Over the years, Charles Springer, Ph.D., and co-workers have: introduced frequency shift reagents for the tissue 23Na magnetic resonance (MR), systematized tissue 23Na quadrupolar effects, systematized in vivoMR effects of bulk magnetic susceptibility (the bases of: fMRI, myocellular -1H2C- frequency splitting, most tissue 1H2O phase shifts, etc.), introduced relaxographic imaging (natural, unsupervised segmentation), and introduced the MR shutter-speed concept. The latter is a correction and generalization of the colloquially used "NMR time-scale" term. The shutter-speed has proven to be important in improving the mathematical modeling of MRI pharmacokinetics – especially of (Dynamic-Contrast-Enhanced) DCE-MRI data. An early success of shutter-speed DCE-MRI pharmacokinetic modeling has been the realization of breast cancer screening with essentially perfect specificity. This solves the very serious high false positive rate problem of mammographic screening. Also, shutter-speed corrections are usually necessary in order for DCE-MRI data to be used for accurate molecular imaging of water.
Dr. Springer received his B.S. and Ph.D. in chemistry from St. Louis University and the Ohio State University, respectively. He was a postdoctoral associate in the Aerospace Research Laboratory at the Wright‑Patterson Air Force Base in Ohio. He was a member of the Stony Brook Chemistry faculty for 35 years, and the Brookhaven National Laboratory Chemistry faculty for the last ten of those.
Dr. Springer served as director of the Advanced Imaging Research Center for six years, and is a member of the OHSU Physiology and Pharmacology and Biomedical Engineering faculties. Springer has held visiting faculty appointments at CalTech and Harvard Medical School. He has received the U.S. Air Force Research and Development Award, the Brookhaven National Laboratory Science and Technology Award, is a Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM), and chaired the In VivoMagnetic Resonance Gordon Research Conference. Dr. Springer has served on the ISMRM Board of Trustees and serves on the Editorial Boards of NMR in Biomedicine and Contrast Media and Molecular Imaging.Read more
Areas of interest
- Magnetic resonance spectroscopy
- MR shutter-speed
- In vivo magnetic resonance
- Ph.D., The Ohio State University 1972
- Postdoctoral associate at the Aerospace Research Laboratory, Wright-Patterson Air Force Base, Ohio
- "Fast, Na/K pump driven, steady-state transcytolemmal water exchange in neuronal tissue : A study of rat brain cortical cultures." Magnetic Resonance in Medicine In: , Vol. 79, No. 6, 01.06.2018, p. 3207-3217.
- "Using HO MR to measure and map sodium pump activity in vivo." Journal of Magnetic Resonance In: , 01.01.2018.
- "Brain active transmembrane water cycling measured by MR is associated with neuronal activity." Magnetic Resonance in Medicine In: , 01.01.2018.
- "Relative sensitivities of DCE-MRI pharmacokinetic parameters to arterial input function (AIF) scaling." Journal of Magnetic Resonance In: , Vol. 269, 01.08.2016, p. 104-112.
- "Toward 20 T magnetic resonance for human brain studies : opportunities for discovery and neuroscience rationale." Magnetic Resonance Materials in Physics, Biology and Medicine In: , 18.05.2016, p. 1-23.
- "Early prediction and evaluation of breast cancer response to neoadjuvant chemotherapy using quantitative DCE-MRI." Translational Oncology In: , Vol. 9, No. 1, 01.02.2016, p. 8-17.
- "Human whole blood HO transverse relaxation with gadolinium-based contrast reagents : Magnetic susceptibility and transmembrane water exchange." Magnetic Resonance in Medicine In: , 2016.
- "Synergistic antivascular and antitumor efficacy with combined cediranib and SC6889 in intracranial mouse glioma." PLoS One In: , Vol. 10, No. 12, 0144488, 01.12.2015.
- "Erratum : Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields (Magnetic Resonance in Medicine (2014) 71 (375-387))." Magnetic Resonance in Medicine In: , Vol. 74, No. 5, 01.11.2015, p. 1503.
