Photo of Brett C. Sheppard, M.D.

Brett C. Sheppard M.D.

Dr. Sheppard focuses on surgery for diseases of the pancreas. He has a special interest in caring for patients with pancreatic cancer. In addition, Dr. Sheppard does surgery for other diseases of the pancreas and adrenal gland, and for stomach and esophagus disorders. Whenever possible, Dr. Sheppard uses his skill and knowledge in minimally invasive surgery to help patients recover more quickly and with less discomfort after surgery. Dr. Sheppard is deeply committed to keeping patients safe and to enhancing the quality of surgical care. He belongs to groups working to improve the quality of surgical care both at OHSU and in the state of Oregon. Dr. Sheppard's research interests are focused on giving patients with pancreatic cancer better results from treatment by earlier diagnosis and improved therapy. He also studies how to improve the results of gastrointestinal (digestive system) surgery, including surgeries that involve the endocrine (hormone) system, and how to make the best use of minimally invasive surgery techniques. Dr. Sheppard is a member of the OHSU Knight Cancer Institute. He is also the surgical principal investigator for OHSU of the American College of Surgeons Oncology Group and a member of the Southwest Oncology Group, which offers patients the latest in cancer care through clinical trials. In addition, he belongs to national and international scientific societies dedicated to improving patient care in both traditional (open) and minimally invasive gastrointestinal surgery.


  • M.D., University of Health Sciences, The Chicago Medical School, Chicago Illinois 1984
  • Residency:

    • General Surgery, Oregon Health & Science University, Portland, OR, 1984-87, 1989-91
  • Fellowship:

    • Surgical Oncology, National Institutes of Health/National Cancer Institute, Bethesda, MD, 1987-89
  • Certifications:

    • American Board of Surgery, 1992, recertification, 2010

Memberships and associations

  • Alliance for Clinical Trials in Oncology


  • "Lymphoplasmacytic sclerosing pancreatitis presenting as a pancreatic head mass in a child" Journal of Pediatric Surgery May 2006
  • "Biologic prosthesis to prevent recurrence after laparoscopic paraesophageal hernia repair" Journal of the American College of Surgeons October 2011
  • "Improved quality of life after bilateral laparoscopic adrenalectomy for Cushing's disease [6]" Annals of Surgery May 2008
  • "Lymph Node Harvest During Esophagectomy Is Not Influenced by Use of Neoadjuvant Therapy or Clinical Disease Stage" Journal of Gastrointestinal Surgery April 25 2015
  • "The laparoscopic sponge" Surgical Endoscopy and Other Interventional Techniques August 1 2003
  • "Transition from open to laparoscopic adrenalectomy" Surgical Endoscopy and Other Interventional Techniques October 2003
  • "The international normalized ratio overestimates coagulopathy in patients after major hepatectomy" American Journal of Surgery  2014
  • "Transition from open to laparoscopic fundoplication" JAMA Surgery March 1999
  • "New approaches to the minimauy invasive treatment of pancreatic cancer" Cancer Journal (United States)  1998
  • "Demographic and socioeconomic trends in the use of laparoscopic appendectomy from 1997 to 2003" American Journal of Surgery May 2008
  • "Tumor necrosis factor and interleukin-1 protection against the lethal effects of tumor necrosis factor" Surgery (United States)  1991
  • "Gastrectomy for complications of bariatric procedures" Obesity Surgery  1996
  • "Diagnosis and management of blunt pancreatic ductal injury in the era of high-resolution computed axial tomography" American Journal of Surgery May 2007
  • "Comparison of transgastric NOTES and laparoscopic peritoneoscopy for detection of peritoneal metastases" Annals of Surgery August 2009
  • "Impact of tolerance on antitumor efficacy of tumor necrosis factor in mice" Journal of Cancer Research April 15 1990
  • "Evaluation of Endoscopic Full-Thickness Plication on Anti-Reflux Valve Competency" Journal of Surgical Education March 2008
  • "Significant understaging is seen in clinically staged T2N0 esophageal cancer patients undergoing esophagectomy" Diseases of the Esophagus  2015
  • "Prevention of percutaneous endoscopic gastrostomy stoma metastases in patients with active oropharyngeal malignancy." Surgical Endoscopy and Other Interventional Techniques October 2003
  • "Impact of comorbidity on outcomes and overall survival after open and minimally invasive esophagectomy for locally advanced esophageal cancer" Surgical Endoscopy and Other Interventional Techniques November 2013
  • "Human pancreatic cancer fusion 2 (HPC2) 1-B3" Cancer cytopathology January 2013
  • "Brunner's gland hamartoma" Canadian Journal of Gastroenterology and Hepatology  2002
  • "Erratum" American Journal of Surgery June 2011
  • "Bile duct injury after laparoscopic cholecystectomy in hospitals with and without surgical residency programs" Surgical Endoscopy and Other Interventional Techniques June 2011
  • "Comparison of outcomes of open versus laparoscopic Nissen fundoplication performed in a single practice" American Journal of Surgery  1998
  • "Improved quality of life after bilateral laparoscopic adrenalectomy for cushing's disease" Annals of Surgery May 2007
  • "Total peroral intraoperative enteroscopy for obscure GI bleeding using a dedicated push enteroscope" Gastrointestinal Endoscopy  1998
  • "A suitable animal model for laparoscopic hepatic resection training" Surgical Endoscopy and Other Interventional Techniques October 2007
  • "Management of islet cell tumors in patients with multiple endocrine neoplasia" Surgery (United States)  1989
  • "Surgical complications of bone marrow transplantation" American Journal of Surgery May 1 2003
  • "Patient and Peri-operative Predictors of Morbidity and Mortality After Esophagectomy" Journal of Gastrointestinal Surgery  2010

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