Susan L. Orloff, M.D.

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503 494-8500


Dr. Orloff's clinical interests include benign and malignant liver, gall bladder and bile duct tumors; liver, kidney, and pancreas transplantation; hepatobiliary and pancreatic surgery; portal hypertension surgery; organ procurement; hepatocellular carcinoma; cholangiocarcinoma; and benign hepatobiliary diseases.

Dr. Susan L. Orloff is Professor of Surgery and the Director and Chief of the Division of Abdominal Transplantation at Oregon Health and Science University.  She is also Chief of the Liver Transplantation Program at Portland VA Medical Center.  Dr. Orloff received a BA in Biology, graduating Phi Beta Kappa in  her home-town  of La Jolla, at the University of California, San Diego.  She then received her MD degree, graduating AOA, from the University of California, San Francisco in 1984.  She started out in a residency at UCSF in Internal Medicine, but after one year, was bitten by the surgery bug, and was accepted into the general surgery residency at UCSF, completing her residency in 1992.  During her general surgery residency, she spent two years in the Gastrointestinal Research Laboratory of Dr. Haile Debas, at that time the Chair of Surgery, as an awardee of an NIH training grant.   She also spent 4 months in the Department of Surgery Research Laboratory of then Chair, Dr. Bernard Jaffe, at SUNY Downstate, where she learned models of small bowel transplantation in rodents and dogs. After her general surgery residency, she went on to do a fellowship in multiorgan transplantation at UCSF, under the directorship of Dr. Nancy Ascher, completing this in December 1994. Dr. Susan Orloff joined Oregon Health and Science University in 1995, where she has been actively engaged in research, teaching, multiorgan transplantation and hepatobiliary surgery. As Professor of Surgery, she holds joint appointments in the Division of AbdominalTransplantation and the Department of Molecular Microbiology and Immunology. From 2002-2005, Dr. Orloff served as the Medical Director for the Pacific Northwest Transplant Bank, and she has been the Director of Basic Science Research for the OHSU Department of Surgery since 2001. Dr. Orloff established, and now supervises, a highly productive NIH- and VA Merit Review-funded laboratory in transplantation biology and immunology where she mentors post-doctoral fellows, PhD graduate students and general surgery residents.

Currently, she has a busy practice in hepatobiliary surgery and multi-organ abdominal transplantation.   She is also Director of Basic Science Research in the Department of Surgery and, for 12 years, has run an NIH-funded laboratory studying the mechanisms and genomics of CMV accelerated vasculopathy in heart and kidney transplant rodent models. She also has a research interest in the epidemiology, screening, treatments and genomics of hepatocellular carcinoma.  She has over 80 peer-reviewed publications and 18 book chapters, and has presented her work locally, nationally and internationally. She serves as a reviewer for 16 journals and is on the Editorial Board of 3.  She is an active member of numerous surgical societies as well as serving on many institutional, regional and national committees, including serving as the American Surgical Association Governor to the American College of Surgeons.  She is past- President of the Portland Surgical Society, and previous Medical Director of the Pacific Northwest Transplant Bank,

She currently resides in Portland, Oregon on the lovely Willamette River with her husband Dr. Robert Hart and their six-year old son Jackson.

Selected Publications

"Fluorescence-based laser capture microscopy technology facilitates identification of critical in vivo cytomegalovirus transcriptional programs.," Methods in molecular biology (Clifton, N.J.) (Vol: 1119, Page 217-237) - 2014

"Surgical portosystemic shunts in the era of TIPS and liver transplantation are still relevant," HPB (Vol: 16, Issue: 5, Page 481-493) - 2014

"The international normalized ratio overestimates coagulopathy in patients after major hepatectomy," American Journal of Surgery (Vol: 207, Issue: 5, Page 723-727) - 2014

"Unshuntable extrahepatic portal hypertension revisited: 43 years' experience with radical esophagogastrectomy treatment of bleeding esophagogastric varices," American Journal of Surgery (Vol: 207, Issue: 1, Page 46-52) - 2014

"An unusual presentation of altered mental status after orthotopic liver transplantation: Listeria brain abscess," Transplantation (Vol: 95, Issue: 12, Page e72-e73) - 2013


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Memberships & Associations

American Hepato-Pancreato-Biliary Association International Hepato-Pancreato-Biliary Association American College of Surgeons American Society of Transplant Surgeons American Society of Transplantation Alpha Omega Alpha American Association for the study of Liver Disease American Society of Microbiology American Society of Transplant Physicians American Surgical Association Association of Academic Surgeons International Liver Transplant Society North Pacific Surgical Association Oregon Cancer Institute GI Malignancies Program Pacific Coast Surgical Association Portland Surgical Society Society of University Surgeons The Transplantation Society