Charles D. Lopez, M.D., Ph.D.
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- Phone:
- 503 494-6594
- Office:
- 503 494-6594
Associate Professor, Cell and Developmental Biology, OHSU; Hematology/Oncology Fellowship Director
Background
My major research interest is investigating the basic cellular and molecular mechanisms of how tumors form and respond to treatment. By studying how these things work, I hope to find specific molecules that are targets for new cancer treatments. I see patients with gastrointestinal (digestive system) cancers and participate in clinical trials for a variety of gastrointestinal cancers.
Summary of Current Research
Additional Special Interests Tumor biology
Selected Publications
"N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence,"
"Lapatinib and gemcitabine for metastatic pancreatic cancer: A phase II study,"
"New insights into the expanding complexity of the tumor suppressor ASPP2,"
"Phase II study of calcitriol-enhanced docetaxel in patients with previously untreated metastatic or locally advanced pancreatic cancer,"
"Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds,"
