OHSU

Thomas S. Scanlan, Ph.D.

Head Shot of Thomas Scanlan

Background

The current research in the Scanlan Lab is centered broadly in the area of hormone action, with an emphasis on the classic endocrine modulators belonging to the steroid/thyroid family. These hormones coordinate a variety of important physiologic functions in development and homeostasis, and they mediate the regulation with exquisite selectivity. One of the Lab's primary activities is to develop an understanding of the molecular basis of the tissue-selectivity of these hormones using a multidisciplinary approach that involves synthetic chemistry, biochemistry, cell biology, and ultimately


Summary of Current Research


Selected Publications

"Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4," Endocrinology (Vol: 153, Issue: 11, Page 5659-5667) - 2012

"Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway," Endocrinology (Vol: 153, Issue: 11, Page 5143-5149) - 2012

"Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry," Journal of Chromatography A (Vol: 1256, Issue: , Page 89-97) - 2012

"Does the aromatic l-amino acid decarboxylase contribute to thyronamine biosynthesis?," Molecular and Cellular Endocrinology (Vol: 349, Issue: 2, Page 195-201) - 2012

"Evidence for functional trace amine associated receptor-1 in normal and malignant B cells," Leukemia Research (Vol: 36, Issue: 2, Page 245-249) - 2012

 

Contact

  Email Thomas Scanlan

503 494-9292

Memberships & Associations

Professor of Physiology and Pharmacology
Director, Program in Chemical Biology