Charles Keller

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Background

Dr. Keller’s research focuses on the development of more effective, less toxic therapies for childhood sarcomas including the muscle cancer, rhabdomyosarcoma, and the childhood brain tumor, medulloblastoma. His laboratory's special interest is advanced disease that has spread beyond the initial location of the cancer. Dr. Keller is an Associate Professor and Leader of the Pediatric Cancer Biology Program in the Pape' Family Pediatric Research Institute, Department of Pediatrics. Dr. Keller also directs the Pediatric Preclinical Testing Initiative, an NCI-affiliated childhood cancer drug testing program. Dr. Keller previously attended Tulane University where he received a degree in Biomedical Engineering prior to attending Baylor College of Medicine where he received his M.D. degree. After completing his internship and residency in Pediatrics at Texas Children's Hospital, Dr. Keller trained in Pediatric Hematology-Oncology at the University of Utah.

Selected Publications

"Overcoming autopsy barriers in pediatric cancer research," Pediatric Blood and Cancer (Vol: 60, Issue: 2, Page 204-209) - 2013

"Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma," Oncogene (Vol: 32, Issue: 3, Page 286-295) - 2013

"CCAAT/enhancer binding protein beta is expressed in satellite cells and controls myogenesis," Stem Cells (Vol: 30, Issue: 12, Page 2619-2630) - 2012

"The Not-so-Skinny on Muscle Cancer," Cancer Cell (Vol: 22, Issue: 4, Page 421-422) - 2012

"An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma," Biochemical and Biophysical Research Communications (Vol: 426, Issue: 3, Page 363-368) - 2012

"¹⁸F-FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models," Pediatric Blood and Cancer (Vol: 59, Issue: 3, Page 485-492) - 2012

"CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells," International Journal of Cancer (Vol: 131, Issue: 4, Page E437-E448) - 2012

"Personalized cancer care: Opportunities and challenges in pediatric neuro-oncology," Pediatric Blood and Cancer (Vol: 59, Issue: 1, Page 1-2) - 2012

"Constitutive Notch Activation Upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells," Molecular and Cellular Biology (Vol: 32, Issue: 12, Page 2300-2311) - 2012

"The clinical, research, and social value of autopsy after any cancer death: A perspective from the Children's Oncology Group soft tissue sarcoma committee," Cancer (Vol: 118, Issue: 12, Page 3002-3009) - 2012

"Vascular Contrast Enhanced Micro-CT Imaging of "Radiators" in the Brazilian Free-Tailed Bat (Tadarida Brasiliensis)," Anatomical Record (Vol: 295, Issue: 4, Page 563-566) - 2012

"AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell," Cell Cycle (Vol: 11, Issue: 5, Page 895-908) - 2012

"Preclinical testing of tandutinib in a transgenic medulloblastoma mouse model," Journal of Pediatric Hematology/Oncology (Vol: 34, Issue: 2, Page 116-121) - 2012

"Analyzing pathway design from drug perturbation experiments," 2012 IEEE Statistical Signal Processing Workshop, SSP 2012 (Vol: , Issue: , Page 552-555) - 2012

"Bortezomib stabilizes NOXA and triggers ROS-associated apoptosis in medulloblastoma," Journal of Neuro-Oncology (Vol: 105, Issue: 3, Page 475-483) - 2011

"The long road to immunotherapy for childhood rhabdomyosarcoma," Pediatric Blood and Cancer (Vol: 57, Issue: 6, Page 899-901) - 2011

"Pax7 expressing cells contribute to dermal Wound repair, regulating scar size through a Î²-catenin mediated process," Stem Cells (Vol: 29, Issue: 9, Page 1371-1379) - 2011

"Effective fiber hypertrophy in satellite cell-depleted skeletal muscle," Development (Vol: 138, Issue: 17, Page 3657-3666) - 2011

"Rb1 gene inactivation expands satellite cell and postnatal myoblast pools," Journal of Biological Chemistry (Vol: 286, Issue: 22, Page 19556-19564) - 2011

"Craniorachischisis and omphalocele in a stillborn cynomolgus monkey (Macaca fascicularis)," American Journal of Medical Genetics, Part A (Vol: 155, Issue: 6, Page 1367-1373) - 2011

"MicroCT-based virtual histology evaluation of preclinical medulloblastoma," Molecular Imaging and Biology (Vol: 13, Issue: 3, Page 493-499) - 2011

"IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma," Clinical Cancer Research (Vol: 17, Issue: 9, Page 2757-2766) - 2011

"Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma," Molecular Cancer Therapeutics (Vol: 10, Issue: 4, Page 697-707) - 2011

"MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells," Stem Cells (Vol: 29, Issue: 3, Page 505-516) - 2011

"Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma," Cancer Cell (Vol: 19, Issue: 2, Page 177-191) - 2011