OHSU

Holly L Rosenzweig, Ph.D.

Head Shot of Holly Rosenzweig

Research Assistant Professor, Department of Ophthalmology, Adjunct Faculty, Department of Molecular Microbiology & Immunology

Email: 
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Phone: 
503 494-8157
Office: 
503 494-4029

Background

  • Role of innate immunity in injury responses of the eye and joint
  • Animal models for diseases involving arthritis and uveitis
  • Professional Affiliations:

  • Association for Research in Vision and Ophthalmology
  • Association of Rheumatology Health Professionals
  • Professional Experience:

  • Postdoctoral fellowship: Ocular inflammation, Oregon Heath & Science University, mentor: James Rosenbaum, 2006-2009
  • Assistant Professor: Ophthalmology, Oregon Heath & Science University, 2009-present
  • Adjunct faculty: Molecular Microbiology & Immunology, Oregon Heath & Science University, 2009-present
  • Selected, recent publications

  • Rosenzweig HL, Martin, TM, Jann MM, Planck SR, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci (2008); 49(4): 1518-24.
  • Rosenbaum JT, Rosenzweig HL, Smith JR, Martin TM, Planck SR. Uveitis secondary to bacterial products. Ophthalmic Res (2008); 40(3-4): 165-8.
  • Rosenzweig HL, Martin TM, Planck SR, Jann MM, Smith JR, Glant TT, van Eden W, Davey MP, Rosenbaum JT. Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis. Ophthalmic Res (2008); 40(3-4): 189-92.
  • Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. Activation of NOD2 in vivo induced IL-1 beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol (2008); 84(2): 529-36
  • Rosenzweig HL, Galster KT, Planck SR, Rosenbaum JT. NOD1 is expressed in the eye and functionally contributes to IL-1& beta; dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci (2008); 50(4): 1746-53.
  • Rosenzweig HL, Kawagushi T, Martin TM, Planck SR, Davey MP, Rosenbaum JT. Nucleotide Oligomerization Domain-2 (NOD2)-Induced Uveitis is Dependent on IFN?. Invest Ophthalmol Vis Sci (2008); 50(4): 1739-45.
  • Rosenzweig HL, Jann MM, Glant TT, Martin TM, Planck SR, van Eden W, van Kooten PJS, Flavell RA, Kobayashi K, Rosenbaum JT, Davey MP. Activation of Nucleotide Oligomerization Domain Two Exacerbates a Murine Model of Proteoglycan-Induced Arthritis. J Leukoc Biol (2009); 85(4): 711-18.
  • Rosenzweig HL, Jann MJ, Vance EE, Planck SR, Rosenbaum JT, Davey MP. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Arthritis Rheum (2010); 62(4): 1051.

  • Selected Publications

    "Investigation of the peptidoglycan sensing molecule, PGLYRP-2, in murine inflammatory uveitis," British Journal of Ophthalmology (Vol: 97, Issue: 4, Page 504-510) - 2013

    "Spondyloarthritis: The eyes have it: Uveitis in patients with spondyloarthritis," Nature Reviews Rheumatology (Vol: 8, Issue: 5, Page 249-250) - 2012

    "Impact of IL-1 signalling on experimental uveitis and arthritis," Annals of the Rheumatic Diseases (Vol: 71, Issue: 5, Page 753-760) - 2012

    "Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis," Arthritis and Rheumatism (Vol: 64, Issue: 3, Page 762-771) - 2012

    "The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis," Inflammation Research (Vol: 61, Issue: 3, Page 225-231) - 2012

     

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      Email Holly Rosenzweig

    503 494-8157

    Memberships & Associations

    Association for Research in Vision and Ophthalmology

    Association of Rheumatology Health Professionals