Photo of David H. Farrell, Ph.D., F.A.H.A.

David H. Farrell Ph.D., F.A.H.A.

  • (503) 494-8602
    • Professor of Surgery, Division of Trauma, Critical Care and Acute Care Surgery School of Medicine
    • Founder and Chief Scientific Officer, Gamma Therapeutics Inc.
    • Program in Molecular and Cellular Biosciences School of Medicine

Areas of interest

  • Blood Coagulation
  • Fibrinogen Biology
  • Hemostasis and Thrombosis
  • Protein Biochemistry

Education

  • B.S., UCLA, Los Angeles California 1979
  • Ph.D., University of California, Irvine California 1986
  • Fellowship:

    • Oregon Health Sciences University, Portland, Oregon 1986
    • University of Washington, Seattle, Washington 1993

Honors and awards

  • Fellow, American Heart Association

Memberships and associations

  • American Heart Association
  • International Fibrinogen Research Society
  • International Society on Thrombosis and Haemostasis
  • Editorial Board, Journal of Hematology Research

Publications

  • "The RGD sequence on the Aα Chain of fibrinogen is essential for binding to its erythrocyte receptor." International Journal of Nanomedicine In: , Vol. 13, 03.04.2018, p. 1985-1992.
  • "The platelet integrin αiIbβ3 differentially interacts with fibrin versus fibrinogen." Journal of Biological Chemistry In: , Vol. 291, No. 15, 08.04.2016, p. 7858-7867.
  • "Lucky 13." Blood In: , Vol. 126, No. 20, 12.11.2015, p. 2261-2262.
  • "Primetime for γ′." Blood In: , Vol. 124, No. 9, 28.08.2014, p. 1389-1390.
  • "Prognostic utility of biochemical markers of cardiovascular risk : Impact of biological variability." Clinical Chemistry and Laboratory Medicine In: , Vol. 51, No. 9, 09.2013, p. 1875-1882.
  • "Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based lifestyle intervention : A randomized controlled study." Journal of Pediatrics  In: , Vol. 163, No. 2, 08.2013, p. 333-338.
  • "Differential regulation of fibrinogen γ chain splice isoforms by interleukin-6." Thrombosis Research In: , Vol. 131, No. 1, 01.2013, p. 89-93.
  • "γ′ Fibrinogen as a novel marker of thrombotic disease." Clinical Chemistry and Laboratory Medicine In: , Vol. 50, No. 11, 11.2012, p. 1903-1909.
  • "Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition." Journal of Medicinal Chemistry In: , Vol. 55, No. 15, 09.08.2012, p. 6888-6897.
  • "Role of electrostatic interactions in binding of thrombin to the fibrinogen γ′ chain." Biochemistry In: , Vol. 51, No. 16, 24.04.2012, p. 3445-3450.
  • "Assessment of genetic determinants of the association of γ′ fibrinogen in relation to cardiovascular disease." Arteriosclerosis, Thrombosis, and Vascular Biology In: , Vol. 31, No. 10, 10.2011, p. 2345-2352.
  • "Association between γ'fibrinogen levels and inflammation." Thrombosis and Haemostasis In: , Vol. 105, No. 4, 04.2011, p. 605-609.
  • "Severe bleeding in a woman heterozygous for the fibrinogen γr275C mutation." Blood Coagulation and Fibrinolysis In: , Vol. 21, No. 5, 07.2010, p. 494-497.
  • "γ′ fibrinogen : Evaluation of a new assay for study of associations with cardiovascular disease." Clinical Chemistry In: , Vol. 56, No. 5, 01.05.2010, p. 781-788.
  • "γA/γ′ fibrinogen inhibits thrombin-induced platelet aggregation." Thrombosis and Haemostasis In: , Vol. 100, No. 5, 11.2008, p. 837-846.
  • "A novel highly porous silica and chitosan-based hemostatic dressing is superior to HemCon and gauze sponges." The Journal of trauma In: , Vol. 65, No. 4, 10.2008.
  • "A novel highly porous silica and chitosan-based hemostatic dressing is superior to hemcon and gauze sponges." Journal of Trauma - Injury, Infection and Critical Care In: , Vol. 65, No. 4, 10.2008, p. 884-890.
  • "New risk factor for venous thromboembolism?" Thrombosis and Haemostasis In: , Vol. 100, No. 2, 08.2008, p. 173-174.
  • "Fibrinogen Hershey IV : A novel dysfibrinogen with a γV411I mutation in the integrin αIIbβ3 binding site." Thrombosis and Haemostasis In: , Vol. 99, No. 6, 06.2008, p. 1008-1012.
  • "Fibrinogen γ′ chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway." British Journal of Haematology In: , Vol. 139, No. 3, 11.2007, p. 494-503.
  • "Incorporation of fibrin molecules containing fibrinopeptide A alters clot ultrastructure and decreases permeability." British Journal of Haematology In: , Vol. 138, No. 1, 07.2007, p. 117-124.
  • "Elevated plasma fibrinogen γ′ concentration is associated with myocardial infarction : Effects of variation in fibrinogen genes and environmental factors." Journal of Thrombosis and Haemostasis In: , Vol. 5, No. 4, 04.2007, p. 766-773.
  • "The fibrinogen Aα R16C mutation results in fibrinolytic resistance." British Journal of Haematology In: , Vol. 134, No. 2, 07.2006, p. 220-226.
  • "Conformational analysis of γ′ peptide (410-427) interactions with thrombin anion binding exosite II." Biochemistry In: , Vol. 45, No. 24, 20.06.2006, p. 7434-7445.
  • "Fibrinogen containing γ′ chains [3]." Blood In: , Vol. 107, No. 7, 01.04.2006, p. 3011-3012.
  • "Pathophysiologic roles of the fibrinogen gamma chain." Current Opinion in Hematology In: , Vol. 11, No. 3, 05.2004, p. 151-155.
  • "Influence of γ′ Fibrinogen Splice Variant on Fibrin Physical Properties and Fibrinolysis Rate." Arteriosclerosis, Thrombosis, and Vascular Biology In: , Vol. 24, No. 2, 02.2004, p. 382-386.
  • "Complete sequence of virulence plasmid pJM1 from the marine fish pathogen Vibrio anguillarum strain 775." Journal of Bacteriology In: , Vol. 185, No. 19, 10.2003, p. 5822-5830.
  • "Fibrinogen γ' chain binds thrombin exosite II." Journal of Thrombosis and Haemostasis In: , Vol. 1, No. 1, 01.2003, p. 124-131.
  • "Incorporation of vitronectin into fibrin clots. Evidence for a binding interaction between vitronectin and γA/γ′ fibrinogen." Journal of Biological Chemistry In: , Vol. 277, No. 9, 01.03.2002, p. 7520-7528.

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