Brett C. Sheppard, M.D.

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503 494-4373


Dr. Sheppard has a focused clinical interest in surgical diseases of the pancreas with a special interest in the care of patients with pancreatic cancer. In addition he maintains expertise in the surgical care of disease of the foregut (stomach and esophagus) and endocrine diseases of the pancreas and the adrenal gland. Whenever possible, Dr. Sheppard utilizes his expertise in MIS for surgical care. Dr. Sheppard is deeply committed to patient safety and the enhancement of the quality of surgical care and is a member of quality care working groups both at OHSU and for the state of Oregon. His research interests are focused on improving outcomes for pancreatic cancer by earlier diagnosis and improved therapy, the enhancement of outcomes in gastro-intestinal (GI) and GI endocrine surgery and the optimization of MIS techniques. He is a member of the OHSU Knight Cancer Institute, the surgical principal investigator for OHSU of the American College of Surgeons Oncology Group and a member of the Southwest Oncology Group. This provides for excellent state of the art interdisciplinary cancer care through clinical trials. In addition he is a member of national and international scientific societies dedicated to progress in patient care for open and MIS GI surgery.

Selected Publications

"Suprarenal retroperitoneal liposarcoma with intracaval tumor thrombus: An imaging mimic of adrenocortical carcinoma," Clinical Imaging (Vol: 38, Issue: 1, Page 75-77) - 2014

"Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer," Molecular Cancer Research (Vol: 12, Issue: 6, Page 924-939) - 2014

"The international normalized ratio overestimates coagulopathy in patients after major hepatectomy," American Journal of Surgery (Vol: 207, Issue: 5, Page 723-727) - 2014

"Bile duct involvement portends poor prognosis in resected gallbladder carcinoma," Gastrointestinal Cancer Research (Vol: 6, Issue: 4, Page 101-105) - 2013

"Coagulopathy after a liver resection: Is it over diagnosed and over treated?," HPB (Vol: 15, Issue: 11, Page 865-871) - 2013


OHSU Knight Cancer Institute

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Memberships & Associations

Alliance for Clinical Trials in Oncology
American Association of Endocrine Surgeons
American College of Gastroenterology
American College of Surgeons-Fellow
American Gastroenterological Association (AGA)
American Hepato Pancreato Biliary Association (AHPBA)
American Pancreas Association (APA)
American Surgical Association (ASA)
MIS Fellowship Council
North Pacific Surgical Association
Pacific Coast Surgical Association
Pancreas Club
Society of American Gastrointestinal Endoscopic Surgeons (SAGES)
Society for Surgery of the Alimentary Tract (SSAT)
Society of Surgical Oncology (SSO)
Southwest Oncology Group (SWOG)
Surgical Outcomes Club (SOC)