OHSU

Stephen A. Back, M.D., Ph.D.

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Background

The Back Lab focuses on the development of novel strategies to promote regeneration and repair of injury to the developing brain. The lab studies mechanisms by which hypoxia-ischemia triggers cerebral white matter injury, the major cause of cerebral palsy (CP) in survivors of preterm birth. We focus on the oligodendrocyte lineage, as well as several other key cellular components of the white matter. We use several complementary approaches that employ human tissues, tissue culture systems and unique animal models. We also extend these developmental observations to define mechanisms of white matter injury in adult CNS in disorders that include multiple sclerosis and Alzheimer's Disease.


Selected Publications

"Advances in Neonatal Neurology," Clinics in Perinatology (Vol: 41, Issue: 1, Page 17-19) - 2014

"Brain injury in premature neonates: A primary cerebral dysmaturation disorder?," Annals of Neurology (Vol: 75, Issue: 4, Page 469-486) - 2014

"Cerebral White and Gray Matter Injury in Newborns: New Insights into Pathophysiology and Management," Clinics in Perinatology (Vol: 41, Issue: 1, Page 1-24) - 2014

"Isoflurane-induced apoptosis of neurons and oligodendrocytes in the fetal rhesus macaque brain," Anesthesiology (Vol: 120, Issue: 3, Page 626-638) - 2014

"Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons," Annals of Neurology (Vol: 75, Issue: 4, Page 508-524) - 2014

 

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Contact

  Email Stephen Back

503 346-0640