Charles D. Lopez, M.D., Ph.D.

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503 494-6594


My major research interest is investigating the basic cellular and molecular mechanisms of how tumors form and respond to treatment. By studying how these things work, I hope to find specific molecules that are targets for new cancer treatments. I see patients with gastrointestinal (digestive system) cancers and participate in clinical trials for a variety of gastrointestinal cancers.

Summary of Current Research

Additional Special Interests

Tumor biology

Selected Publications

"Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer," Molecular Cancer Research (Vol: 12, Issue: 6, Page 924-939) - 2014

"N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence," Proceedings of the National Academy of Sciences of the United States of America (Vol: 110, Issue: 1, Page 312-317) - 2013

"Putting the pieces together: Necrolytic migratory erythema and the glucagonoma syndrome," Journal of General Internal Medicine (Vol: 28, Issue: 11, Page 1525-1529) - 2013

"Safety and Outcomes Following Resection of Colorectal Liver Metastases in the Era of Current Perioperative Chemotherapy," Journal of Gastrointestinal Surgery (Vol: 17, Issue: 12, Page 2133-2142) - 2013

"Lapatinib and gemcitabine for metastatic pancreatic cancer: A phase II study," American Journal of Clinical Oncology: Cancer Clinical Trials (Vol: 34, Issue: 1, Page 50-52) - 2011


OHSU Knight Cancer Institute

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503 494-6594

Memberships & Associations

American Society of Clinical Oncology Basic Mechanisms of Cancer Therapeutics Study Section , U.S. National Institutes of Health/National Cancer Institute