OHSU

Robb E. Moses, M.D.

Head Shot of Robb Moses
Email: 
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Lab Phone: 
503 494-7703
Office: 
503 494-8307

Background

My lab studies DNA crosslink repair using two model systems. Fanconi anemia is a recessive disease affecting multiple organ systems and results in severe anemia and an increased risk of leukemia. Cells from the patients are hypersensitive to DNA crosslinkers. The Moses group is part of a program project on Fanconi anemia and has participated in the positional cloning of one of the genes, from among at least twelve. The role of the FA genes inrepair of DNA cross links is intriguing not just because of the association with disease, but because the FA cells are competent in all other types of DNA repair tested. Our current work is focused on the role of chromatin remodeling in FA and potential defects in remodeling which might affect ICL repair.

A second project investigates the function a mammalian gene responsible for crosslink repair, the hSNM1 gene. We have isolated the protein encoded by the gene and it is a 5’-exonuclease which is required for intermediate processing in the repair of ICLs.


Selected Publications

"Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis," Molecular Endocrinology (Vol: 28, Issue: 3, Page 395-405) - 2014

"REGγ deficiency promotes premature aging via the casein kinase 1 pathway," Proceedings of the National Academy of Sciences of the United States of America (Vol: 110, Issue: 27, Page 11005-11010) - 2013

"DNA transcription and repair: A confluence," Journal of Biological Chemistry (Vol: 287, Issue: 28, Page 23266-23270) - 2012

"A FANCD2 domain activates Tip60-dependent apoptosis," Cell Biology International (Vol: 34, Issue: 9, Page 893-899) - 2010

"DNA interstrand crosslink repair in mammalian cells," Journal of Cellular Physiology (Vol: 220, Issue: 3, Page 569-573) - 2009

 

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Contact

  Email Robb Moses

503 494-8307

Memberships & Associations

Medical Genetics, 1982