Photo of Eric S. Orwoll, M.D.

Eric S. Orwoll M.D.

    • Professor of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition School of Medicine

Dr. Orwoll specializes in the evaluation and care of patients with osteoporosis, other forms of metabolic bone disorders, and abnormalities of calcium metabolism. He is professor of medicine and attending physician in the bone and mineral section of the Division of Endocrinology, Diabetes, and Clinical Nutrition, and has been the director of the Bone and Mineral Clinic, and of the Bone Density Lab.

He is an internationally recognized expert in the area of bone biology and metabolic bone disease, and has considerable experience in basic, clinical, and epidemiological investigation. Major areas of research interest include the epidemiology, etiology and therapy of osteoporosis in men, the evaluation of new diagnostics and therapeutics, osteogenesis imperfecta, effects of sex steroids on skeletal biology, and skeletal genetics/proteomics.

He has been the principle investigator for many projects supported by the National Institutes of Health, VA and foundations, and is the author of more than 400 peer reviewed publications, reviews, books, and book chapters. He is also an experienced leader in academic medicine who has had extensive responsibility for clinical and translational research planning and management. He has been the associate vice-president for research at OHSU, associate dean for clinical research in the School of Medicine, and the director of the Oregon Clinical and Translational Research Institute. Dr. Orwoll receives research support from the National Institutes of Health, the Osteogenesis Imperfecta Foundation, Merck, and Eli Lilly.

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  • Residency:

    • Medicine-Providence Medical Center, Portland
  • Fellowship:

    • Endocrinology-Oregon Health & Science University, Portland
  • Certifications:

    • Internal medicine, endocrinology, and metabolism


  • "Low Serum Testosterone and High Serum Estradiol Associate With Lower Extremity Peripheral Arterial Disease in Elderly Men. The MrOS Study in Sweden" Journal of the American College of Cardiology September 11 2007
  • "Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus" Journal of the American Geriatrics Society July 2011
  • "Efficacy and safety of monthly ibandronate in men with low bone density" Bone April 2010
  • "Estimated lean mass and fat mass differentially affect femoral bone density and strength index but are not frax independent risk factors for fracture" Journal of Bone and Mineral Research February 1 2014
  • "Methods and reliability of radiographic vertebral fracture detection in older men" Bone  2014
  • "Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men" Osteoporosis International April 2011
  • "Erratum" Journal of Clinical Endocrinology and Metabolism October 1 2014
  • "Fracture risk and zoledronic acid in men with osteoporosis." New England Journal of Medicine February 28 2013
  • "Creating an Institutional Resource for Research Education and Career Development" Clinical and Translational Science  2014
  • "The milk-alkali syndrome" Annals of Internal Medicine  1982
  • "Men, bone and estrogen" Osteoporosis International  2003
  • "Vitamin D and DBP" Journal of Steroid Biochemistry and Molecular Biology  2014
  • "BMD and risk of hip and nonvertebral fractures in older men" Journal of Bone and Mineral Research October 2006
  • "Water fluoridation [2] (multiple letters)" BMJ (Online) June 16 2001
  • "Hip fracture in women without osteoporosis" Journal of Clinical Endocrinology and Metabolism May 2005
  • "Depression and bone mineral density" Osteoporosis International June 2005
  • "Homologous androgen receptor up-regulation in osteoblastic cells may be associated with enhanced functional androgen responsiveness" Endocrinology  1999
  • "Insulin sensitizers may attenuate lean mass loss in older men with diabetes" Diabetes Care November 2011
  • "Kidney function and cognitive performance and decline in older men" Journal of the American Geriatrics Society November 2008
  • "Estimates of the proportion of older white men who would be recommended for pharmacologic treatment by the new US national osteoporosis foundation guidelines" Journal of Bone and Mineral Research July 2010
  • "Gender differences in the skeleton" Journal of Women's Health  1995
  • "Population-based fracture risk assessment and osteoporosis treatment disparities by race and gender" Journal of General Internal Medicine  2009
  • "Images in clinical medicine. Adults with osteogenesis imperfecta." New England Journal of Medicine December 28 2006
  • "Assessing bone density in men" Journal of Bone and Mineral Research  2000
  • "Functional polymorphisms affecting the clinically important arginine-137 residue of AVPR2 do not influence serum sodium concentration at the population level" Physiological Genomics  2013
  • "Mid-molecule parathyroid hormone assay comparison" Clinical Biochemistry  1986
  • "Bisphosphonates" American Family Physician May 1 2000
  • "The authors reply" New England Journal of Medicine February 28 2013
  • "Prediction Models of Prevalent Radiographic Vertebral Fractures Among Older Men" Journal of Clinical Densitometry  2014
  • "Serum estradiol is associated with lean mass in elderly Swedish men" European Journal of Endocrinology April 1 2010

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