Bruce Magun, Ph.D

Email:: click here
Phone:: 503 494-7811

Background

My major fields of interest involve cellular mechanisms of inflammatory signaling cascades that control the responses to environmental toxic agents.In some studies, the laboratory investigates how proinflammatory signals (cytokines, toxins, and other stressors) interact with surface receptors to activate the stress-activated protein kinases and NF-kappaB and how activation of these pathways leads to transcriptional regulation of genes. Some projects involve the effects of ricin, a potential bioterrorist agent, on activating proinflammatory pathways in vitro and in mouse models.In other studies we are investigating the mechanisms that control the responses keratinocytes to environmental agents such as ultraviolet radiation and xenobiotic toxic agents.

Selected Publications

"Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of Doxorubicin," Cancer Biology and Therapy (Vol: 14, Issue: 1, Page 56-63) - 2013

"Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome," PLoS ONE (Vol: 7, Issue: 5, Page ) - 2012

"Ricin and Shiga toxins: Effects on host cell Signal transduction," Current Topics in Microbiology and Immunology (Vol: 357, Issue: , Page 41-65) - 2012

"Doxorubicin and daunorubicin induce processing and release of interleukin-1Î² through activation of the NLRP3 inflammasome," Cancer Biology and Therapy (Vol: 11, Issue: 12, Page 1008-1016) - 2011

"ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells," Cancer Biology and Therapy (Vol: 10, Issue: 3, Page 258-266) - 2010

"Ricin toxin activates the NALP3 inflammasome," Toxins (Vol: 2, Issue: 6, Page 1500-1514) - 2010

"Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling," Journal of Immunology (Vol: 183, Issue: 2, Page 1419-1426) - 2009

"Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody," Infection and Immunity (Vol: 76, Issue: 10, Page 4469-4478) - 2008

"Fas ligand-induced proinflammatory transcriptional responses in reconstructed human epidermis: Recruitment of the epidermal growth factor receptor and activation of MAP kinases," Journal of Biological Chemistry (Vol: 283, Issue: 2, Page 919-928) - 2008

"Proinflammatory responses of human airway cells to ricin involve stress-activated protein kinases and NF-ÎºB," American Journal of Physiology - Lung Cellular and Molecular Physiology (Vol: 293, Issue: 6, Page L1385-L1394) - 2007

"Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage," American Journal of Pathology (Vol: 170, Issue: 5, Page 1497-1510) - 2007

"Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages," Molecular Immunology (Vol: 44, Issue: 10, Page 2761-2771) - 2007

"Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: Implications for Dermatitis," Journal of Investigative Dermatology (Vol: 126, Issue: 11, Page 2438-2451) - 2006

"Human cytomegalovirus attenuates interleukin-1Î² and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-ÎºB activation," Journal of Virology (Vol: 80, Issue: 11, Page 5588-5598) - 2006

"Cell death-induced activation of epidermal growth factor receptor in keratinocytes: Implications for restricting epidermal damage in dermatitis," Journal of Investigative Dermatology (Vol: 125, Issue: 1, Page 134-142) - 2005

"Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis," Apoptosis (Vol: 10, Issue: 1, Page 153-166) - 2005

"Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs)," Apoptosis (Vol: 10, Issue: 1, Page 167-176) - 2005

"Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and p38 MAPK and provides a mouse model of hemolytic uremic syndrome," American Journal of Pathology (Vol: 166, Issue: 1, Page 323-339) - 2005

"The UV (ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor," Molecular and Cellular Biology (Vol: 22, Issue: 15, Page 5380-5394) - 2002

"Specifically targeting the CD22 receptor of human B-cell lymphomas with RNA damaging agents," Critical Reviews in Oncology/Hematology (Vol: 39, Issue: 1-2, Page 79-86) - 2001

"Activation of NF-ÎºB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs," Molecular and Cellular Biology (Vol: 21, Issue: 1, Page 61-72) - 2001

"Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: Evidence for cytotoxic mechanisms different from inhibition of protein synthesis," Cancer Research (Vol: 60, Issue: 7, Page 1983-1994) - 2000

"Differential requirement for the stress-activated protein kinase/c-Jun NH₂-terminal kinase in RNA damage-induced apoptosis in primary and in immortalized fibroblasts," Molecular Cell Biology Research Communications (Vol: 4, Issue: 2, Page 122-128) - 2000

"Activation of p38 mitogen-activated protein kinase and c-Jun NH₂- terminal kinase by double-stranded RNA and encephalomyocarditis virus: Involvement of RNase L, protein kinase R, and alternative pathways," Molecular and Cellular Biology (Vol: 20, Issue: 2, Page 617-627) - 2000

"Different mechanisms of c-Jun NH₂-terminal kinase-1 (JNK1) activation by ultraviolet-B radiation and by oxidative stressors," Journal of Biological Chemistry (Vol: 274, Issue: 36, Page 25801-25806) - 1999