OHSU

Dawn Nolt, M.D., M.P.H.

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Assistant Professor

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503-418-8100

Background

Dr. Nolt's research focuses on the human immune response against Mycobacterium tuberculosis, to better understand the CD8 T cell response during this chronic infection. Using immune and biochemical techniques, Dr. Nolt is exploring how this pathogen is displayed to CD8 T lymphocytes (in the context of HLA-I) by human dendritic cells. Antigen-specific studies (processing, presentation/loading) and HLA-I trafficking within the dendritic cells are key areas of interest in Dr. Nolt's laboratory. Results of Dr. Nolt's research will advance the field of immunobiology of tuberculosis, and contribute to the development of an improved vaccine against this deadly disease.


Selected Publications

"Hypohidrotic Ectodermal Dysplasia, Osteopetrosis, Lymphedema, and Immunodeficiency in an Infant with Multiple Opportunistic Infections," Pediatric Dermatology - 2013

"The Mycobacterium tuberculosis Phagosome Is a HLA-I Processing Competent Organelle," PLoS Pathogens (Vol: 5, Issue: 4, ) - 2009

"Surveillance stool cultures: To collect or not collect, that is the question," Pediatric Transplantation (Vol: 10, Issue: 2, Page 133-135) - 2006

"Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses," Journal of Immunology (Vol: 175, Issue: 2, Page 1107-1117) - 2005

"Interleukin-12 Therapy Reduces the Number of Immune Cells and Pathology in Lungs of Mice Infected with Mycobacterium tuberculosis," Infection and Immunity (Vol: 72, Issue: 5, Page 2976-2988) - 2004

 

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503-418-8100

Memberships & Associations

  • American Academy of Pediatrics
  • Pediatric Infectious Diseases Society
  • Infectious Diseases Society of America
  • American Association of Immunologists