OHSU

Lisa J Wood, Ph.D., R.N.

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Summary of Current Research

The long-range goal of our research is to effectively treat and manage the most common symptom experienced by cancer patients undergoing chemotherapy, radiation therapy or both; fatigue. To date the molecular mechanisms underlying the initiation and perpetuation of CTRF are not well established, and, the precise role of inflammatory cytokines, if any, in CTRF remains unclear. Our research program utilizes a pre-clinical and clinical approach to examine the relationship between cancer treatment, inflammatory cytokines and CTRF. This “bench to bedside” approach to understanding the cause of CTRF arises from a unique interdisciplinary collaboration among molecular, behavioral, and clinical investigators all working at various points within the spectrum of cancer research at our institution and hence, represents a major innovation in cancer symptom research.


Selected Publications

"A role for orexin in cytotoxic chemotherapy-induced fatigue," Brain, Behavior, and Immunity (Vol: 37, Page 84-94) - 2014

"Preliminary differences in peripheral immune markers and brain metabolites between fatigued and non-fatigued breast cancer survivors: a pilot study," Brain Imaging and Behavior (Vol: 8, Issue: 4, Page 506-516) - 2014

"Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia," Journal of Neuroimmunology (Vol: 277, Issue: 1-2, Page 160-167) - 2014

"Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs: Synergistic effects of doxorubicin and vincristine," Cancer Biology and Therapy (Vol: 15, Issue: 10, Page 1395-1403) - 2014

"The role of IL-1β and TNF-α signaling in the genesis of cancer treatment related symptoms (CTRS): A study using cytokine receptor-deficient mice," Brain, Behavior, and Immunity (Vol: 38, Page 66-76) - 2014

 

Contact

  Email Lisa Wood

503 494-3431