Photo of Daniel L. Marks, M.D., Ph.D.

Daniel L. Marks M.D., Ph.D.

    • Professor of Pediatrics School of Medicine
    • Senior Associate Dean for Research Office of the Dean School of Medicine
    • Director of Patient Resiliency Program Brenden-Colson Center for Pancreatic Care School of Medicine
    • Credit Union for Kids Professor of Pediatric Research Pediatrics School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Physiology and Pharmacology Graduate Program School of Medicine

Dr. Marks' special interests are weight regulation in children, particulary involuntary weight loss or poor growth in chronic dieseases (cachexia, failure to thrive). His clinical areas of interest are all aspects of pediatric endocrinology (including growth, puberty, thyroid, diabetes and adrenal disorders), pediatric obesity and failure to thrive.

Dr. Marks received both his medical degree and Ph.D. in 1995 from the University of Washington in Seattle. Dr. Marks completed his residency at the University of Utah, SLC in 1998, followed by a fellowship in pediatric endocrinology at Oregon Health & Science University in 2001. Dr. Marks is currently the Senior Associate Dean for Research in the School of Medicine, Associate Director of the OHSU MD, PhD program, Director of the Patient Resiliency Program for the Brenden-Colson Center for Pancreatic Care and the Director of the Papé Family Pediatric Research Institute at Oregon Health & Science University in Portland, OR. Dr. Marks also served as a Consulting Senior Scientific Advisor for the Bill & Melinda Gates Foundation.

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Areas of interest

  • patient resiliency
  • cachexia
  • failure to thrive
  • fatigue


  • Ph.D., University of Washington School of Medicine, Seattle Washington 1993
  • M.D., University of Washington, Seattle Washington 1995
  • Residency:

    • University of Utah, Salt Lake City, Utah
  • Fellowship:

    • Pediatric endocrinology, Oregon Health & Science University, 1998-2001
  • Certifications:

    • American Academy of Pediatrics

Memberships and associations

  • Oregon State Medical Society


  • "Melanocortin-3 Receptors Expressed on Agouti-Related Peptide Neurons Inhibit Feeding Behavior in Female Mice." Obesity  In: , Vol. 26, No. 12, 01.12.2018, p. 1849-1855.
  • "A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors." Journal of Clinical Investigation  In: , Vol. 128, No. 5, 01.05.2018, p. 2025-2041.
  • "TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia." Brain, Behavior, and Immunity  In: , 01.01.2018.
  • "Increasing lean muscle mass in mice via nanoparticle-mediated hepatic delivery of follistatin mRNA." Theranostics  In: , Vol. 8, No. 19, 01.01.2018, p. 5276-5288.
  • "Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice." Journal of Neuroinflammation  In: , Vol. 14, No. 1, 219, 09.11.2017.
  • "Establishment and characterization of a novel murine model of pancreatic cancer cachexia." Journal of Cachexia, Sarcopenia and Muscle  In: , Vol. 8, No. 5, 01.10.2017, p. 824-838.
  • "Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells." Journal of Neuroinflammation  In: , Vol. 14, No. 1, 133, 01.07.2017.
  • "A life without hunger : The Ups (and downs) to modulating melanocortin-3 receptor signaling." Frontiers in Neuroscience  In: , Vol. 11, No. MAR, 128, 16.03.2017.
  • "Melanocortin-3 receptors expressed in Nkx2.1(+ve) neurons are sufficient for controlling appetitive responses to hypocaloric conditioning." Scientific Reports  In: , Vol. 7, 44444, 15.03.2017.
  • "Erratum : Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via Toll-like receptor engagement (The Journal of Biological Chemistry (2016) 291 (24607-24617) DOI: 10.1074/jbc.A116.745653)." Journal of Biological Chemistry  In: , Vol. 292, No. 8, 24.02.2017, p. 3541.
  • "Dexamethasone chemotherapy does not disrupt orexin signaling." PLoS One  In: , Vol. 11, No. 12, e0168731, 01.12.2016.
  • "Mesenchymal stromal cell-derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via toll-like receptor engagement." Journal of Biological Chemistry  In: , Vol. 291, No. 47, 18.11.2016, p. 24607-24617.
  • "Hypothalamic Dysfunction and Multiple Sclerosis : Implications for Fatigue and Weight Dysregulation." Current Neurology and Neuroscience Reports  In: , Vol. 16, No. 11, 98, 01.11.2016.
  • "A distinct brain pathway links viral RNA exposure to sickness behavior." Scientific Reports  In: , Vol. 6, 29885, 20.07.2016.
  • "Leukemia inhibitory factor as a mediator of lipopolysaccharide effects on appetite and selected hormones and metabolites." Journal of Animal Science  In: , Vol. 94, No. 7, 01.07.2016, p. 2789-2797.
  • "Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss." Molecular Metabolism  In: , 01.04.2016.
  • "Hypothalamic inflammation and food intake regulation during chronic illness." Peptides  In: , Vol. 77, 01.03.2016, p. 60-66.
  • "RHEB1 expression in embryonic and postnatal mouse." Histochemistry and Cell Biology  In: , 26.12.2015, p. 1-12.
  • "Defense of elevated body weight setpoint in Diet-Induced obese rats on low energy diet is mediated by loss of melanocortin sensitivity in the paraventricular hypothalamic nucleus." PLoS One  In: , Vol. 10, No. 10, e0139462, 07.10.2015.
  • "The central role of hypothalamic inflammation in the acute illness response and cachexia." Seminars in Cell and Developmental Biology  In: , 17.08.2015.
  • "Maternal high-fat diet and obesity compromise fetal hematopoiesis." Molecular Metabolism  In: , Vol. 4, No. 1, 01.01.2015, p. 25-38.
  • "Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice." Endocrinology  In: , Vol. 156, No. 1, 01.01.2015, p. 193-202.
  • "The regulation of muscle mass by endogenous glucocorticoids." Frontiers in Physiology  In: , Vol. 6, No. FEB, 12, 2015.
  • "Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity." Obesity  In: , Vol. 22, No. 10, 01.10.2014, p. 2109-2114.
  • "Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle." PLoS One  In: , Vol. 9, No. 9, e106489, 25.09.2014.
  • "Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke." PLoS One  In: , Vol. 9, No. 5, e97529, 13.05.2014.
  • "A role for orexin in cytotoxic chemotherapy-induced fatigue." Brain, Behavior, and Immunity  In: , Vol. 37, 03.2014, p. 84-94.
  • "Adipose tissue NK cells manifest an activated phenotype in human obesity." Metabolism: Clinical and Experimental  In: , Vol. 62, No. 11, 11.2013, p. 1557-1561.
  • "Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus." Journal of Cerebral Blood Flow and Metabolism  In: , Vol. 33, No. 10, 10.2013, p. 1650-1656.
  • "Missense mutation in mouse GALC mimics human gene defect and offers new insights into krabbe disease." Human Molecular Genetics  In: , Vol. 22, No. 17, ddt190, 09.2013, p. 3397-3414.

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