R. Stephen Lloyd, Ph.D.
- Email:
- click here
- Phone:
- 503 494-8638
Lab Page: http://www.ohsu.edu/xd/research/centers-institutes/croet/research/lloyd-mccullough-lab.cfm
Background
DNA repair processes and high fidelity DNA replication represent the major mechanisms to maintain genomic stability. Our laboratory uses multi-disciplinary approaches to focus on:
Summary of Current Research
Dr. R. Stephen Lloyd received his BS in Biology from Florida State University in 1975, majoring in marine pollution biology. His research interests turned to cancer chemotherapy and in 1979, he earned his Ph.D. in Molecular Biology from the University of Texas Graduate School of Biomedical Sciences in Houston, TX. After learning about mechanisms by which DNA can be damaged, he began his career in DNA repair as a postdoctoral fellow at Stanford University in the laboratory of Dr. Philip Hanawalt. Following two years at Stanford, he worked for two more years for a genetic engineering company, before joining the Biochemistry Department at Vanderbilt University in 1983. In his ten-year stay at Vanderbilt, Dr. Lloyd rose through the ranks to Full Professor, and his research focused on both DNA repair and molecular mutagenesis. He was then recruited to the Center for Molecular Science at the University of Texas Medical Branch in which the faculty exclusively specialized in DNA repair mechanisms. During his twelve years at UTMB, he also became the Director of two Centers in Environmental Toxicology. In August 2003, he, along with his wife, Dr. Amanda K. McCullough was recruited to join the CROET faculty at OHSU. Together they have both separate and joint research projects in the research areas described below.
Selected Publications
"Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity,"
"8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction,"
"DNA polymerase β gap-filling translesion DNA synthesis,"
"A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ,"
"Replication of the 2,6-diamino-4-hydroxy- N 5-(methyl)- formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases,"
