Dr. Adam Krieg is an Assistant Professor of Obstetrics and Gynecology in the division of Gynecologic Oncology. He holds an adjunct appointment with the Oregon National Primate Research Center in the Division of Reproductive and Developmental Sciences.
Dr. Krieg’s research team studies the role of reduced tissue oxygen (hypoxia) as a factor in tumor progression and normal physiological processes. Dr. Krieg is investigating how various hypoxia-regulated genes contribute to therapeutic response and resistance in gynecological cancers, especially high-grade serous ovarian carcinoma, the most common and deadly of ovarian cancers. Many hypoxia-regulated genes, such as the class of epigenetic regulators called histone demethylases, are also highly expressed in normal reproductive tissues and may contribute to human fertility. To that end, Dr. Krieg is also investigating the role of oxygen, hypoxia-regulated genes, and histone demethylases in influencing normal ovarian processes and infertility.
Dr. Krieg received his Ph.D. in Biochemistry from the University of Illinois, Urbana-Champaign in 2003. As a postdoctoral fellow in the department of Radiation Oncology at Stanford University, he conducted research in hypoxic gene expression mechanisms. In 2010, he continued his studies as an assistant professor of OB/GYN at the University of Kansas Medical Center. He joined the faculty of Obstetrics and Gynecology at OHSU as an assistant professor in 2016.Read more
Areas of interest
- Tumor hypoxia
- Low oxygen biology
- Ovarian and Gynecological Cancers
- Reproductive physiology
- B.S., Oregon State University, Corvallis Oregon 1995
- Ph.D., University of Illinois, Urbana-Champaign, Urbana Illinois 2003
- Postdoctoral Fellow, Radiation and Cancer Biology, Stanford University. 2003-2010
Honors and awards
- Junior Investigator. NIH/Kansas COBRE Molecular Regulation of Cell Development and Differentiation (2010-2013)
- Ruth L. Kirchstein NIH National Research Service Award (2008-2010)
- University of Illinois NIH Reproductive Biology Predoctoral Training Grant (1998–2000)
- University of Illinois NIH Cell and Molecular Biology Predoctoral Training Grant (1995–1998)
- Oregon State University Jesse Hanson College of Science Scholarship (1992–1995)
- Oregon State University Presidential Scholarship (1991–1995)
- Molalla, OR Rotary Scholarship (1991–1995)
Licofelone enhances the efficacy of paclitaxel in ovarian cancer by reversing drug resistance and tumor stem-like properties. Hirst J, Pathak HB, Hyter S, Pessetto ZY, Ly T, Graw S, Koestler DC, Krieg AJ, Roby KF, Godwin AK. Cancer Res. 2018 Jun 11. pii: canres.3993.2017. doi: 10.1158/0008-5472.CAN-17-3993. [Epub ahead of print]. PMID: 29891506.
Histone demethylase KDM4A and KDM4B expression in granulosa cells from women undergoing in vitro fertilization. Krieg AJ, Mullinax SR, Grimstad F, Marquis K, Constance E, Hong Y, Krieg SA, Roby KF. J Assist Reprod Genet. 2018 Jun;35(6):993-1003. doi: 10.1007/s10815-018-1151-3. Epub 2018 Mar 14. PMID: 29536385.
KDM4A regulates HIF-1 levels through H3K9me3. Dobrynin G, McAllister TE, Leszczynska KB, Ramachandran S, Krieg AJ, Kawamura A, Hammond EM. Sci Rep. 2017 Sep 11;7(1):11094. doi: 10.1038/s41598-017-11658-3. PMID: 28894274.
Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. Padró M, Louie RJ, Lananna BV, Krieg AJ, Timmerman LA, Chan DA. BMC Cancer. 2017 Mar 20;17(1):203. doi: 10.1186/s12885-017-3140-9. PMID: 28320353.
KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ. Nucleic Acids Res. 2017 Apr 20;45(7):3674-3692. doi: 10.1093/nar/gkw1281. PMID: 28073943.
The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer. Wilson C, Qiu L, Hong Y, Karnik T, Tadros G, Mau B, Ma T, Mu Y, New J, Louie RJ, Gunewardena S, Godwin AK, Tawfik OW, Chien J, Roby KF, Krieg AJ. Oncogene. 2017 May 4;36(18):2565-2576. doi: 10.1038/onc.2016.412. Epub 2016 Nov 21. PMID: 27869162.
HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MA, Mason CW, Krieg AJ, Soares MJ. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7212-E7221. Epub 2016 Nov 2. PMID: 27807143.
Epigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor Hypoxia. Ramachandran S, Ient J, Göttgens EL, Krieg AJ, Hammond EM. Genes (Basel). 2015 Sep 25;6(4):935-56. doi: 10.3390/genes6040935. Review. PMID: 26426056.
Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells. Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4441-6. doi: 10.1073/pnas.1418164112. Epub 2015 Mar 19. PMID: 25792458.
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13373-8. doi: 10.1073/pnas.1404848111. Epub 2014 Sep 3. PMID: 25187556.