Photo of James Maylie, Ph.D.

James Maylie Ph.D.

    • Professor of Obstetrics and Gynecology School of Medicine
    • Neuroscience Graduate Program School of Medicine

Dr. Maylie received his Ph.D. from UO Medical School (now OHSU) in 1977 in physiology and completed a post-doctoral fellowship with Dr. Martin Morad at University of Pennsylvania. He was an Associate Research Assistant in the Department of Physiology at Yale University for 5 years prior to relocating to OHSU. Dr. Maylie’s lab primary focus is in the field of neurobiology. He was trained in electrophysiology and Ca2+ imaging and has merged these techniques along with molecular techniques to study fundamental issues in neuroscience. With his collaborator, Dr. John Adelman in the Vollum Institute at OHSU, they have taken advantage of the explosion in the field of neurobiology that occurred in the 1980s and 1990s with the ability to clone and heterologously express functional ion channels and develop transgenic mice. Over the years Dr. Maylie’s laboratory has become truly multi-dimensional employing a wide repertoire of techniques to address fundamental issues in neuroscience.

Education

  • B.A., Willamette University, Salem Oregon 1969
  • B.S., Stanford University 1971
  • Ph.D., University of Oregon Medical School 1977
  • Fellowship:

    • Postdoctoral fellow with Dr. Martin Morad, Department of Physiology, University of Pennsylvania, 1980

Publications

  • "Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents" Journal of Neuroscience June 9 2004
  • "Inhibition of I(Ks) in guinea pig cardiac myocytes and guinea pig I(sK) channels by the chromanol 293B" Pflugers Archiv European Journal of Physiology  1996
  • "Angiotensin II stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocytes" Journal of Physiology May 1 2003
  • "Distinct Ca2+ sources in dendritic spines of hippocampal CA1 Neurons Couple to SK and Kv4 Channels" Neuron January 22 2014
  • "Evidence for a deep pore activation gate in small conductance Ca 2+-activated K+ channels" Journal of General Physiology December 2007
  • "Episodic ataxia mutations in Kv1.1 alter potassium channel function by dominant negative effects or haploinsufficiency" Journal of Neuroscience April 15 1998
  • "Mechanism of calcium gating in small-conductance calcium-activated potassium channels" Nature October 1 1998
  • "Apamin boosting of synaptic potentials in CaV2.3 R-type Ca2+ channel null mice" PLoS One September 29 2015
  • "A study of pace-marker potential in rabbit sino-atrial node" Journal of Physiology  1981
  • "Comparison of the rate-dependent properties of the Class III antiarrhythmic agents Azimilide (NE-10064) and E-4031" Journal of Cardiovascular Electrophysiology  1997
  • "Gating of recombinant small-conductance Ca-activated K+ channels by calcium" Journal of General Physiology April 1998
  • "Small-conductance calcium-activated potassium currents in mouse hyperexcitable denervated skeletal muscle" Journal of Physiology October 15 2001
  • "A human intermediate conductance calcium-activated potassium channel" Proceedings of the National Academy of Sciences of the United States of America October 14 1997
  • "Ionic currents responsible for the generation of paceâ€�maker current in the rabbit sinoâ€�atrial node." Journal of Physiology October 1 1984
  • "Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity" Journal of Neuroscience February 8 2006
  • "A novel isoform of SK2 assembles with other SK subunits in mouse brain" Journal of Biological Chemistry June 3 2005
  • "Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors" Journal of Neuroscience September 1 2010
  • "Small conductance Ca2+-activated K+ channels and calmodulin" Journal of Physiology January 15 2004
  • "Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses" Journal of Neuroscience  2013
  • "Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation" European Journal of Neuroscience October 1 2014
  • "Developmental profile of SK2 channel expression and function in CA1 neurons" Hippocampus June 2012
  • "Ionic characterization of pacemaker current in voltage clamped rabbit SA node" Biophysical Journal  1981
  • "Right ventricular systolic pressure load alters myocyte maturation in fetal sheep" American Journal of Physiology - Renal Fluid and Electrolyte Physiology  2000
  • "Domains responsible for constitutive and Ca2+-dependent interactions between calmodulin and small conductance Ca2+-activated potassium channels" Journal of Neuroscience October 15 1999
  • "Beam me up, Scottie! Trek channels swing both ways" Nature Neuroscience  2001
  • "Episodic ataxia type-1 mutations in the hKv1.1 cytoplasmic pore region alter the gating properties of the channel" EMBO Journal March 2 1998
  • "A mouse model of episodic ataxia type-1" Nature Neuroscience April 1 2003
  • "Episodic ataxia results from voltage-dependent potassium channels with altered functions" Neuron  1995
  • "SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines" Nature Neuroscience May 2005
  • "Excitation-contraction coupling in neonatal and adult myocardium of cat." American Journal of Physiology - Renal Fluid and Electrolyte Physiology May 1982

Additional information

Edit profile