Holly L Rosenzweig, Ph.D.

Email:: click here
Phone:: 503 494-8157
Office:: 503 494-4029

Background

Role of innate immunity in injury responses of the eye and joint

Animal models for diseases involving arthritis and uveitis

Professional Affiliations:

Association for Research in Vision and Ophthalmology

Association of Rheumatology Health Professionals

Professional Experience:

Postdoctoral fellowship: Ocular inflammation, Oregon Heath & Science University, mentor: James Rosenbaum, 2006-2009

Assistant Professor: Ophthalmology, Oregon Heath & Science University, 2009-present

Adjunct faculty: Molecular Microbiology & Immunology, Oregon Heath & Science University, 2009-present

Selected, recent publications

Rosenzweig HL, Martin, TM, Jann MM, Planck SR, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci (2008); 49(4): 1518-24.

Rosenbaum JT, Rosenzweig HL, Smith JR, Martin TM, Planck SR. Uveitis secondary to bacterial products. Ophthalmic Res (2008); 40(3-4): 165-8.

Rosenzweig HL, Martin TM, Planck SR, Jann MM, Smith JR, Glant TT, van Eden W, Davey MP, Rosenbaum JT. Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis. Ophthalmic Res (2008); 40(3-4): 189-92.

Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. Activation of NOD2 in vivo induced IL-1 beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol (2008); 84(2): 529-36

Rosenzweig HL, Galster KT, Planck SR, Rosenbaum JT. NOD1 is expressed in the eye and functionally contributes to IL-1& beta; dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci (2008); 50(4): 1746-53.

Rosenzweig HL, Kawagushi T, Martin TM, Planck SR, Davey MP, Rosenbaum JT. Nucleotide Oligomerization Domain-2 (NOD2)-Induced Uveitis is Dependent on IFN. Invest Ophthalmol Vis Sci (2008); 50(4): 1739-45.

Rosenzweig HL, Jann MM, Glant TT, Martin TM, Planck SR, van Eden W, van Kooten PJS, Flavell RA, Kobayashi K, Rosenbaum JT, Davey MP. Activation of Nucleotide Oligomerization Domain Two Exacerbates a Murine Model of Proteoglycan-Induced Arthritis. J Leukoc Biol (2009); 85(4): 711-18.

Rosenzweig HL, Jann MJ, Vance EE, Planck SR, Rosenbaum JT, Davey MP. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Arthritis Rheum (2010); 62(4): 1051.

Selected Publications

"Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis.," Arthritis and rheumatism (Vol: 64, Issue: 3, Page 762-71) - 2012

"The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis.," Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Vol: 61, Issue: 3, Page 225-31) - 2012

"NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice.," Investigative ophthalmology & visual science (Vol: 52, Issue: 7, Page 4106-12) - 2011

"Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice.," Inflammation research : official journal of the European Histamine Research Society ... [et al.] (Vol: 60, Issue: 7, Page 705-14) - 2011

"NLRs in immune privileged sites.," Current opinion in pharmacology (Vol: 11, Issue: 4, Page 423-8) - 2011

"Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan.," Arthritis and rheumatism (Vol: 62, Issue: 4, Page 1051-9) - 2010

"NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice.," Investigative ophthalmology & visual science (Vol: 50, Issue: 4, Page 1746-53) - 2009

"Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma.," Investigative ophthalmology & visual science (Vol: 50, Issue: 4, Page 1739-45) - 2009

"Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis.," Journal of leukocyte biology (Vol: 85, Issue: 4, Page 711-8) - 2009

"BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.," Arthritis research & therapy (Vol: 11, Issue: 1, Page R21) - 2009

"Nucleotide oligomerization domain-2 interacts with 2'-5'-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells.," Molecular immunology (Vol: 47, Issue: 2-3, Page 560-6) - 2009

"NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis.," Investigative ophthalmology & visual science (Vol: 49, Issue: 4, Page 1518-24) - 2008

"Uveitis secondary to bacterial products.," Ophthalmic research (Vol: 40, Issue: 3-4, Page 165-8) - 2008

"Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis.," Ophthalmic research (Vol: 40, Issue: 3-4, Page 189-92) - 2008

"Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.," Journal of leukocyte biology (Vol: 84, Issue: 2, Page 529-36) - 2008

"Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance.," Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (Vol: 27, Issue: 10, Page 1663-74) - 2007

"Neuroprotection by osteopontin in stroke.," Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (Vol: 25, Issue: 2, Page 217-25) - 2005

"Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice.," Stroke; a journal of cerebral circulation (Vol: 35, Issue: 11, Page 2576-81) - 2004

"Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks.," Journal of neuroimmunology (Vol: 156, Issue: 1-2, Page 31-41) - 2004

"Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states.," Lancet (Vol: 362, Issue: 9389, Page 1028-37) - 2003

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