Photo of Charles Roselli, Ph.D.

Charles Roselli Ph.D.

  •      (503) 494-5837
    • Professor of Physiology and Pharmacology School of Medicine
    • Graduate Program in Biomedical Sciences School of Medicine

Research in my lab concerns the actions of sex hormones in the brain. In mammals, brain tissue, particularly that which is involved in neuroendocrine function and reproductive behavior, contains high levels of cytochrome P450 aromatase. This enzyme converts circulating testosterone into estradiol. Although estradiol is generally considered a female hormone, aromatization seems to constitute a complementary signal pathway for androgen action in certain brain tissues. Estrogens are known to exert profound feedback effects on the brain that regulate reproduction and, more generally, are able to induce synaptic connections and protect neurons from injury. Locally-synthesized estradiol appears to play a role in male physiology that augments effects exerted by circulating testosterone.  Our current research uses sheep to address the question of how testosterone acts during development to organize male-typical features of brain morphology and neurochemistry to produce associated sex-differences in reproductive behaviors.   Sex differences in brain development are important to understand because they underlie robust neurological differences between healthy males and females and contribute to sex biases in the incidence of certain brain diseases and psychiatric conditions.

Publications

  • "Age-dependent effects of testosterone in experimental stroke" Journal of Cerebral Blood Flow and Metabolism  2009
  • "Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system" Endocrinology  1985
  • "Prenatal exposure to vinclozolin disrupts selective aspects of the gonadotrophin-releasing hormone neuronal system of the rabbit" Journal of Neuroendocrinology  2010
  • "The quantitative distribution of cytosolic androgen receptors in microdissected areas of the male rat brain" Endocrinology  1987
  • "Cell death in the central division of the medial preoptic nucleus of male and female lamb fetuses" Brain Research March 20 2014
  • "Distribution of aromatase cytochrome P450 messenger ribonucleic acid in adult rhesus monkey brains" Biology of Reproduction October 1997
  • "Review" Domestic Animal Endocrinology January 2000
  • "Estradiol increases the duration of nuclear androgen receptor occupation in the preoptic area of the male rat treated with dihydrotestosterone" Journal of Steroid Biochemistry and Molecular Biology  1992
  • "Sex differences in androgen-regulated cytochrome P450 aromatase mRNA in the rat brain" Endocrine August 1996
  • "Androgens regulate brain aromatase activity in adult male rats through a receptor mechanism" Endocrinology  1984
  • "Testosterone regulates aromatase activity in discrete brain areas of male rhesus macaques" Biology of Reproduction  1989
  • "Sexual differentiation of sexual behavior and its orientation" Frontiers in Neuroendocrinology April 2011
  • "Cytochrome p450 aromatase in testis and epididymis of male rhesus monkeys" Endocrine  2001
  • "Expression of steroid hormone receptors in the fetal sheep brain during the critical period for sexual differentiation" Brain Research September 19 2006
  • "Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity" Alcohol December 2011
  • "Distribution of aromatase activity in brain and peripheral tissues of male sheep" Reproduction, Fertility and Development  2004
  • "Neonatal testosterone exposure protects adult male rats from stroke" Neuroendocrinology April 2013
  • "The Volume of a Sexually Dimorphic Nucleus in the Ovine Medial Preoptic Area/Anterior Hypothalamus Varies with Sexual Partner Preference" Endocrinology February 2004
  • "Cytochrome P450 aromatase (CYP19) in the non-human primate brain" Journal of Steroid Biochemistry and Molecular Biology  2001
  • "Time-course and steroid specificity of aromatase induction in rat hypothalamus-preoptic area." Biology of Reproduction October 1987
  • "Regulation of hypothalamic luteinizing hormone-releasing hormone levels by testosterone and estradiol in male rhesus monkeys" Brain Research February 19 1990
  • "Hormonal influences on sexual partner preference in rams" Archives of Sexual Behavior February 2002
  • "Expression of the orphan receptor steroidogenic factor-1 mRNA in the rat medial basal hypothalamus" Brain Research February 1997
  • "Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity" International Journal of Oncology  2009
  • "Endocrine correlates of partner preference behavior in rams" Biology of Reproduction July 1996
  • "Estrogen, Testosterone, and Sequential Movement in Men" Behavioral Neuroscience October 2008
  • "Anatomic relationships between aromatase and androgen receptor mRNA expression in the hypothalamus and amygdala of adult male cynomolgus monkeys" Journal of Comparative Neurology October 15 2001
  • "Sexual behaviour of rams" Journal of reproduction and fertility. Supplement  1999
  • "Prolactin expression in the sheep brain" Neuroendocrinology May 2008
  • "The role of pregnane neurosteroids in ethanol withdrawal" Pharmacology and Therapeutics February 2004

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