OHSU

Jacob Raber, Ph.D.

Head Shot of Jacob Raber
Email: 
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Phone: 
503 494-1524
Lab Phone: 
503 494-1431

Background

Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.

We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.


Summary of Current Research

Research Interests Include; aging, alzheimer's disease, androgen receptor, sex differences, histamine, apoE, methamphetamine, irradiation, neurogenesis, cognitive function, behavioral


Selected Publications

"Non-replication of an association of Apolipoprotein E2 with sinistrality," Laterality (Vol: 18, Issue: 2, Page 251-261) - 2013

"Role of mGluR4 in acquisition of fear learning and memory," Neuropharmacology (Vol: 66, Issue: , Page 365-372) - 2013

"Correcting deregulated Fxyd1 expression ameliorates a behavioral impairment in a mouse model of Rett syndrome," Brain Research (Vol: 1496, Issue: , Page 104-114) - 2013

"Paradoxical effects of apolipoprotein e on cognitive function and clinical progression in mice with experimental autoimmune encephalomyelitis," Pharmacology Biochemistry and Behavior (Vol: 103, Issue: 4, Page 860-868) - 2013

"ApoE isoform modulates effects of cranial 56Fe irradiation on spatial learning and memory in the water maze," Behavioural Brain Research (Vol: 237, Issue: 1, Page 207-214) - 2013

 

Contact

  Email Jacob Raber

503 494-1524