Congratulations to Drs. Jayne Manigrasso and Brandon Togioka for the selection of their abstract for moderated poster presentation entitled: “Ruling out an epidural arteriovenous malformation in a parturient with Hereditary Hemorrhagic Telangiectasia” at the annual meeting for the Society for Obstetric Anesthesia and Perinatology. Dr. Manigrasso will be presenting on Saturday May 14th in Chicago.
Multiple congratulations to Dr. Selva Baltan, first for becoming a study section member of the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Preclinical Assessment Network (SPAN), and second, for being invited to become an Associate Editor for Frontiers in Stroke by Dr. Jaroslaw Aronowski, the Chief Editor of the Mechanisms, Models, and Biomarkers of Stroke section.
Congratulations to Dr. Sydney Rose for her publication in the New England Journal of Medicine titled Tranexamic Acid in Patients Undergoing Noncardiac Surgery, as part of the POISE-3 trial she conducted at OHSU. This was a large international multi-institutional randomized controlled trial that examined the effects of transexamic acid versus placebo on bleeding and vascular events in patients undergoing non-cardiac surgery, who are at elevated risk of bleeding, vascular events, or both. The study showed that among these patients, TXA administration reduced the overall risk of life-threatening, major, and critical organ bleeding, and was unable to exclude a small increase in risk of cardiovascular complications.
Congratulations to Sarah Catherine Baker, a third year PMCB PhD Candidate in Dr. Julie Saugstad’s laboratory, who was awarded a prestigious grant from the Oregon Tax Check-off Alzheimer’s Research Fund, managed by the Oregon Partnership for Alzheimer’s Research (OPAR). The award will fund a project that investigates how enlarged endosomes and extracellular vesicles contribute to the mechanisms of Alzheimer’s disease, and includes the development of induced pluripotent stem cells as a model system. Sarah Cate is grateful for the opportunity and excited to get started on this study!
Congratulations to Sierra Smith, a fourth year NGP PhD Candidate in Dr. Julie Saugstad’s laboratory, who was invited to attend the 2022 Gordon Research Conference (GRC) on “Neurobiology of Brain Disorders” in Castelldefels, Spain this August. Sierra was also invited to the “Neurobiology of Brain Disorders" Gordon Research Seminar (GRS) a 2-day meeting for students, which takes place just prior to the start of the associated GRC and was selected to receive a Carl Storm Underrepresented Minority Fellowship to support her participation in the meeting.
Congratulations to Dr. Julie Saugstad and members of her lab team including Dr. Ursula Sandau, Trevor McFarland, and Sierra Smith for publishing their manuscript “Differential Effects of APOE Genotype on MicroRNA Cargo of Cerebrospinal Fluid Extracellular Vesicles in Females with Alzheimer’s Disease Compared to Males”, in Frontiers in Cell and Developmental Biology in March 2022. The article was included in Frontiers Research Topics collection “Exosomes: Message in a Vesicle”. The primary goal of the study was to investigate the effect of known Alzheimer’s disease (AD) risk factors - sex and APOE genotype - on the miRNA cargo of extracellular vesicles (EVs) in human cerebrospinal fluid (CSF). Circulating EVs hold great potential to serve as biomarkers for neurological disorders considering that their cargo is informed by disease state, yet broad profiles of EV cargo that take into account APOE-e4 status and sex have yet to be performed for AD patients. Saugstad’s team showed that AD, sex, and APOE-e4 status all impact CSF EV miRNA levels. Importantly, APOE-e4 status within each sex altered different subsets of miRNAs. Moreover, miRNAs altered in AD CSF EVs predicted gene targets and pathways known to contribute to neurodegeneration in AD. Together, their data demonstrate the need to perform large scale studies that consider key biological factors in addition to the disease state to more precisely define biomarker profiles for the at-risk population.
Congratulations to Drs. Nabil Alkayed, Jim Cao, Zu Yuan Qian, Catherine Davis, Wei Fan, and Helen Liu, for the publication of their manuscript Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR published in the American Journal of Physiology- Cell Physiology.
Clinical
Drs. Scott Mist and Colin Gold will be representing OHSU at the International Congress on Integrative Medicine and Health in May. The International Congress is convened by the Academic Consortium for Integrative Medicine and Health. The consortium, of which OHSU is a member, is a collective of over 60 academic medical centers with programs in integrative medicine. Scientists, educators, practitioners and policy-makers from the domestic and international communities will come together to highlight scientific advances pertaining to the field of integrative medicine and health. More than 1,000 researchers, educators, clinicians, and trainees from around the world are expected to attend.