David M. Koeller, M.D.

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Dr. Koeller specializes in inherited (genetic) disorders of metabolism. He is the Director of the OHSU Metabolic Clinic, and Chief of the Division of Metabolism in the Department of Pediatrics. He also serves as a medical consultant to the Northwest Regional Newborn Screening Program, which provides newborn screening for Oregon, Idaho, Nevada, New Mexico, Alaska, and Hawaii. His clinical and research interests include inherited disorders of metal, fatty acid and organic acid metabolism. He is board certified in Pediatrics and Clinical Biochemical Genetics.

Selected Publications

"Acute lysine overload provokes protein oxidative damage and reduction of antioxidant defenses in the brain of infant glutaryl-CoA dehydrogenase deficient mice: A role for oxidative stress in GA i neuropathology," Journal of the Neurological Sciences (Vol: 344, Issue: 1-2, Page 105-113) - 2014

"Increased glutamate receptor and transporter expression in the cerebral cortex and striatum of Gcdh-/- mice: Possible implications for the neuropathology of glutaric acidemia type I," PLoS ONE (Vol: 9, Issue: 3, ) - 2014

"Reply," Journal of Pediatrics (Vol: 165, Issue: 2, Page 420-422) - 2014

"Reply," Journal of Pediatrics (Vol: 165, Issue: 2, Page 419-420) - 2014

"Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1," Biochimica et Biophysica Acta - Molecular Basis of Disease (Vol: 1832, Issue: 10, Page 1463-1472) - 2013


OHSU Doernbecher Children's Hospital

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