Photo of Daniel L. Marks, M.D., Ph.D.

Daniel L. Marks M.D., Ph.D.

    • Professor of Pediatrics School of Medicine
    • Senior Associate Dean for Research Office of the Dean School of Medicine
    • Director of Patient Resiliency Program Brenden-Colson Center for Pancreatic Care School of Medicine
    • Director, Papé Family Pediatric Research Institute
    • Neuroscience Graduate Program School of Medicine
    • Physiology and Pharmacology Graduate Program School of Medicine

Associate Director, OHSU M.D./Ph.D. Program
Ray Hickey Chair for Pediatric Research
M.D./Ph.D. Program, School of Medicine

Dr. Marks' special interests are weight regulation in children, particulary involuntary weight loss or poor growth in chronic dieseases (cachexia, failure to thrive). His clinical areas of interest are all aspects of pediatric endocrinology (including growth, puberty, thyroid, diabetes and adrenal disorders), pediatric obesity and failure to thrive.

Dr. Marks received both his medical degree and Ph.D. in 1995 from the University of Washington in Seattle. Dr. Marks completed his residency at the University of Utah, SLC in 1998, followed by a fellowship in pediatric endocrinology at Oregon Health & Science University in 2001. Dr. Marks is currently the Senior Associate Dean for Research in the School of Medicine, Associate Director of the OHSU MD, Ph.D. program, Director of the Patient Resiliency Program for the Brenden-Colson Center for Pancreatic Care and the Director of the Papé Family Pediatric Research Institute at Oregon Health & Science University in Portland, OR. Dr. Marks also served as a Consulting Senior Scientific Advisor for the Bill & Melinda Gates Foundation.

Areas of interest

  • patient resiliency
  • cachexia
  • failure to thrive
  • fatigue

Education

  • Ph.D., University of Washington School of Medicine, Seattle Washington 1993
  • M.D., University of Washington, Seattle Washington 1995
  • Residency:

    • University of Utah, Salt Lake City, Utah
  • Fellowship:

    • Pediatric endocrinology, Oregon Health & Science University, 1998-2001
  • Certifications:

    • American Academy of Pediatrics

Memberships and associations

  • Oregon State Medical Society

Publications

  • "Missense mutation in mouse GALC mimics human gene defect and offers new insights into krabbe disease" Human Molecular Genetics September 2013
  • "Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β" Journal of Neuroinflammation October 3 2012
  • "Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat" Nature Neuroscience  2001
  • "Hypothalamic mechanisms in cachexia" Physiology and Behavior July 2010
  • "Maternal high-fat diet and obesity compromise fetal hematopoiesis" Molecular Metabolism January 1 2015
  • "Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system" PLoS One July 27 2012
  • "Pancreatic inflammation and increased islet macrophages in insulin-resistant juvenile primates" Journal of Endocrinology May 2013
  • "Melanocortin pathway" Annales d'Endocrinologie  2002
  • "Cancer anorexia-cachexia syndrome" Current Opinion in Clinical Nutrition and Metabolic Care July 2004
  • "The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist" Endocrinology June 2005
  • "Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice" Metabolism: Clinical and Experimental August 2012
  • "Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells" Diabetologia June 2011
  • "Central role of the melanocortin-4 receptors in appetite regulation after endotoxin" Journal of Animal Science October 2008
  • "Ala67Thr Polymorphism in the Agouti-Related Peptide Gene Is Associated with Inherited Leanness in Humans" American Journal of Medical Genetics, Part A April 30 2004
  • "Therapy insight" Nature Reviews Endocrinology August 25 2006
  • "Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet" Endocrinology April 2010
  • "Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity" Obesity October 1 2014
  • "The central melanocortin system can directly regulate serum insulin levels" Endocrinology  2000
  • "Hypothalamic regulation of muscle metabolism" Current Opinion in Clinical Nutrition and Metabolic Care May 2011
  • "Cancer- and endotoxin-induced cachexia require intact glucocorticoid signaling in skeletal muscle" FASEB Journal September 2013
  • "Increased maternal fat consumption during pregnancy alters body composition in neonatal mice" American Journal of Physiology - Renal Fluid and Electrolyte Physiology December 2011
  • "Cachexia" Clinical Nutrition December 2008
  • "Cachexia" Trends in Endocrinology and Metabolism July 2006
  • "Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice" Journal of the American Society of Nephrology : JASN September 2007
  • "Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue" International Journal of Obesity September 2009
  • "Administration of IL-1β to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract" Peptides February 2009
  • "Neonatal estrogen exposure results in biphasic age-dependent effects on the skeletal development of male mice" Endocrinology January 1 2015
  • "Inhibition of steroid-induced galanin mRNA expression in GnRH neurons by specific NMDA-receptor blockade" Journal of Neuroendocrinology March 1996
  • "Organization of hindbrain segments in the zebrafish embryo" Neuron  1990
  • "Prostacyclin signaling regulates circulating ghrelin during acute inflammation" Journal of Endocrinology February 2008

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