Mrs. Swarbrick received her B.S. in Biochemistry and Cell Biology from the University of California, San Diego in 1999. First as an undergraduate in San Diego and then following graduation, as a research assistant at the University of Manchester, Manchester, England, she gained laboratory experience in Biochemistry and Genetics. Since July, 2001,Mrs. Swarbrick has worked in David and Deborah Lewinsohn's laboratories and has extensive experience in the isolation and characterization of CD8+ T cell clones, and utilizing ELISPOT, ELISA, and FACS analysis to characterize T cell clones and T cells in peripheral blood. She also has extensive experience using IFN-γELISPOT and synthetic peptide pools to measure antigen-specific T cell responses in humans and Rhesus monkeys and has defined the epitope and restricting allele of Mtb-specific Class Ia-restricted T cell clones.
Since July 2003, she has acted as laboratory manager for both David Lewinsohn and Deborah Lewinsohn, with responsibility for training and oversight of laboratory personnel and for administrative grants management. She was the project manager for two NIH T cell epitope discovery contracts, (HHSN272200900053C and HHSN266200400081C) as well as the administrative manager of the Mucosal Immunity Study Team Infrastructure and Opportunities Fund (MIST IOF) funded by an NIH consortium, U01AI095776. She is currently the project manager for the "Targeting MAIT cells for TB vaccines" grant funded by the Bill and Melinda Gates Foundation.
Megan received her B.S. in Biology from Pacific University in 2001. She joined the Lewinsohn lab in November of 2004, and her primary project is the NIH funded Large Scale T-Cell Epitope Discovery contract, who's purpose is to define immunodominant CD8 antigens and epitopes from Mycobacterium tuberculosis. Her role in this project also includes overseeing the clinical validation of these antigens and epitopes at our collaborative site in Kampala Uganda. Her other projects include working with Dr. Marielle Gold and the Gold lab in determining the role of IL-12 in the human immune response to Tb infection, and phenotyping MAIT cells which includes assisting with experiments and planning in Durban, South Africa with Dr. Emily Wong at KRITH (Kwa-Zulu Natal Research Institute for Tb and HIV).
Meghan received her B.S. in Biology from Washington State University in 2004 and began working as a Research Assistant with the Lewinsohn Lab in November of that same year. Her primary project is the NIH Large Scale T-cell Epitope Discovery contract that was first awarded to the Lewinsohn lab in 2004. The aim of this project is to define immunodominant CD8 antigens and epitopes from Mycobacterium tuberculosis. She is also involved in projects to determine the roll of ex-vivo CD8 t-cells to kill Tb infected APCs, as well as the antigen processing pathway of HLA-C restricted epitopes.
Elyse graduated from the University of Washington in 2010 with a B.S. in Cellular, Molecular, and Developmental Biology, as well as a B.A. in English Language and Literature. She remained in Seattle for four years, working in the field of cellular aging and, later, behavioral neuroscience. Elyse transitioned from Seattle to Portland when she joined the laboratories of Dr. Gold and and Dr. Lewinsohn in 2013. Her work focuses on utilization of a new technology called mass cytometry, and she is currently optimizing the technique for use in several projects.