OHSU

Jacob Raber, Ph.D.

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Lab Phone: 
503 494-1431

Background

Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.

We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.


Summary of Current Research

Research Interests Include; aging, alzheimer's disease, androgen receptor, sex differences, histamine, apoE, methamphetamine, irradiation, neurogenesis, cognitive function, behavioral


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Contact

  Email Jacob Raber

503 494-1524