luong University (Chiang Rai, Thailand)

Publications

Selected publications

  • Butler, J.T., Hall, L.L., Smith, K., and  J.B. Lawrence. Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells. J Cell Biochem. 2009. 107 (4) PMID: 30206307
  • Harada A, Mallappa C, Okada S, Butler JT, Baker SP, Lawrence JB, Ohkawa Y, Imbalzano AN. Spatial re-organization of myogenic regulatory sequences temporally controls gene expression. Nucleic Acids Res. 2015 Feb 27;43(4):  PMID:    25653159
  • Butler, J.T., S. Abdelhamed, and P. Kurre. Extracellular vesicles in the hematopoietic microenvironment. Haematologica, 2018. 103(3): p. 382-394. PMC 5830368.
  • Butler, J.T. and P. Kurre. Transmissible ER stress shapes the leukemic microenvironmentOncotarget.  2019 May 5 10 (41), 4080-4082. PMID: 31289607
  • Abdelhamed, S., Butler, J.T., Doron, B., Halse, A.,  Nemecek, E.,  Wilmarth, P.A. Chang,B.H., Marks, D., Horton,T. and P. Kurre. Extracellular Vesicles Impose Quiescence on Residual Hematopoietic Stem Cells in the Leukemic Niche. EMBO Rep. 2019 Jun 16.  PMID: 31267709
  • Doron, B., Abdelhamed, S.,  Butler, J.T., Hashmi, S.K., Horton, T.M., and P. Kurre. Transmissible ER stress reconfigures the AML bone marrow compartment. Leukemia. 2019 Apr 33 (4), 918 PMID: 30206307
  • Nehrbas, J., Butler, J.T., Chen, D.W., and Kurre, P. Extracellular Vesicles and Chemotherapy Resistance in the AML Microenvironment. Front Oncol. 2020;10:90.  PMID: 32117744
  • Olson B, Zhu X, Norgard MA, Levasseur PR, Butler JT, Buenafe A, Burfeind KG, Michaelis KA, Pelz KR, Mendez H,Edwards J, Krasnow SM, Grossberg AJ, Marks DL. Lipocalin 2 mediates appetite suppression during pancreatic cancercachexia. Nature Communications. 2021 Apr 6;12(1):2057. PMID: 33824339
  • Abdelhamed S, Butler JT, Jung S, Chen, D, Gao L, Lim J, Klco JM, Horton TM, P Kurre. Rational biomarker developmentfor the early and minimally-invasive detection of AML. Blood Advances. 2021; accepted Aug 8, (ahead of print). 
  • Butler JT; Robinson T, Edwards J,  Grafe M and J Kirsch. Effects of prolonged peri-neural bupivacaine infusion in rat sciatic nerves (axon and myelin). Resorative Neurology and Neuroscience. 2021; accepted Aug 27 (ahead of print)

Publications

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