Vivek K. Unni, M.D., Ph.D.
- Email:
- click here
- Office:
- 503 494-7772
Lab Page: http://www.ohsu.edu/xd/research/centers-institutes/neurology/jungers-center/index.cfm
Assistant Professor
Background
Dr. Unni’s research focuses on understanding the role of the protein alpha-synuclein in the mechanisms of Parkinson’s Disease (PD). Multiple lines of evidence suggest that simply increasing levels of this protein by seemingly modest amounts can cause both genetic and idiopathic forms of PD. Dr. Unni uses transgenic models which over-express alpha-synuclein to study how abnormally high levels of this protein cause self-aggregation and neuronal dysfunction in the living brain, using advanced biochemical and in vivo multiphoton imaging techniques.
Selected Publications
"Guidelines for the use and interpretation of assays for monitoring autophagy,"
"Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.,"
"Alpha-synuclein's degradation in vivo: Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease,"
"Distinct roles in vivo for the Ubiquitin-Proteasome system and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein,"
"Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study,"
