Bruce Magun, Ph.D
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My major fields of interest involve cellular mechanisms of inflammatory signaling cascades that control the responses to environmental toxic agents.In some studies, the laboratory investigates how proinflammatory signals (cytokines, toxins, and other stressors) interact with surface receptors to activate the stress-activated protein kinases and NF-kappaB and how activation of these pathways leads to transcriptional regulation of genes. Some projects involve the effects of ricin, a potential bioterrorist agent, on activating proinflammatory pathways in vitro and in mouse models.In other studies we are investigating the mechanisms that control the responses keratinocytes to environmental agents such as ultraviolet radiation and xenobiotic toxic agents.
"Production of IL-1Î² by bone marrow-derived macrophages in response to chemotherapeutic drugs: Synergistic effects of doxorubicin and vincristine,"
"Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of Doxorubicin,"
"Ricin and Shiga toxins: Effects on host cell Signal transduction,"
"Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib.,"
"Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome,"