Biography
Probing Functional Mechanisms in Channels and Transporters
We are investigating functional mechanisms that govern molecular recognition and conformational dynamics in ion channels and transporters. In our investigations, we use a multidisciplinary approach that combines unnatural mutagenesis with structural studies using x-ray crystallography. We also carry out functional measurements using electrophysiology and investigate protein dynamics using EPR and fluorescence spectroscopy.
Education and training
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- B.S., 1990, Chemistry, University of Mumbai, India
- M.S., 1992, Biotechnology, IIT-Mumbai, India
- Ph.D., 1999, Biomolecular Chemistry, University of Wisconsin-Madison
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Fellowship
- 2005 Postdoctoral (Molecular Neurobiology and Peptide Chemistry), Rockefeller University
Areas of interest
- Unnatural amino acid mutagenesis of membrane proteins
- Ion conduction and voltage gating in K+ channels
- Transport mechanism in glutamate transporters
- Folding of membrane proteins
Additional information
Honors and awards
- 2007 - Pew Scholar Award
- 1992 - Cremer Research Fellowship
Publications
Publications
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