Photo of Christopher L. Corless, M.D., Ph.D.

Christopher L. Corless M.D., Ph.D.

Dr. Corless oversees the development of novel molecular and proteomic tests for solid tumors. Further information can be found on the Corless research page.

Areas of interest

  • Role of oncogenic mutations in GI stromal tumors, melanomas, and other solid tumors
  • Development and application of new molecular diagnostic assays for use in research and clinical trials

Education

  • M.D., Ph.D., Washington University School of Medicine, St. Louis Missouri 1988
  • Residency:

    • Anatomic Pathology, Brigham & Women's Hospital, Boston, 1988-1990
  • Fellowship:

    • Urologic Pathology, Brigham & Women's Hospital, Boston, 1992-1993
    • Gastrointestinal Pathology, Brigham & Women's Hospital, Boston, 1990-1992
  • Certifications:

    • Anatomic Pathology (American Board of Pathology), 1993

Honors and awards

  • AOA

Memberships and associations

  • Am. Association for Cancer Research
  • Association for Molecular Pathology
  • Am. Society for Clinical Oncology

Publications

  • "Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis (desmoid tumor)" Journal of Clinical Oncology March 1 2006
  • "Primary extragastrointestinal stromal tumor of the pleura" American Journal of Surgical Pathology June 2010
  • "The square stent-based large vessel occluder" Journal of Vascular and Interventional Radiology  2000
  • "Association of multispecific CD4+ response to hepatitis C and severity of recurrence after liver transplantation" Gastroenterology  1999
  • "Gastrointestinal Stromal Tumors. Molecular Markers and Genetic Subtypes" Hematology/Oncology Clinics of North America October 2013
  • "BRAF in papillary thyroid carcinoma of ovary (struma ovarii)" American Journal of Surgical Pathology September 2007
  • "Hepatic iron overload" American Journal of Clinical Pathology  1998
  • "Distinctive morphology of renal cell carcinomas in tuberous sclerosis" International Journal of Surgical Pathology October 2010
  • "Dotlike or golgi-like KIT and PDGFRA staining in GISTs" American Journal of Surgical Pathology January 2009
  • "Accuracy of pathologic examination in detection of complete response after chemoradiation for esophageal cancer" American Journal of Surgery May 2007
  • "Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds" Proceedings of the National Academy of Sciences of the United States of America March 17 2009
  • "A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells" Proceedings of the National Academy of Sciences of the United States of America January 17 2006
  • "The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase" Proceedings of the National Academy of Sciences of the United States of America February 15 2006
  • "Imatinib in the management of multiple gastrointestinal stromal tumors associated with a germline KIT K642E mutation" Archives of Pathology and Laboratory Medicine September 2007
  • "Long-term results of adjuvant imatinib mesylate in localized, high-risk, primary gastrointestinal stromal tumor" Annals of Surgery September 2013
  • "Gastrointestinal stromal tumours" Canadian Journal of Gastroenterology and Hepatology March 2006
  • "KIT Mutations are Common in Testicular Seminomas" American Journal of Pathology January 2004
  • "Mitotic recombination as evidence of alternative pathogenesis of gastrointestinal stromal tumours in neurofibromatosis type 1." Journal of Medical Genetics January 2007
  • "Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells" Diabetologia June 2011
  • "Imatinib targeting of KIT-mutant oncoprotein in melanoma" Clinical Cancer Research December 1 2008
  • "Human pancreatic cancer fusion 2 (HPC2) 1-B3" Cancer cytopathology January 2013
  • "Crosstalk between KIT and FGFR3 promotes gastrointestinal stromal tumor cell growth and drug resistance" Journal of Cancer Research March 1 2015
  • "Percutaneous vein occlusion with small intestinal submucosa" CardioVascular and Interventional Radiology July 2007
  • "Pharmacoeconomic study of tacrolimus-based versus cyclosporine-based immunosuppressive therapy following liver transplantation" Transplantation Proceedings  2001
  • "In response" American Journal of Surgical Pathology August 2011
  • "Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours" Journal of Pathology January 2010
  • "Mutation profiling in gallbladder cancer in Indian population" Indian Journal of Pathology and Microbiology  2014
  • "TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies" American Journal of Surgical Pathology February 2007
  • "A nonrandom association of gastrointestinal stromal tumor (GIST) and desmoid tumor (deep fibromatosis)" Annals of Oncology May 2012
  • "Molecular Pathology"  March 2014

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