Photo of Brett C. Sheppard, M.D., F.A.C.S.

Brett C. Sheppard M.D., F.A.C.S.

  • (503) 494-4373
    • Professor of Surgery, Division of Gastrointestinal and General Surgery School of Medicine
    • William E. Colson Chair of Pancreatic Disease Research Surgery School of Medicine
    • Vice Chair for Clinical Affairs and Quality Surgery School of Medicine

Dr. Brett Sheppard is a professor of surgery and vice chair for clinical affairs and quality in the Division of Gastrointestinal and General Surgery in the OHSU School of Medicine. He is also co-director of OHSU's Brenden-Colson Center for Pancreatic Care.

Dr. Sheppard is one of the world's leading [TM1] experts on surgery for diseases of the pancreas, especially pancreatic cancer. He also performs surgery for other diseases of the pancreas and adrenal gland, and for disorders of the stomach and esophagus. When minimally invasive surgery is possible, Dr. Sheppard uses his skills and knowledge in the procedures to help patients recover more quickly and with less discomfort.

Dr. Sheppard is deeply committed to keeping patients safe and to enhancing the quality of surgical care. His passion is learning more through research to help doctors detect pancreatic cancer earlier. Finding cancer earlier will significantly improve patient results from cancer treatment. He also performs research on improving the results of gastrointestinal (digestive system) surgery, and on how to make the best use of minimally invasive surgery techniques.

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  • M.D., University of Health Sciences, The Chicago Medical School, Chicago Illinois 1984
  • Residency:

    • General Surgery, Oregon Health & Science University, Portland, OR, 1984-87, 1989-91
  • Fellowship:

    • Surgical Oncology, National Institutes of Health/National Cancer Institute, Bethesda, MD, 1987-89
  • Certifications:

    • American Board of Surgery, 1992, recertification, 2010

Memberships and associations

  • Alliance for Clinical Trials in Oncology
  • American Association of Endocrine Surgeons
  • American College of Gastroenterology
  • American College of Surgeons-Fellow
  • American College of Surgeons Oncology Group (ACOSOG)
  • American Gastroenterological Association (AGA)
  • American Hepato Pancreato Biliary Association (AHPBA)
  • American Pancreas Association (APA)
  • American Surgical Association (ASA)
  • MIS Fellowship Council
  • North Pacific Surgical Association
  • Pacific Coast Surgical Association
  • Society of American Gastrointestinal Endoscopic Surgeons (SAGES)
  • Society for Surgery of the Alimentary Tract (SSAT)
  • Society of Surgical Oncology (SSO)
  • Southwest Oncology Group (SWOG)
  • Surgical Outcomes Club (SOC)
  • Western Surgical Association
  • The Mackenzie Alumni Society
  • Multnomah County Medical Society
  • Portland Surgical Society
  • Oregon Medical Association
  • Oregon Chapter-American College of Surgeons


  • "Lymphoplasmacytic sclerosing pancreatitis presenting as a pancreatic head mass in a child" Journal of Pediatric Surgery May 2006
  • "Biologic prosthesis to prevent recurrence after laparoscopic paraesophageal hernia repair" Journal of the American College of Surgeons October 2011
  • "Improved quality of life after bilateral laparoscopic adrenalectomy for Cushing's disease [6]" Annals of Surgery May 2008
  • "Lymph Node Harvest During Esophagectomy Is Not Influenced by Use of Neoadjuvant Therapy or Clinical Disease Stage" Journal of Gastrointestinal Surgery April 25 2015
  • "The laparoscopic sponge" Surgical Endoscopy and Other Interventional Techniques August 1 2003
  • "Transition from open to laparoscopic adrenalectomy" Surgical Endoscopy and Other Interventional Techniques October 2003
  • "The international normalized ratio overestimates coagulopathy in patients after major hepatectomy" American Journal of Surgery  2014
  • "Transition from open to laparoscopic fundoplication" JAMA Surgery March 1999
  • "New approaches to the minimauy invasive treatment of pancreatic cancer" Cancer journal (Sudbury, Mass.)  1998
  • "Demographic and socioeconomic trends in the use of laparoscopic appendectomy from 1997 to 2003" American Journal of Surgery May 2008
  • "Tumor necrosis factor and interleukin-1 protection against the lethal effects of tumor necrosis factor" Surgery (United States)  1991
  • "Gastrectomy for complications of bariatric procedures" Obesity Surgery  1996
  • "Diagnosis and management of blunt pancreatic ductal injury in the era of high-resolution computed axial tomography" American Journal of Surgery May 2007
  • "Comparison of transgastric NOTES and laparoscopic peritoneoscopy for detection of peritoneal metastases" Annals of Surgery August 2009
  • "Impact of tolerance on antitumor efficacy of tumor necrosis factor in mice" Journal of Cancer Research April 15 1990
  • "Evaluation of Endoscopic Full-Thickness Plication on Anti-Reflux Valve Competency" Journal of Surgical Education March 2008
  • "Significant understaging is seen in clinically staged T2N0 esophageal cancer patients undergoing esophagectomy" Diseases of the Esophagus  2015
  • "Prevention of percutaneous endoscopic gastrostomy stoma metastases in patients with active oropharyngeal malignancy." Surgical Endoscopy and Other Interventional Techniques October 2003
  • "Impact of comorbidity on outcomes and overall survival after open and minimally invasive esophagectomy for locally advanced esophageal cancer" Surgical Endoscopy and Other Interventional Techniques November 2013
  • "Human pancreatic cancer fusion 2 (HPC2) 1-B3" Cancer cytopathology January 2013
  • "Brunner's gland hamartoma" Canadian Journal of Gastroenterology and Hepatology  2002
  • "Erratum" American Journal of Surgery June 2011
  • "Bile duct injury after laparoscopic cholecystectomy in hospitals with and without surgical residency programs" Surgical Endoscopy and Other Interventional Techniques June 2011
  • "Comparison of outcomes of open versus laparoscopic Nissen fundoplication performed in a single practice" American Journal of Surgery  1998
  • "Improved quality of life after bilateral laparoscopic adrenalectomy for cushing's disease" Annals of Surgery May 2007
  • "Total peroral intraoperative enteroscopy for obscure GI bleeding using a dedicated push enteroscope" Gastrointestinal Endoscopy  1998
  • "A suitable animal model for laparoscopic hepatic resection training" Surgical Endoscopy and Other Interventional Techniques October 2007
  • "Management of islet cell tumors in patients with multiple endocrine neoplasia" Surgery (United States)  1989
  • "Surgical complications of bone marrow transplantation" American Journal of Surgery May 1 2003
  • "Patient and Peri-operative Predictors of Morbidity and Mortality After Esophagectomy" Journal of Gastrointestinal Surgery  2010

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