Robert L. Schelonka, M.D.

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Background

Dr. Schelonka's research focuses on understanding the cellular and molecular basis for the relative immune deficiency of infancy and the unusually high risk of developing serious infections in prematurely born infants. Generating knock in targeted mutations of the alleles encoding the T and B cell antigen receptors in mice, Dr. Schelonka has shown how alterations in the immune repertoire affect the host response to specific antigens. Dr. Schelonka has participated in clinical trials examining the efficacy of immune-modifying monoclonal and polyclonal antibody preparations to enhance immune function and reduce the risk of developing serious bacterial or fungal infection.

Selected Publications

"Recirculating bone marrow B cells in C57BL/6 mice are more tolerant of highly hydrophobic and highly charged CDR-H3s than those in BALB/c mice," European Journal of Immunology (Vol: 43, Issue: 3, Page 629-640) - 2013

"Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections," Clinical Infectious Diseases (Vol: 55, Issue: 11, Page 1495-1502) - 2012

"Cytokine profiles of preterm neonates with fungal and bacterial sepsis," Pediatric Research (Vol: 72, Issue: 2, Page 212-220) - 2012

"Type V Aplasia Cutis Congenita: Case Report, Review of the Literature, and Proposed Treatment Algorithm," Pediatric Dermatology (Vol: , Issue: , Page ) - 2012

"Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: A randomized trial," Journal of Pediatrics (Vol: 159, Issue: 6, Page 900-906.e1) - 2011

"Population pharmacokinetics of meropenem in plasma and cerebrospinal fluid of infants with suspected or complicated intra-abdominal infections," Pediatric Infectious Disease Journal (Vol: 30, Issue: 10, Page 844-849) - 2011

"Absence of N addition facilitates B cell development, but impairs immune responses," Immunogenetics (Vol: 63, Issue: 9, Page 599-609) - 2011

"Fetal and Neonatal Morbidity and Mortality Following Delivery After Previous Cesarean," Clinics in Perinatology (Vol: 38, Issue: 2, Page 311-319) - 2011

"T cell cytokines and the risk of blood stream infection in extremely low birth weight infants," Cytokine (Vol: 53, Issue: 2, Page 249-255) - 2011

"Nasopharyngeal carriage of Streptococcus Pneumoniae in very low-birth-weight infants after administration of heptavalent pneumococcal conjugate vaccine," Archives of Pediatrics and Adolescent Medicine (Vol: 164, Issue: 12, Page 1173-1175) - 2010

"The peritoneal cavity B-2 antibody repertoire appears to reflect many of the same selective pressures that shape the B-1a and B-1b repertoires," Journal of Immunology (Vol: 185, Issue: 10, Page 6085-6095) - 2010

"The CDR-H3 repertoire from TdT-deficient adult bone marrow is a close, but not exact, homologue of the CDR-H3 repertoire from perinatal liver," Journal of Immunology (Vol: 185, Issue: 10, Page 6075-6084) - 2010

"D_H and J_H usage in murine fetal liver mirrors that of human fetal liver," Immunogenetics (Vol: 62, Issue: 10, Page 653-666) - 2010

"Heptavalent pneumococcal conjugate vaccine immunogenicity in very-low-birth-weight, premature infants," Pediatric Infectious Disease Journal (Vol: 29, Issue: 7, Page 600-606) - 2010

"Editorial: Oxygen for cyanotic neonates: Friend or foe?," Pediatric Health (Vol: 4, Issue: 1, Page 1-3) - 2010

"The oxygen conundrum for infants with suspected congenital heart disease," Neonatology (Vol: 97, Issue: 2, Page 163-164) - 2010

"Genetic control of DH reading frame and its effect on B-cell development and antigen-specifc antibody production," Critical Reviews in Immunology (Vol: 30, Issue: 4, Page 327-344) - 2010

"Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine," Laboratory Investigation (Vol: 90, Issue: 1, Page 128-139) - 2010

"Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis," Seminars in Fetal and Neonatal Medicine (Vol: 14, Issue: 4, Page 190-199) - 2009

"Corrigendum to "Multiple locus variable tandem repeats analysis of meticillin-resistant Staphylococcus aureus discriminates within USA pulsed-field gel electrophoresis types^{{star, open}} [Journal of Hospital Infection 2009; 71: 333-339]" (DOI:10.1016/j.jhin.2008.12.011)," Journal of Hospital Infection (Vol: 72, Issue: 3, Page 284-) - 2009

"Multiple-locus variable-number tandem-repeat analysis of meticillin-resistant Staphylococcus aureus discriminates within USA pulsed-field gel electrophoresis types," Journal of Hospital Infection (Vol: 71, Issue: 4, Page 333-339) - 2009

"Regulation of repertoire development through genetic control of D _H reading frame preference," Journal of Immunology (Vol: 181, Issue: 12, Page 8416-8424) - 2008

"Preferential use of D_H reading frame 2 alters B cell development and antigen-specific antibody production," Journal of Immunology (Vol: 181, Issue: 12, Page 8409-8415) - 2008

"Immune modification to prevent nosocomial sepsis in hospitalized newborns," NeoReviews (Vol: 9, Issue: 5, Page e199-e205) - 2008

"Genital tract methicillin-resistant Staphylococcus aureus: Risk of vertical transmission in pregnant women," Obstetrics and Gynecology (Vol: 111, Issue: 1, Page 113-118) - 2008