Keynotes and highlights
Chuan He, Ph.D.
John T. Wilson Distinguished Service Professor, Department of Chemistry, and director, the Institute for Biophysical Dynamics at the University of Chicago
Joint professor, Department of Chemical Biology, and director, the Synthetic and Functional Biomolecules Center at Peking University
Monday, May 4 :: 4 to 5 p.m. :: OHSU Auditorium"Reversible RNA and DNA methylation in gene expression regulation"
He was born in P. R. China in 1972 and received his B.S. in 1994 from the University of Science and Technology of China. He received his Ph.D. in chemistry from Massachusetts Institute of Technology in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000 to 2002, he joined the University of Chicago as an assistant professor, and was promoted to associate professor in 2008, professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, epigenetics, cell biology, molecular biology, biochemistry, structural biology, and genomics. He's recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects post-transcriptional gene expression regulation. He has been selected as an Investigator of the Howard Hughes Medical Institute in 2013.
Dr. He's talk is sponsored by the Graduate Student Organization.
Moritz Helmstaedter, Ph.D.
Director of the Department of Connectomics
Max Planck Institute for Brain Research, Frankfurt, Germany
Tuesday, May 5 :: 11 a.m. to 12 p.m. :: OHSU Auditorium
"Connectomics: The dense reconstruction of neuronal circuits"
Moritz Helmstaedter is a neuroscientist dedicated to mapping connectomes: the complex networks of nerve cells in the brain.His research is focused on deciphering how the cerebral cortex stores sensory experience and uses it to detect objects in the current environment. A medical doctor and physicist by training, Helmstaedter completed his doctoral thesis with Nobel laureate Bert Sakmann at the Max Planck Institute in Heidelberg, Germany. During his post-doctoral work, together with Winfried Denk and Kevin Briggman, he developed methods to map nerve cell networks using electron microscopes and computer analysis tools. This is making it possible for the first time to decipher large complex networks in the brain at single-cell resolution. Helmstaedter has pioneered crowd sourcing for connectomics, engaging several hundred undergraduates to work together to analyze neuronal networks. He is now collaborating with game developers to build mobile and browser games, aiming at motivating thousands of curious minds to solve the task of reconstructing the powerful and fascinating neuronal networks of the brain online.
Dr. Helmstaedter's talk is sponsored by the Jungers Center for Neurosciences Research and the OHSU Office of the Senior Vice President for Research.
New Faculty Lightning Rounds
Tuesday, May 5 :: 3:30 to 5:30 p.m. :: Old Library Auditorium
What new research is under way at OHSU? Who are the movers and shakers among new faculty? Find out during Research Week 2015, at the debut of New Faculty Lightning Rounds.
This event allows faculty who have been at OHSU since January 2013 to showcase their project or program in a five-minute, one-slide presentation to an audience of scientists and others in the OHSU community.
Mock Study Section
Thursday, May 7 :: 12 to 1:30 p.m. :: Old Library AuditoriumYou are invited to watch seasoned reviewers discuss NIH proposals as if you were there! The Mock NIH Study Section, led by Charles Rafferty, Ph.D., will review NIH K career development and R01 applications with a panel of OHSU faculty acting as reviewers. This event will demonstrate how grants are evaluated and discussed through the NIH peer review process – and provide insight into improving your own grantsmanship. In addition, we need your participation! The audience will be asked to score the applications with results displaying in real time.
In preparation for the event, please read the two grant applications – the K23 and the R01 – and browse through the NIH review materials, including critique templates, review guidance and NIH scoring table. If you’re short on time, read the R01′s Specific Aims and the K23′s Career Development Plan. As you will see, these are actual NIH proposals that have been redacted to protect the innocent.
All materials can be found here. You need your OHSU credentials to log in.
Charles N. Rafferty, Ph.D., is a health research and grants policy consultant with extensive experience in managing research programs and planning and conducting peer review in environmental, and occupational health and clinical research in musculoskeletal, skin, and rheumatic diseases. He recently retired from his position as Chief of the Scientific Review Branch at the National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS) at the National Institutes of Health (NIH). In this position, he oversaw all grant and contract peer review activities carried out by NIAMS.
The Mock Study Section is sponsored by Oregon Clinical & Translational Research Institute.
Papers of the Year talks
Thursday, May 7 :: 3 to 4:30 p.m. :: Old Library Auditorium
Outstanding Journal Article of the Year
Each year, excellent student papers are nominated by School of Medicine faculty members. Awards are decided by the Graduate Studies Awards Committee and are based on the novelty of the findings and impact of the work. This year's winning paper is:
Chia-Hsueh Lee, Ph.D.
Lee CH, et al. NMDA receptor structures reveal subunit arrangement and pore architecture. Nature. 2014 Jul 10:511(7508):191-7.
Chia-Hsueh Lee, Ph.D., is now a post-doctoral associate in the Laboratory of Molecular Neurobiology and Biophysics at Rockefeller University in New York, NY so he will not be accepting his award in person.
Alumni Association Awards
The Alumni Association Paper Competitions are annual events established to showcase the research efforts of the School of Medicine's residents and postdoctoral fellows.
Postdoctoral Paper of the Year
Ev McClendon, Ph.D.
McClendon E, et al. Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons. Ann Neurol. 2014 Apr;75(4):508-24
Resident Paper of the Year
Kenneth Lim, M.D., Ph.D.
Lim K, et al. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation. 2012 May 8;125(18):2243-55.