Ashlee Moses, Ph.D.

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Summary of Current Research

Ashlee Moses is a scientist in the Division of Pathobiology and Immunology and an associate professor at the OHSU Vaccine and Gene Therapy Institute. After being awarded her B.S. at Rhodes University in 1985 and an honors degree at the University of the Witwatersrand in 1986, both in South Africa, she earned her Ph.D. at the University of Wollongong in Australia in 1990. She conducted postdoctoral research at the Scripps Research Institute in San Diego and in the department of Molecular Microbiology and Immunology in the School of Medicine, OHSU, and became an assistant professor at OHSU before joining the center in 1999.

Selected Publications

"A comparative mutational analysis of HIV-1 Vpu subtypes B and C for the identification of determinants required to counteract BST-2/Tetherin and enhance viral egress," Virology (Vol: , Issue: , Page ) - 2013

"IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling," PLoS Pathogens (Vol: 9, Issue: 1, Page ) - 2013

"CD31 immunohistochemical staining in kaposi sarcoma," Archives of Pathology and Laboratory Medicine (Vol: 136, Issue: 11, Page 1329-) - 2012

"Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domain," Journal of Biological Chemistry (Vol: 287, Issue: 18, Page 14837-14850) - 2012

"Kaposi's sarcoma and human dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus express CCL21," Journal of Dermatological Science (Vol: 61, Issue: 2, Page 139-142) - 2011

"Viral takeover of the host ubiquitin system," Frontiers in Microbiology (Vol: 2, Issue: JULY, Page ) - 2011

"The great escape: Viral strategies to counter BST-2/ tetherin," PLoS Pathogens (Vol: 6, Issue: 5, Page 1-12) - 2010

"Kaposi sarcoma pathogenesis: A triad of viral infection, oncogenesis and chronic inflammation," Translational Biomedicine (Vol: 1, Issue: 2, Page ) - 2010

"The great escape: viral strategies to counter BST-2/tetherin.," PLoS pathogens (Vol: 6, Issue: 5, Page e1000913) - 2010

"The inflammatory component of Kaposi sarcoma," Experimental and Molecular Pathology (Vol: 87, Issue: 2, Page 163-165) - 2009

"Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus," Journal of Virology (Vol: 83, Issue: 19, Page 9672-9681) - 2009

"Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/tetherin via a Î²TrCP-dependent mechanism," Journal of Virology (Vol: 83, Issue: 16, Page 7931-7947) - 2009

"Characterization of c-Kit expression and activation in KSHV-infected endothelial cells," Virology (Vol: 390, Issue: 2, Page 174-185) - 2009

"Remodeling of endothelial adherens junctions by Kaposi's sarcoma-associated herpesvirus," Journal of Virology (Vol: 82, Issue: 19, Page 9615-9628) - 2008

"Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing," Journal of Virology (Vol: 82, Issue: 13, Page 6524-6535) - 2008

"Cultured human endothelial cells expressing HIV-1 Vpu and Tat support the expansion of malignant B cells from primary central nervous system lymphoma [8]," British Journal of Ophthalmology (Vol: 92, Issue: 2, Page 297-299) - 2008

"The role of angiogenic and wound repair factors during CMV-accelerated transplant vascular sclerosis in rat cardiac transplants," American Journal of Transplantation (Vol: 8, Issue: 2, Page 277-287) - 2008

"Pathology of rituximab-induced Kaposi sarcoma flare," BMC Clinical Pathology (Vol: 8, Issue: 1, Page ) - 2008

"Mechanisms of cytomegalovirus-accelerated vascular disease: Induction of paracrine factors that promote angiogenesis and wound healing," Current Topics in Microbiology and Immunology (Vol: 325, Issue: , Page 397-415) - 2008

"Kaposi's sarcoma: A model of both malignancy and chronic inflammation," Panminerva Medica (Vol: 49, Issue: 3, Page 119-138) - 2007

"Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus," Journal of Virology (Vol: 81, Issue: 15, Page 8050-8062) - 2007

"The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma," Oncogene (Vol: 26, Issue: 14, Page 1995-2005) - 2007

"Endothelial cell- and lymphocyte-based in vitro systems for understanding KSHV biology," Current Topics in Microbiology and Immunology (Vol: 312, Issue: , Page 211-244) - 2007

"Kaposi sarcoma herpesvirus K5 removes CD31/PECAM from endothelial cells," Blood (Vol: 108, Issue: 6, Page 1932-1940) - 2006

"Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus," Cancer Research (Vol: 65, Issue: 12, Page 5084-5095) - 2005