Photo of Charles S. Springer, Jr., Ph.D.

Charles S. Springer Jr., Ph.D.

  • Portland Campus

    • Professor Advanced Imaging Research Center
    • Physiology and Pharmacology Graduate Program School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine

Over the years, Charles Springer, Ph.D., and co-workers have: introduced frequency shift reagents for the tissue 23Na magnetic resonance (MR), systematized tissue 23Na quadrupolar effects, systematized in vivoMR effects of bulk magnetic susceptibility (the bases of: fMRI, myocellular -1H2C- frequency splitting, most tissue 1H2O phase shifts, etc.), introduced relaxographic imaging (natural, unsupervised segmentation), and introduced the MR shutter-speed concept. The latter is a correction and generalization of the colloquially used "NMR time-scale" term. The shutter-speed has proven to be important in improving the mathematical modeling of MRI pharmacokinetics – especially of (Dynamic-Contrast-Enhanced) DCE-MRI data. An early success of shutter-speed DCE-MRI pharmacokinetic modeling has been the realization of breast cancer screening with essentially perfect specificity. This solves the very serious high false positive rate problem of mammographic screening. Also, shutter-speed corrections are usually necessary in order for DCE-MRI data to be used for accurate molecular imaging of water. 

Dr. Springer received his B.S. and Ph.D. in chemistry from St. Louis University and the Ohio State University, respectively. He was a postdoctoral associate in the Aerospace Research Laboratory at the Wright‑Patterson Air Force Base in Ohio. He was a member of the Stony Brook Chemistry faculty for 35 years, and the Brookhaven National Laboratory Chemistry faculty for the last ten of those. 

Dr. Springer served as director of the Advanced Imaging Research Center for six years, and is a member of the OHSU Physiology and Pharmacology and Biomedical Engineering faculties. Springer has held visiting faculty appointments at CalTech and Harvard Medical School. He has received the U.S. Air Force Research and Development Award, the Brookhaven National Laboratory Science and Technology Award, is a Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM), and chaired the In VivoMagnetic Resonance Gordon Research Conference. Dr. Springer has served on the ISMRM Board of Trustees and serves on the Editorial Boards of NMR in Biomedicine and Contrast Media and Molecular Imaging.

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Areas of interest

  • Magnetic resonance spectroscopy
  • MR shutter-speed
  • DCE-MRI
  • Neuroscience
  • Pharmacokinetics
  • In vivo magnetic resonance

Education

  • Ph.D., The Ohio State University 1972
  • Fellowship:

    • Postdoctoral associate at the Aerospace Research Laboratory, Wright-Patterson Air Force Base, Ohio

Publications

  • "Bulk magnetic susceptibility shifts in NMR studies of compartmentalized samples" Magnetic Resonance in Medicine  1990
  • "Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields" Magnetic Resonance in Medicine January 2014
  • "Dynamic-contrast-enhanced-MRI with extravasating contrast reagent" Journal of Magnetic Resonance October 2010
  • "Magnetic Resonance Imaging (MRI) detection of the marine brain response to light" Proceedings of the National Academy of Sciences of the United States of America June 11 1996
  • "First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent" NMR in Biomedicine  2009
  • "The intrinsic structural asymmetry of highly curved phospholipid bilayer membranes" Biochimica et Biophysica Acta - Biomembranes October 17 1977
  • "Erratum" Magnetic Resonance in Medicine  2002
  • "Equilibrium water exchange between the intra- and extracellular spaces of mammalian brain" Magnetic Resonance in Medicine September 1 2003
  • "Discrimination of intra- and extracellular 23Na+ signals in yeast cell suspensions using longitudinal magnetic resonance relaxography" Journal of Magnetic Resonance July 2010
  • "Chiral chelates with chiral ligands. The stereoisomers of tris [(+)-3-acetylcamphorato]cobalt(III)" Inorganic Chemistry  1971
  • "A unified magnetic resonance imaging pharmacokinetic theory" Magnetic Resonance in Medicine December 2005
  • "The molecular environment of intracellular sodium" NMR in Biomedicine October 1991
  • "Measurement of metal cation compartmentalization in tissue by high-resolution metal cation NMR." Annual Review of Biophysics  1987
  • "Aqueous shift reagents for high-resolution cationic nuclear magnetic resonance. 2. 25Mg, 39K, and 23Na resonances shifted by chelidamate complexes of dysprosium(III) and thulium(III)" Inorganic Chemistry  1983
  • "Lifetimes of complexes of the antibiotic x-537a (lasalocid a) with physiological cations in methanol. Determination by NMR using a dissociative shift reagent" Biophysical Chemistry  1978
  • "Aqueous shift reagents for high-resolution cationic nuclear magnetic resonance. III. Dy(TTHA)3-, Tm(TTHA)3-, and Tm(PPP)2 7- " Journal of Magnetic Resonance (1969)  1984
  • " 25Mg NMR Studies of magnesium binding to erythrocyte constituents" Journal of Inorganic Biochemistry November 1 1991
  • "High-resolution NMR studies of transmembrane cation transport" Proceedings of the National Academy of Sciences of the United States of America  1982
  • "Mapping human brain capillary water lifetime" NMR in Biomedicine June 1 2015
  • "Aqueous shift reagents for high-resolution cation NMR. VI. Titration curves for in vivo 23Na and 1H2O MRS obtained from rat blood." NMR in Biomedicine January 1993
  • "High-resolution 23Na-NMR studies of human erythrocytes" American Journal of Physiology - Renal Fluid and Electrolyte Physiology May 1984
  • "Magnetic susceptibility shift selected imaging (MESSI) and localized 1H2O spectroscopy in living plant tissues" NMR in Biomedicine  2000
  • "Effects of equilibrium exchange on diffusion-weighted NMR signals" Magnetic Resonance in Medicine March 1 2003
  • "Nuclear magnetic resonance assessment of adenosine triphosphate (Atp) dynamics in ischemic mouse livers perfused with adenine and ribose" Investigative Radiology  1987
  • "Abnormal brain activation to visual stimulation in cocaine abusers" Life Sciences August 29 2003
  • "Variation of the Relaxographic "Shutter-Speed" for Transcytolemmal Water Exchange Affects the CR Bolus-Tracking Curve Shape" Magnetic Resonance in Medicine December 2003
  • "Direct measurement of enantiomerization of labile aluminium(III) β-diketonates" Chemical Communications  1971
  • "T1Ï� MRI contrast in the human brain" Journal of Magnetic Resonance July 2006
  • "VOLUME PROFILES OF CHEMICAL REACTIONS."   1982
  • "The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo" Proceedings of the National Academy of Sciences of the United States of America November 18 2008

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