Photo of Jessica Minnier, Ph.D

Jessica Minnier Ph.D

  • (503) 494-3967

    Portland Campus

    • Assistant Professor OHSU-PSU School of Public Health
    • Assistant Professor OHSU-PSU School of Public Health
    • Faculty, Biostatistics Shared Resource, Knight Cancer Institute
    • OHSU Knight Cardiovascular Institute School of Medicine
    • IG.Integrated Genomics

Jessica Minnier is an assistant professor of biostatistics in the School of Public Health and is also affiliated with the Knight Cardiovascular Institute and the Knight Cancer Institute’s Biostatistics Shared Resource.

Dr. Minnier maintains a comprehensive statistical research program focusing on the development and evaluation of risk prediction models as well as the analysis of high dimensional data. During her doctoral studies at Harvard University, she developed novel statistical methodology that uses machine-learning techniques to quantify a subject’s risk for disease based on a large number of genetic markers as well as environmental and clinical predictors. As a post-doctoral research fellow at the Fred Hutchinson Cancer Research Institute, she collaborated with geneticists and epidemiologists to analyze genomic and epidemiological data to study colorectal cancer pathogenesis.

Dr. Minnier is committed to research that addresses statistical issues related to  risk assessment and the role of clinical and genetic predictors in the etiology of disease.

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Education

  • B.A., Lewis & Clark College, Portland Oregon 2007
  • M.A., Harvard University 2009
  • Ph.D., Harvard University 2012

Honors and awards

  • 2012, Finalist Best Statistics Student Paper Award, American Public Health Association
  • 2011, David P. Byar Travel Award for the Joint Statistical Meetings, American Statistical Association Biometrics Section
  • 2011, Rose Traveling Fellowship in Chronic Disease Epidemiology & Biostatistics, Harvard School of Public Health
  • 2011, Distinguished Student Paper Award, ENAR International Biometrics Society
  • 2006, Barry M. Goldwater Scholar
  • 2011, Distinguished Teaching Award, Harvard School of Public Health
  • 2007, Phi Beta Kappa, Lewis & Clark College
  • 2018, NASA Datanaut

Publications

  • "Risk Classification With an Adaptive Naive Bayes Kernel Machine Model" Journal of the American Statistical Association January 2 2015
  • "A perturbation method for inference on regularized regression estimates" Journal of the American Statistical Association December 2011
  • "Using electronic medical records to enable large-scale studies in psychiatry" Psychological Medicine January 2012
  • "Gene-environment interaction involving recently identified colorectal cancer susceptibility loci" Cancer Epidemiology Biomarkers and Prevention September 1 2014
  • "Assessing Population Level Genetic Instability via Moving Average" Statistics in Biosciences December 2010
  • "PCSK9 Association With Lipoprotein(a)" Circulation Research April 29 2016
  • "Validation of electronic health record phenotyping of bipolar disorder cases and controls" American Journal of Psychiatry April 1 2015
  • "Discordant response of low-density lipoprotein cholesterol and lipoprotein(a) levels to monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9" Journal of Clinical Lipidology January 13 2017
  • "Extended multiplexing of tandem mass tags (TMT) labeling reveals age and high fat diet specific proteome changes in mouse epididymal adipose tissue" Molecular and Cellular Proteomics May 1 2017
  • "Reproducible and reusable research" PeerJ  2017
  • "Magnetic resonance imaging in patients with cardiac implantable electronic devices" Journal of Interventional Cardiac Electrophysiology July 22 2017
  • "Increased Coronary Tortuosity Is Associated with Increased Left Ventricular Longitudinal Myocardial Shortening" Journal of the American Society of Echocardiography  2017
  • "Threshold Effects of Circulating Angiopoietin-Like 3 Levels on Plasma Lipoproteins" Journal of Clinical Endocrinology and Metabolism September 1 2017
  • "The START App" Bioinformatics January 1 2017
  • "Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension" Physiological Genomics February 1 2018
  • "Improving sudden cardiac death risk stratification by evaluating electrocardiographic measures of global electrical heterogeneity and clinical outcomes among patients with implantable cardioverter-defibrillators" Journal of Interventional Cardiac Electrophysiology March 14 2018
  • "Standardized Goal-Directed Valsalva Maneuver for Assessment of Inducible Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy" Journal of the American Society of Echocardiography January 1 2018
  • "Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records" Translational Psychiatry December 1 2018
  • "RNA-seq and expression arrays"  January 1 2018
  • "Self-regulated use of a wearable activity sensor is not associated with improvements in physical activity, cardiometabolic risk or subjective health status" British Journal of Sports Medicine December 8 2017
  • "GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate" Scientific Reports December 1 2018
  • "Hospitalization trends and health resource use for adult congenital heart disease-related heart failure" Journal of the American Heart Association August 1 2018
  • "Bortezomib-based Chemotherapy for Multiple Myeloma Patients Without Comorbid Cardiovascular Disease Shows No Cardiotoxicity" Clinical Lymphoma, Myeloma and Leukemia January 1 2018
  • "Erratum to" Methods in molecular biology (Clifton, N.J.) January 1 2018
  • "Application of PCSK9 Inhibitors in Practice" Circulation Research January 4 2019
  • "Relationship Between Low-Density Lipoprotein Cholesterol and Lipoprotein(a) Lowering in Response to PCSK9 Inhibition With Evolocumab" Journal of the American Heart Association February 19 2019
  • "Physiologically activated mammary fibroblasts promote postpartum mammary cancer" JCI insight March 23 2017
  • "Effect of impact factor and discipline on journal data sharing policies" Accountability in Research January 1 2019
  • "Automated feature selection of predictors in electronic medical records data" Biometrics January 1 2018
  • "Impact of PCSK9 inhibitors on plasma lipoprotein(a) concentrations with or without a background of niacin therapy" Journal of Clinical Lipidology January 1 2019

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