Richard Maurer, Ph.D.
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- Lab Phone:
- 503 494-7624
To adapt to the environment, cells must respond to extracellular events with selective changes in gene expression. Receptor-regulated protein kinases are an important signaling mechanism which permits events at the cell membrane to alter the transcription of specific genes. This laboratory seeks to understand the intracellular signaling pathways which carry the message to the nucleus well as the nuclear events which mediate changes in pituitary hormone gene expression. Some of our studies examine the regulation of luteinizing hormone and follicle stimulating hormone gene expression. These pituitary hormones are essential for normal reproductive function. We also study the regulation of prolactin, a pituitary hormone which is essential for lactation. The studies seek to identify the signal transduction pathways, specific DNA elements and transcription factors which are required for the tissue-specific, regulated expression of these pituitary hormone genes. Several recent studies have focused on the role of LIM homeodomain transcription factors and their co-activators in regulating pituitary hormone promoter activity.
"Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17,"
"Generation of mice with a conditional allele for Ift172,"
"Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys134,"
"Transcription intermediary factor 1Î³ decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1,"
"Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1,"