Martin Pike, Ph.D.

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Background

Dr. Pike's current research is focused on studying the pathophysiology of brain diseases (stroke, malignant glioma, alzheimers) using MRI/MRS in tandem with other approaches. His lab employs dynamic contrast MRI approaches to investigate anti-angiogenic/anti-tumor treatment strategies employing mouse models of malignant glioma. His group is also investigating blood brain barrier disruption in stroke and stroke neuroprotection strategies. MR based molecular imaging approaches are also being employed to investigate stroke related inflammation.

Summary of Current Research

Dr. Pike received his undergraduate degree from Williams College in Williamstown, MA in 1978 and his doctoral degree from SUNY in the Department of Chemistry in 1985. He was an NIH Postdoctoral Fellow at The Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, MD (1985-88), Dr. Pike was a faculty member at the Department of Medicine, Division of Cardiovascular Disease and Department of Cell Biology at the University of Alabama at Birmingham from 1988 to 2008. He joined the AIRC in 2007 as a Visiting Scholar and 2008 as an Associate Scientist and full member of the OHSU Knight Cancer Institute.

Selected Publications

"Cancer nanomedicine," Journal of Nanomaterials (Vol: 2013, Issue: , Page ) - 2013

"Estradiol modulates post-ischemic cerebral vascular remodeling and improves long-term functional outcome in a rat model of stroke," Brain Research (Vol: 1461, Issue: , Page 76-86) - 2012

"Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination," Journal of Magnetic Resonance (Vol: 206, Issue: 2, Page 190-199) - 2010

"A new model of cortical stroke in the rhesus macaque," Journal of Cerebral Blood Flow and Metabolism (Vol: 29, Issue: 6, Page 1175-1186) - 2009

"Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model," Journal of Cerebral Blood Flow and Metabolism (Vol: 29, Issue: 4, Page 853-860) - 2009

"High-resolution longitudinal assessment of flow and permeability in mouse glioma vasculature: Sequential small molecule and SPIO dynamic contrast agent MRI," Magnetic Resonance in Medicine (Vol: 61, Issue: 3, Page 615-625) - 2009

"Effects of G207, a conditionally replication-competent oncolytic herpes simplex virus, on the developing mammalian brain," Journal of NeuroVirology (Vol: 13, Issue: 2, Page 118-129) - 2007

"Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus," Development (Vol: 132, Issue: 23, Page 5329-5339) - 2005

"Fasudil prevents K_ATP channel-induced improvement in postischemic functional recovery," American Journal of Physiology - Heart and Circulatory Physiology (Vol: 288, Issue: 6 57-6, Page H3011-H3015) - 2005

"Early reperfusion levels of Na⁺ and Ca²⁺ are strongly associated with postischemic functional recovery but are disassociated from K_ATP channel-induced cardioprotection," Journal of Molecular and Cellular Cardiology (Vol: 37, Issue: 2, Page 483-496) - 2004

"The effect of K_ATP channel activation on myocardial cationic and energetic status during ischemia and reperfusion: Role in cardioprotection," Journal of Molecular and Cellular Cardiology (Vol: 33, Issue: 3, Page 545-560) - 2001

"Simultaneous multicompartment intracellular Ca²⁺ measurements in the perfused heart using ¹⁹F NMR spectroscopy," Magnetic Resonance in Medicine (Vol: 35, Issue: 5, Page 640-647) - 1996

"²³Na and ³¹P nuclear magnetic resonance studies of ischemia-induced ventricular fibrillation: Alterations of intracellular Na⁺ and cellular energy," Circulation Research (Vol: 77, Issue: 2, Page 394-406) - 1995

"Nuclear magnetic resonance studies of cationic and energetic alterations with oxidant stress in the perfused heart: Modulation with pyruvate and lactate," Circulation Research (Vol: 77, Issue: 4, Page 773-783) - 1995

"Acylcarnitine accumulation does not correlate with reperfusion recovery in palmitate-perfused rat hearts," American Journal of Physiology - Heart and Circulatory Physiology (Vol: 268, Issue: 6 37-6, Page H2505-H2512) - 1995

"Ischemic dysfunction and impaired in hypertensive hypertrophied hearts is associated with exaggerated intracellular sodium accumulation," American Journal of Hypertension (Vol: 7, Issue: 8, Page 745-754) - 1994

"¹H-NMR spectroscopy can accurately quantitate the lipolysis and oxidation of cardiac triacylglycerols," Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism (Vol: 1169, Issue: 2, Page 176-182) - 1993

"NMR measurements of Na⁺ and cellular energy in ischemic rat heart: Role of Na⁺-H⁺ exchange," American Journal of Physiology - Heart and Circulatory Physiology (Vol: 265, Issue: 6 34-6, Page H2017-H2026) - 1993

"The functional recovery of post-ischemic myocardium requires glycolysis during early reperfusion," Journal of Molecular and Cellular Cardiology (Vol: 25, Issue: 3, Page 261-276) - 1993

"²³Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion," American Journal of Physiology - Heart and Circulatory Physiology (Vol: 259, Issue: 6 28-6, Page H1767-H1773) - 1990

"Quantification of [Ca²⁺](i) in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion," Circulation Research (Vol: 66, Issue: 5, Page 1255-1267) - 1990

"NMR study of rat diaphragm exposed to metabolic and compensated metabolic acidosis," Journal of Applied Physiology (Vol: 65, Issue: 5, Page 2278-2284) - 1988

"Ca²⁺ transients in perfused hearts revealed by gated ¹⁹F NMR spectroscopy," Circulation Research (Vol: 63, Issue: 3, Page 673-678) - 1988

"Sodium transport and phosphorus metabolism in sodium-loaded yeast: Simultaneous observation with sodium-23 and phosphorus-31 NMR spectroscopy in vivo," Biochemistry (Vol: 26, Issue: 16, Page 4953-4962) - 1987

"Use of shift reagents for nuclear magnetic resonance studies of the kinetics of ion transfer in cells and perfused hearts.," Circulation (Vol: 72, Issue: 5 Pt 2, Page IV89-93) - 1985