OHSU

Lisa J Wood, Ph.D., R.N.

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Summary of Current Research

The long-range goal of our research is to effectively treat and manage the most common symptom experienced by cancer patients undergoing chemotherapy, radiation therapy or both; fatigue. To date the molecular mechanisms underlying the initiation and perpetuation of CTRF are not well established, and, the precise role of inflammatory cytokines, if any, in CTRF remains unclear. Our research program utilizes a pre-clinical and clinical approach to examine the relationship between cancer treatment, inflammatory cytokines and CTRF. This “bench to bedside” approach to understanding the cause of CTRF arises from a unique interdisciplinary collaboration among molecular, behavioral, and clinical investigators all working at various points within the spectrum of cancer research at our institution and hence, represents a major innovation in cancer symptom research.


Selected Publications

"The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS): A study using cytokine receptor-deficient mice," Brain, Behavior, and Immunity - 2014

"A role for orexin in cytotoxic chemotherapy-induced fatigue," Brain, Behavior, and Immunity - 2013

"Inflammation and neural signaling: Etiologic mechanisms of the cancer treatment-related symptom cluster," Current Opinion in Supportive and Palliative Care (Vol: 7, Issue: 1, Page 54-59) - 2013

"Preliminary differences in peripheral immune markers and brain metabolites between fatigued and non-fatigued breast cancer survivors: a pilot study," Brain Imaging and Behavior ( Page 1-11) - 2013

"Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of Doxorubicin," Cancer Biology and Therapy (Vol: 14, Issue: 1, Page 56-63) - 2013

 

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Contact

  Email Lisa Wood

503 494-3431