OHSU

Jacob Raber, Ph.D.

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Lab Phone: 
503 494-1431

Background

Our research focuses on effects of genetic factors, such as apoE, and environmental factors on brain structure and function in experimental mouse models of human neurological diseases. Based on what we learn in the mouse models, we try to develop tests and treatment strategies to improve brain function in humans suffering from these diseases. Routinely, we use a combination of behavioral, neuroendocrinological, pharmacological, neurochemical, immunohistochemical, cellular, and molecular approaches.

We developed humanized versions of the mouse object recognition and spatial navigation tests and assess whether they are sensitive to detect effects of sex and apoE4 on cognition in health and disease. These tests might be valuable in identifying biomarkers of cognitive function and susceptibility to cognitive impairments.


Summary of Current Research

Research Interests Include; aging, alzheimer's disease, androgen receptor, sex differences, histamine, apoE, methamphetamine, irradiation, neurogenesis, cognitive function, behavioral


Selected Publications

"28Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of naïve and cognitively tested mice," Radiation Research (Vol: 181, Issue: 4, Page 362-368) - 2014

"Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner," Neurobiology of Disease (Vol: 64, Page 150-162) - 2014

"CD44 is required for spatial memory retention and sensorimotor functions," Behavioural Brain Research (Vol: 275, Page 146-149) - 2014

"Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders," Journal of Pharmacology and Experimental Therapeutics (Vol: 350, Issue: 3, Page 495-505) - 2014

"Exposure to low-dose 56Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells," Radiation Research (Vol: 182, Issue: 1, Page 92-101) - 2014

 

Contact

  Email Jacob Raber

503 494-1524