Martin Pike, Ph.D.

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Dr. Pike's current research is focused on studying the pathophysiology of brain diseases (stroke, malignant glioma, alzheimers) using MRI/MRS in tandem with other approaches. His lab employs dynamic contrast MRI approaches to investigate anti-angiogenic/anti-tumor treatment strategies employing mouse models of malignant glioma. His group is also investigating blood brain barrier disruption in stroke and stroke neuroprotection strategies. MR based molecular imaging approaches are also being employed to investigate stroke related inflammation.

Summary of Current Research

Dr. Pike received his undergraduate degree from Williams College in Williamstown, MA in 1978 and his doctoral degree from SUNY in the Department of Chemistry in 1985. He was an NIH Postdoctoral Fellow at The Johns Hopkins University School of Medicine, Division of Cardiology in Baltimore, MD (1985-88), Dr. Pike was a faculty member at the Department of Medicine, Division of Cardiovascular Disease and Department of Cell Biology at the University of Alabama at Birmingham from 1988 to 2008. He joined the AIRC in 2007 as a Visiting Scholar and 2008 as an Associate Scientist and full member of the OHSU Knight Cancer Institute.

Selected Publications

"Cancer nanomedicine," Journal of Nanomaterials (Vol: 2013, ) - 2013

"Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma," Neuro-Oncology (Vol: 15, Issue: 12, Page 1673-1683) - 2013

"Estradiol modulates post-ischemic cerebral vascular remodeling and improves long-term functional outcome in a rat model of stroke," Brain Research (Vol: 1461, Page 76-86) - 2012

"Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination," Journal of Magnetic Resonance (Vol: 206, Issue: 2, Page 190-199) - 2010

"A new model of cortical stroke in the rhesus macaque," Journal of Cerebral Blood Flow and Metabolism (Vol: 29, Issue: 6, Page 1175-1186) - 2009



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503 494-8311