Caren Weinhouse Lab

 Caren Weinhouse Ph.D.
Caren Weinhouse Ph.D.

Research interests

I study the mechanisms by which environmental cues, like chemical pollutants, induce changes in epigenetic marks, which control gene expression patterns. I focus on pollutant specificity, life-course persistence, and population variability in these responses. My goal is to translate basic science findings in cell culture and mice to human population settings, or “bench to community.”

Publications

  • Weinhouse C, Truong L, Meyer JN, Allard P. Caenorhabditis elegans as an emerging model system in environmental epigenetics.  Environ Mol Mutagen. 2018 Aug;59(7):560-575. Review.
  • Weinhouse C, Ortiz EJ, Berky AJ, Bullins P, Hare-Grogg J, Rogers L, Morales AM, Hsu-Kim H, Pan WK. Hair Mercury Level is Associated with Anemia and Micronutrient Status in Children Living Near Artisanal and Small-Scale Gold Mining in the Peruvian Amazon. Am J Trop Med Hyg. 2017 Dec;97(6):1886-1897.
  • Weinhouse C. Mitochondrial-epigenetic crosstalk in environmental toxicology. Toxicology. 2017 Nov 1;391:5-17. Review.
  • Anderson OS, Kim JH, Peterson KE, Sanchez BN, Sant KE, Sartor MA, Weinhouse C, Dolinoy DC. Novel Epigenetic Biomarkers Mediating Bisphenol A Exposure and Metabolic Phenotypes in Female Mice.  Endocrinology. 2017 Jan 1;158(1):31-40.
  • Weinhouse C, Sartor MA, Faulk C, Anderson OS, Sant KE, Harris C, Dolinoy DC. Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A.  Environ Mol Mutagen. 2016 Jul;57(6):435-46. 
  • Weinhouse C, Bergin IL, Harris C, Dolinoy DC. Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health.  Epigenetics. 2015;10(12):1099-110.
  • Weinhouse C, Anderson OS, Bergin IL, Vandenbergh DJ, Gyekis JP, Dingman MA, Yang J, Dolinoy DC. Dose-dependent incidence of hepatic tumors in adult mice following perinatal exposure to bisphenol A.  Environ Health Perspect. 2014 May;122(5):485-91.
  • Bernal AJ, Dolinoy DC, Huang D, Skaar DA, Weinhouse C, Jirtle RL. Adaptive radiation induced epigenetic alterations mitigated by antioxidants. FASEB J. 2013; 27(2): 665-71.
  • Weinhouse C, Anderson OS, Jones TR, Kim J, Liberman SA, Nahar MS, Rozek LS, Jirtle RL, Dolinoy DC. An expression microarray approach for the identification of metastable epialleles in the mouse genome. Epigenetics. 2011; 6(9): 1105-1113.
  • Dolinoy DC, Weinhouse C, Jones TR, Rozek LS, Jirtle RL. Variable histone modifications at the Avy metastable epiallele. Epigenetics. 2010; 5(7): 637-44.