Photo of Jing Xu, Ph.D.

Jing Xu Ph.D.

  • (503) 346-5411
    • Assistant Professor of Obstetrics and Gynecology School of Medicine
    • Assistant Professor Oregon National Primate Research Center
    • Assistant Professor GT.Center for Embryonic Cell & Gene Therapy

Jing Xu is an Assistant Professor in the Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, School of Medicine, and the Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health &Science University (OHSU). She earned her Ph.D. degree in biochemistry and molecular biology, and obtained her postdoctoral training in neuroscience and reproductive science at OHSU. She was appointed as a BIRCWH (NIH/ORWH and NICHD Building Interdisciplinary Research Careers in Women's Health) Scholar and became a faculty member at OHSU in 2012.

Using a nonhuman primate model, her research investigates the production and direct actions of paracrine/autocrine factors, including peptide hormones (e.g., anti-Müllerian hormone, activin and vascular endothelial growth factor) and steroids (e.g., androgen and vitamin D), in ovarian follicles developed in vitro and in vivo. The goal is to unravel their roles in controlling follicular cell proliferation, differentiation and function. Data generated from the nonhuman primate studies could portend novel therapeutic approaches via manipulating local factors to regulate folliculogenesis clinically in women with ovarian dysfunction, including polycystic ovary syndrome.

For in vitro studies, her laboratory developed three-dimensional culture techniques to grow ovarian tissue and follicles achieving function in production of steroid hormones and peptide factors, as well as oocyte maturation for subsequent in vitro fertilization and early embryonic development. The culture system provides a valuable model to monitor and manipulate molecular signaling pathways and related factors to obtain knowledge of their roles and importance on ovarian follicle growth and steroidogenic/gametogenic functions. For in vivo studies, her research team uses intraovarian infusion technique achieving local delivery of target agents to study their actions in regulating follicle growth and selection in the ovary during the spontaneous menstrual cycle. Genetic manipulation approaches can be applied locally precluding complex systemic effects. The dynamics of the follicular development is monitored and evaluated chronologically via high-resolution transabdominal Doppler 3D ultrasonography.

While improving conditions for nonhuman primate ovarian tissue and follicle culture, translational efforts are made on human in vitro follicle maturation in collaboration with Dr. Tanja Pejovic in the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, School of Medicine, OHSU. By achieving the goal of producing competent oocytes, this technique may offer a means to enhance fertility preservation options in female patients facing ovarian toxic medical treatment, including cancer therapies.

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Areas of interest

  • Reproductive endocrinology and infertility
  • Fertility preservation in women
  • Ovarian biology and physiology
  • Ovarian follicular development and oocyte maturation
  • Ovarian tissue and follicle culture

Education

  • M.S., Biochemistry and Molecular Biology, Oregon Health & Science University, Portland Oregon United States 2003
  • M.S., Biochemistry and Molecular Biology, Oregon Health & Science University, Portland Oregon United States 2003
  • Ph.D., Biochemistry and Molecular Biology, Oregon Health & Science University, Portland Oregon United States 2006
  • Ph.D., Biochemistry and Molecular Biology, Oregon Health & Science University, Portland Oregon United States 2006
  • Fellowship:

    • Postdoctoral fellow in Neuroendocrinology, Oregon National Primate Research Center, 2006-2008
    • Postdoctoral fellow in Ovarian Biology, Oregon National Primate Research Center, 2008-2012

Honors and awards

  • NIH/NICHD Institutional Research Training Grant for Reproductive Biology (T32 HD007133), 2009
  • The Endocrine Society Travel Grant, 2010
  • The Federation of American Societies for Experimental Biology Trainee Travel Award, 2010
  • The Oncofertility Consortium Travel Award, 2011
  • The Oregon Health & Science University Research Mission Postdoctoral Fellow Excellence Award, 2012
  • The Larry Ewing Memorial Trainee Travel Fund, 2012
  • NIH/ORWH and NICHD Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Award (K12 HD043488), 2012-2015
  • The Society for the Study of Reproduction - World Congress of Reproductive Biology Travel Grant, 2014

Memberships and associations

  • Membership Committee, Society for the Study of Reproduction
  • Member, American Society for Reproductive Medicine
  • Member, European Society of Human Reproduction and Embryology

Publications

  • Xu J, Bishop CV, Lawson MS, Park BS, Xu F. Anti-Müllerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates. Human Reproduction, 31:1522-1530, 2016. PMID: 27165618.

  • Xu J, Hennebold JD, Seifer DB. Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid and anti-Müllerian hormone production. Fertility and Sterility, 106:1815-1820, 2016. PMID: 27678030.

  • Xu J, Xu F, Letaw JH, Park BS, Searles RP, Ferguson BM. Anti-Müllerian hormone is produced heterogeneously in the population of primate preantral follicles, and is a potential biomarker for follicle growth and oocyte maturation in vitro. Journal of Assisted Reproduction and Genetics, 33:1665-1675, 2016. PMID: 27638727.

  • Xu J, McGee WK, Bishop CV, Park BS, Cameron JL, Zelinski MB, Stouffer RL. Exposure of female macaques to Western-style diet with or without chronic testosterone in vivo alters secondary follicle function during encapsulated 3-dimensional culture. Endocrinology, 156, 1133-1142, 2015. PMID: 25545382.

  • Rodrigues JK, Navarro PA, Zelinski MB, Stouffer RL, Xu J. Direct actions of androgens on the survival, growth and secretion of steroids and anti-Müllerian hormone by individual macaque follicles during 3-dimentional culture. Human Reproduction, 30, 664-674, 2015. PMID: 25567619.

  • Xu J, Xu M, Bernuci MP, Fisher TE, Shea LD, Woodruff TK, Zelinski MB, Stouffer RL. Primate follicular development and oocyte maturation in vitro. Advances in Experimental Medicine and Biology, 761, 43-67, 2013. PMID: 24097381.

  • Xu J, Lawson MS, Yeoman RR, Molskness TA, Ting AY, Stouffer RL, Zelinski MB. Fibrin promotes development and function of macaque primary follicles during encapsulated three-dimensional culture. Human Reproduction, 28, 2187-2200, 2013. PMID: 23608357.

  • Fisher TE, Molskness TA, Villeda A, Zelinski MB, Stouffer RL, Xu J. Vascular endothelial growth factor and angiopoietin production by primate follicles during culture is a function of growth rate, gonadotropin exposure and oxygen milieu. Human Reproduction, 28, 3263-3270, 2013. PMID: 24045779.

  • Xu J, Lawson MS, Yeoman RR, Pau KY, Barrett SL, Zelinski MB, Stouffer RL. Secondary follicle growth and oocyte maturation during encapsulated three-dimensional culture in rhesus monkeys: effects of gonadotropins, oxygen, and fetuin. Human Reproduction, 26, 1061-1072, 2011. PMID: 213626981.

  • Xu J, Bernuci MP, Lawson MS, Yeoman RR, Fisher TE, Zelinski MB, Stouffer RL. Survival, growth, and maturation of secondary follicles from prepubertal, young and older adult, rhesus monkeys during encapsulated three-dimensional (3D) culture: effects of gonadotropins and insulin. Reproduction, 140, 685-697, 2010. PMID: 20729335.

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