Photo of David M. Koeller, M.D.

David M. Koeller M.D.

  • (503) 494-8307
    • Professor of Molecular and Medical Genetics School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Koeller has a diverse research background that includes basic studies of yeast mitochondrial iron metabolism, mammalian cellular iron metabolism, and the development and characterization of a mouse model of Glutaric Acidemia Type 1 (GA-I), an inherited disorder of lysine metabolism.

His current research includes an epidemiologic study of the possible impact of traditional Alaska Native foods on the health effects of a genetic variant in the CPT1A gene that he has previously shown to be a risk factor for infectious diseases and infant mortality in Alaska Native infants.

Dr. Koeller is also the Co-PI of the Metabolomics Core for the NIH Undiagnosed Disease Network. The Metabolomics Core is a joint project with investigators at the US Department of Energy’s Pacific Northwest National Laboratory, in Richland, WA.

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Education

  • M.D., University of Illinois James Scholar Program 1982
  • Residency:

    • University of Minnesota, Minneapolis, MN
  • Fellowship:

    • Fellowship in research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
  • Certifications:

    • American Board of Pediatrics, 1988

Memberships and associations

  • American College of Medical Genetics & Genomics,

Publications

  • "Therapeutic modulation of cerebral l-lysine metabolism in a mouse model for glutaric aciduria type I" Brain January 2011
  • "Lysine intake and neurotoxicity in glutaric aciduria type I" Brain August 2006
  • "Biochemical, pathologic and behavioral analysis of a mouse model of glutaric acidemia type 1" Human Molecular Genetics February 15 2002
  • "The mitochondrial ABC transporter Atm1p functions as a homodimer" FEBS Letters July 2 2004
  • "Bioenergetics in glutaryl-coenzyme A dehydrogenase deficiency" Journal of Biological Chemistry June 10 2005
  • "A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA." Proceedings of the National Academy of Sciences of the United States of America May 1989
  • "Introduction of H-2D(d) determinants into the H-2L(d) antigen by site-directed mutagenesis" Journal of Experimental Medicine  1987
  • "Challenges for basic research in glutaryl-CoA dehydrogenase deficiency" Journal of Inherited Metabolic Disease  2004
  • "Translation and the stability of mRNAs encoding the transferrin receptor and c-fos" Proceedings of the National Academy of Sciences of the United States of America  1991
  • "MDL1 is a high copy suppressor of ATM1" Journal of Molecular Biology August 1 2003
  • "Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1" Biochimica et Biophysica Acta - Molecular Basis of Disease October 2013
  • "Iron-responsive elements" Science  1988
  • "Identification of an RNA binding site for human thymidylate synthase" Proceedings of the National Academy of Sciences of the United States of America January 15 1993
  • "Glutaric aciduria type 1 metabolites impair the succinate transport from astrocytic to neuronal cells" Journal of Biological Chemistry May 20 2011
  • "Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1" Biochimica et Biophysica Acta - Molecular Basis of Disease June 2008
  • "Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening" EMBO Journal  1994
  • "Marked reduction of Na+, K+-ATPase and creatine kinase activities induced by acute lysine administration in glutaryl-CoA dehydrogenase deficient mice" Molecular Genetics and Metabolism September 2012
  • "Excitotoxicity and bioenergetics in glutaryl-CoA dehydrogenase deficiency" Journal of Inherited Metabolic Disease  2004
  • "Reply" Journal of Pediatrics  2014
  • "Multifactorial modulation of susceptibility to l-lysine in an animal model of glutaric aciduria type I" Biochimica et Biophysica Acta - Molecular Basis of Disease May 1 2015
  • "Evaluation of the structure function relationships of MHC class I antigens by molecular genetic techniques." The Year in immunology  1986
  • "Complementary dietary treatment using lysine-free, arginine-fortified amino acid supplements in glutaric aciduria type I - A decade of experience" Molecular Genetics and Metabolism September 2012
  • "Cloning, Structure, and Chromosome Localization of the Mouse Glutaryl-CoA Dehydrogenase Gene" Genomics August 10 1995
  • "Post-transcriptional regulation of the human transforming growth factor-β1 gene" Journal of Biological Chemistry July 5 1992
  • "Hypertension and renal failure in a patient with tuberous sclerosis" Southern Medical Journal  1990
  • "Impaired fasting tolerance among Alaska native children with a common carnitine palmitoyltransferase 1A sequence variant" Molecular Genetics and Metabolism November 2011
  • "Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I" Journal of Inherited Metabolic Disease  2004
  • "Guideline for the diagnosis and management of glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I)" Journal of Inherited Metabolic Disease February 2007
  • "Natural history, outcome, and treatment efficacy in children and adults with glutaryl-CoA dehydrogenase deficiency" Pediatric Research June 2006
  • "Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)" Human Molecular Genetics  1999

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