Teresa Puthussery, O.D., Ph.D.
Research Interests Retinal Circuitry, Neurotransmission, Retinal Degeneration, Electrophysiology
Teresa Puthussery earned her Bachelor of Optometry (O.D.) in 2000 and a Ph.D. in retinal neurobiology in 2005 from The University of Melbourne in Australia. In 2007, she was awarded a CJ Martin Biomedical Research Fellowship from the National Health and Medical Research Council of Australia and a Sir Keith Murdoch Fellowship from the American-Australian Association to pursue postdoctoral training in retinal neurophysiology with Dr. Rowland Taylor at OHSU. In 2013, she was promoted to Research Assistant Professor.
Summary of Current Research
The human retina is remarkable in its ability to extract information about form, color and motion from the visual environment. The Puthussery laboratory is interested in the neural mechanisms and circuitry that underlie these abilities. We are also interested in how these neural mechanisms are perturbed in response to photoreceptor degenerations such as Retinitis Pigmentosa and Age-Related Macular Degeneration. We use a multi-faceted experimental approach, combining immunohistochemistry, single-cell electrophysiology, protein biochemistry and confocal/super-resolution imaging to address our research questions. To learn more about current research in the lab, please visit our Lab page.
Puthussery, T., Venkataramani, S., Gayet-Primo, J., Smith, R. G., & Taylor, W. R. (2013). NaV1.1 Channels in Axon Initial Segments of Bipolar Cells Augment Input to Magnocellular Visual Pathways in the Primate Retina. J Neurosci, 33(41), 16045–16059.
Buldyrev, I., Puthussery, T., & Taylor, W. R. (2012). Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell. J Neurophysiol. 107(7):1795-807.
Puthussery, T., Gayet-Primo, J., Taylor, W. R., & Haverkamp, S. (2011). Immunohistochemical identification and synaptic inputs to the diffuse bipolar cell type DB1 in macaque retina. J Comp Neurol, 519(18), 3640–56.
Puthussery, T., Gayet-Primo, J., Taylor, W.R. (2011). Carbonic anhydrase related protein VIII is expressed in rod bipolar cells and alters signaling at the rod bipolar to AII amacrine cell synapse in the mammalian retina. Eur J Neurosci. 34:1419-31.
Puthussery, T., Gayet-primo, J., & Taylor, W. R. (2010). Localization of the Calcium-binding Protein Secretagogin in Cone Bipolar Cells of the Mammalian Retina. J Comp Neurol, 518(4), 513–525.
Puthussery, T., Gayet-Primo, J., Pandey, S., Duvoisin, R. M., & Taylor, W. R. (2009). Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa. Eur J Neurosci, 29(8), 1533–42.
Puthussery, T., & Fletcher, E. (2009). Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents. J Comp Neurol, 513:430-440.
Puthussery, T., Yee, P., Vingrys, A. J., & Fletcher, E. L. (2006). Evidence for the involvement of purinergic P2X receptors in outer retinal processing. Eur J Neurosci 24:7-19.
Puthussery, T., & Fletcher, E. L. (2004). Synaptic localization of P2X7 receptors in the rat retina. J Comp Neurol 472:13-23.