- "Mapping human brain capillary water lifetime : High-resolution metabolic neuroimaging." NMR in Biomedicine In: , Vol. 28, No. 6, 01.06.2015, p. 607-623.
- "Human whole-blood HO longitudinal relaxation with normal and high-relaxivity contrast reagents : Influence of trans-cell-membrane water exchange." Magnetic Resonance in Medicine In: , Vol. 72, No. 6, 01.12.2014, p. 1746-1754.
- "Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields." Magnetic Resonance in Medicine In: , Vol. 71, No. 1, 01.2014, p. 375-387.
- "Intratumor mapping of intracellular water lifetime : Metabolic images of breast cancer?" NMR in Biomedicine In: , Vol. 27, No. 7, 2014, p. 760-773.
- "Feasibility of shutter-speed DCE-MRI for improved prostate cancer detection." Magnetic Resonance in Medicine In: , Vol. 69, No. 1, 01.2013, p. 171-178.
- "Cell membrane water exchange effects in prostate DCE-MRI." Journal of Magnetic Resonance In: , Vol. 218, 05.2012, p. 77-85.
- "Active trans-plasma membrane water cycling in yeast is revealed by NMR." Biophysical Journal In: , Vol. 101, No. 11, 07.12.2011, p. 2833-2842.
- "Discrimination of benign and malignant breast lesions by using shutter-speed dynamic contrast-enhanced MR imaging 1." Radiology In: , Vol. 261, No. 2, 11.2011, p. 394-403.
- "Dynamic-contrast-enhanced-MRI with extravasating contrast reagent : Rat cerebral glioma blood volume determination." Journal of Magnetic Resonance In: , Vol. 206, No. 2, 10.2010, p. 190-199.
- "Discrimination of intra- and extracellular 23Na+ signals in yeast cell suspensions using longitudinal magnetic resonance relaxography." Journal of Magnetic Resonance In: , Vol. 205, No. 1, 07.2010, p. 28-37.
- "Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents." Magnetic Resonance in Medicine In: , Vol. 61, No. 5, 05.2009, p. 1049-1058.
- "First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent : Evidence for human myocardial capillary recruitment in adenosine-induced hyperemia." NMR in Biomedicine In: , Vol. 22, No. 2, 2009, p. 148-157.
- "The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 105, No. 46, 18.11.2008, p. 17943-17948.
- "Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI." Proceedings of the National Academy of Sciences of the United States of America In: , Vol. 105, No. 46, 18.11.2008, p. 17937-17942.
- "The evaluation of esophageal adenocarcinoma using dynamic contrast-enhanced magnetic resonance imaging." Journal of Gastrointestinal Surgery In: , Vol. 12, No. 1, 01.2008, p. 166-175.
- "Na+/Ca2+-exchanger-mediated Mn2+-enhanced 1H2O MRI in hypoxic, perfused rat myocardium." Contrast Media and Molecular Imaging In: , Vol. 2, No. 5, 09.2007, p. 248-257.
- "Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo." Magnetic Resonance in Medicine In: , Vol. 57, No. 2, 02.2007, p. 308-318.
- "T MRI contrast in the human brain : Modulation of the longitudinal rotating frame relaxation shutter-speed during an adiabatic RF pulse." Journal of Magnetic Resonance In: , Vol. 181, No. 1, 07.2006, p. 135-147.
- "A unified magnetic resonance imaging pharmacokinetic theory : Intravascular and extracellular contrast reagents." Magnetic Resonance in Medicine In: , Vol. 54, No. 6, 12.2005, p. 1351-1359.
- "Pharmaco-thermodynamics of deuterium-induced oedema in living rat brain via 1H2O MRI : Implications for boron neutron capture therapy of malignant brain tumours." Physics in Medicine and Biology In: , Vol. 50, No. 9, 07.05.2005, p. 2127-2139.
- "Evidence for shutter-speed variation in CR bolus-tracking studies of human pathology." NMR in Biomedicine In: , Vol. 18, No. 3, 05.2005, p. 173-185.