Photo of Holly L. Rosenzweig, Ph.D.

Holly L. Rosenzweig Ph.D.

  • (503) 220-8262
    • Associate Professor of Molecular Microbiology and Immunology School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

We are interested in understanding how innate immune pathways and cellular processes are involved in tissue injury and diseases such as arthritis and/or uveitis. 

Professional Affiliations:

Association for Research in Vision and Ophthalmology Association of Rheumatology Health Professionals

Professional Experience:

Postdoctoral fellowship: Ocular inflammation, Oregon Heath & Science University, mentor: James Rosenbaum, 2006-2009 Assistant Professor: Ophthalmology, Oregon Heath & Science University, 2009-present Adjunct faculty: Molecular Microbiology & Immunology, Oregon Heath & Science University, 2009-present

Selected, recent publications

Rosenzweig HL, Martin, TM, Jann MM, Planck SR, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci (2008); 49(4): 1518-24. Rosenbaum JT, Rosenzweig HL, Smith JR, Martin TM, Planck SR. Uveitis secondary to bacterial products. Ophthalmic Res (2008); 40(3-4): 165-8. Rosenzweig HL, Martin TM, Planck SR, Jann MM, Smith JR, Glant TT, van Eden W, Davey MP, Rosenbaum JT. Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis. Ophthalmic Res (2008); 40(3-4): 189-92. Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. Activation of NOD2 in vivo induced IL-1 beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol (2008); 84(2): 529-36 Rosenzweig HL, Galster KT, Planck SR, Rosenbaum JT. NOD1 is expressed in the eye and functionally contributes to IL-1& beta; dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci (2008); 50(4): 1746-53. Rosenzweig HL, Kawagushi T, Martin TM, Planck SR, Davey MP, Rosenbaum JT. Nucleotide Oligomerization Domain-2 (NOD2)-Induced Uveitis is Dependent on IFN?. Invest Ophthalmol Vis Sci (2008); 50(4): 1739-45. Rosenzweig HL, Jann MM, Glant TT, Martin TM, Planck SR, van Eden W, van Kooten PJS, Flavell RA, Kobayashi K, Rosenbaum JT, Davey MP. Activation of Nucleotide Oligomerization Domain Two Exacerbates a Murine Model of Proteoglycan-Induced Arthritis. J Leukoc Biol (2009); 85(4): 711-18. Rosenzweig HL, Jann MJ, Vance EE, Planck SR, Rosenbaum JT, Davey MP. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Arthritis Rheum (2010); 62(4): 1051.

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Areas of interest

  • Innate Immunity
  • Autoimmune uveitis and arthritis

Education

  • B.S., University of Colorado at Boulder, Boulder Colorado 1998
  • Ph.D., Oregon Health & Science University, Portland Oregon 2006
  • Fellowship:

    • Postdoctoral fellowship: Ocular inflammation, Oregon Health &Science University, 2006-2009

Memberships and associations

  • Association for Research in Vision and Ophthalmology

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