William Skach, M.D.
Summary of Current Research
Professor of Biochemistry & Molecular Biology Dr. Skach received his BS in Biochemistry and Biophysics from Oregon State University in 1979 and his MD Degree from Harvard Medical School in 1983. He completed clinical training in Internal Medicine, Hematology and Oncology at University of California, San Francisco and then undertook postdoctoral studies with Vishwanath Lingappa, also at UCSF. He started his laboratory at the University of Pennsylvania and moved to OHSU in 1998.
"Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex,"
"Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase,"
"Kinetic analysis of ribosome-bound fluorescent proteins reveals an early, stable, cotranslational folding intermediate,"
"Thermal instability of Î”f508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: Protection by single suppressor mutations and inhibiting channel activity,"
"Two-step insertion at the SecY translocon,"